HIV-1 disease progression is associated with bile-salt stimulated lipase (BSSL) gene polymorphism.

<h4>Background</h4>DC-SIGN expressed by dendritic cells captures HIV-1 resulting in trans-infection of CD4(+) T-lymphocytes. However, BSSL (bile-salt stimulated lipase) binding to DC-SIGN interferes with HIV-1 capture. DC-SIGN binding properties of BSSL associate with the polymorphic rep...

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Autores principales: Martijn J Stax, Neeltje A Kootstra, Angélique B van 't Wout, Michael W T Tanck, Margreet Bakker, Georgios Pollakis, William A Paxton
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
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Acceso en línea:https://doaj.org/article/e420b8d6bfe94ac2bf25aa55f32116cc
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