HIV-1 disease progression is associated with bile-salt stimulated lipase (BSSL) gene polymorphism.
<h4>Background</h4>DC-SIGN expressed by dendritic cells captures HIV-1 resulting in trans-infection of CD4(+) T-lymphocytes. However, BSSL (bile-salt stimulated lipase) binding to DC-SIGN interferes with HIV-1 capture. DC-SIGN binding properties of BSSL associate with the polymorphic rep...
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Autores principales: | Martijn J Stax, Neeltje A Kootstra, Angélique B van 't Wout, Michael W T Tanck, Margreet Bakker, Georgios Pollakis, William A Paxton |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Public Library of Science (PLoS)
2012
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Materias: | |
Acceso en línea: | https://doaj.org/article/e420b8d6bfe94ac2bf25aa55f32116cc |
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