Norgestimate inhibits staphylococcal biofilm formation and resensitizes methicillin-resistant Staphylococcus aureus to β-lactam antibiotics

Biofilm formation: Benefits of selective inhibition A synthetic molecule related to the hormone progesterone might keep medical devices free of biofilms without promoting antibiotic resistance. Implanted devices that have become contaminated with biofilms generally must be surgically removed prior t...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yutaka Yoshii, Ken-ichi Okuda, Satomi Yamada, Mari Nagakura, Shinya Sugimoto, Tetsuo Nagano, Takayoshi Okabe, Hirotatsu Kojima, Takeo Iwamoto, Kazuyoshi Kuwano, Yoshimitsu Mizunoe
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Microbial ecology QR100-130
Acceso en línea:	https://doaj.org/article/e42199373d6b4156aca7d9de6a5cd685
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e42199373d6b4156aca7d9de6a5cd685
record_format	dspace
spelling	oai:doaj.org-article:e42199373d6b4156aca7d9de6a5cd6852021-12-02T15:10:33ZNorgestimate inhibits staphylococcal biofilm formation and resensitizes methicillin-resistant Staphylococcus aureus to β-lactam antibiotics10.1038/s41522-017-0026-12055-5008https://doaj.org/article/e42199373d6b4156aca7d9de6a5cd6852017-07-01T00:00:00Zhttps://doi.org/10.1038/s41522-017-0026-1https://doaj.org/toc/2055-5008Biofilm formation: Benefits of selective inhibition A synthetic molecule related to the hormone progesterone might keep medical devices free of biofilms without promoting antibiotic resistance. Implanted devices that have become contaminated with biofilms generally must be surgically removed prior to treating the underlying infection with antibiotics. Ken-ichi Okuda and colleagues at The Jikei University School of Medicine in Tokyo, with co-workers elsewhere in Japan, found that the synthetic progesterone analog norgestimate inhibits biofilm formation without inhibiting bacterial growth. They regard this selective effect on biofilm formation as a significant advantage, as it reduces the risk of inducing resistance in the targeted bacteria. They demonstrated the effect using staphylococcal bacteria, including the problematic and highly dangerous methicillin-resistant Staphylococcus aureus (MRSA). The research also indicated that norgestimate can resensitize MRSA bacteria to some of the antibiotics they are resistant to.Yutaka YoshiiKen-ichi OkudaSatomi YamadaMari NagakuraShinya SugimotoTetsuo NaganoTakayoshi OkabeHirotatsu KojimaTakeo IwamotoKazuyoshi KuwanoYoshimitsu MizunoeNature PortfolioarticleMicrobial ecologyQR100-130ENnpj Biofilms and Microbiomes, Vol 3, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbial ecology QR100-130
spellingShingle	Microbial ecology QR100-130 Yutaka Yoshii Ken-ichi Okuda Satomi Yamada Mari Nagakura Shinya Sugimoto Tetsuo Nagano Takayoshi Okabe Hirotatsu Kojima Takeo Iwamoto Kazuyoshi Kuwano Yoshimitsu Mizunoe Norgestimate inhibits staphylococcal biofilm formation and resensitizes methicillin-resistant Staphylococcus aureus to β-lactam antibiotics
description	Biofilm formation: Benefits of selective inhibition A synthetic molecule related to the hormone progesterone might keep medical devices free of biofilms without promoting antibiotic resistance. Implanted devices that have become contaminated with biofilms generally must be surgically removed prior to treating the underlying infection with antibiotics. Ken-ichi Okuda and colleagues at The Jikei University School of Medicine in Tokyo, with co-workers elsewhere in Japan, found that the synthetic progesterone analog norgestimate inhibits biofilm formation without inhibiting bacterial growth. They regard this selective effect on biofilm formation as a significant advantage, as it reduces the risk of inducing resistance in the targeted bacteria. They demonstrated the effect using staphylococcal bacteria, including the problematic and highly dangerous methicillin-resistant Staphylococcus aureus (MRSA). The research also indicated that norgestimate can resensitize MRSA bacteria to some of the antibiotics they are resistant to.
format	article
author	Yutaka Yoshii Ken-ichi Okuda Satomi Yamada Mari Nagakura Shinya Sugimoto Tetsuo Nagano Takayoshi Okabe Hirotatsu Kojima Takeo Iwamoto Kazuyoshi Kuwano Yoshimitsu Mizunoe
author_facet	Yutaka Yoshii Ken-ichi Okuda Satomi Yamada Mari Nagakura Shinya Sugimoto Tetsuo Nagano Takayoshi Okabe Hirotatsu Kojima Takeo Iwamoto Kazuyoshi Kuwano Yoshimitsu Mizunoe
author_sort	Yutaka Yoshii
title	Norgestimate inhibits staphylococcal biofilm formation and resensitizes methicillin-resistant Staphylococcus aureus to β-lactam antibiotics
title_short	Norgestimate inhibits staphylococcal biofilm formation and resensitizes methicillin-resistant Staphylococcus aureus to β-lactam antibiotics
title_full	Norgestimate inhibits staphylococcal biofilm formation and resensitizes methicillin-resistant Staphylococcus aureus to β-lactam antibiotics
title_fullStr	Norgestimate inhibits staphylococcal biofilm formation and resensitizes methicillin-resistant Staphylococcus aureus to β-lactam antibiotics
title_full_unstemmed	Norgestimate inhibits staphylococcal biofilm formation and resensitizes methicillin-resistant Staphylococcus aureus to β-lactam antibiotics
title_sort	norgestimate inhibits staphylococcal biofilm formation and resensitizes methicillin-resistant staphylococcus aureus to β-lactam antibiotics
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e42199373d6b4156aca7d9de6a5cd685
work_keys_str_mv	AT yutakayoshii norgestimateinhibitsstaphylococcalbiofilmformationandresensitizesmethicillinresistantstaphylococcusaureustoblactamantibiotics AT kenichiokuda norgestimateinhibitsstaphylococcalbiofilmformationandresensitizesmethicillinresistantstaphylococcusaureustoblactamantibiotics AT satomiyamada norgestimateinhibitsstaphylococcalbiofilmformationandresensitizesmethicillinresistantstaphylococcusaureustoblactamantibiotics AT marinagakura norgestimateinhibitsstaphylococcalbiofilmformationandresensitizesmethicillinresistantstaphylococcusaureustoblactamantibiotics AT shinyasugimoto norgestimateinhibitsstaphylococcalbiofilmformationandresensitizesmethicillinresistantstaphylococcusaureustoblactamantibiotics AT tetsuonagano norgestimateinhibitsstaphylococcalbiofilmformationandresensitizesmethicillinresistantstaphylococcusaureustoblactamantibiotics AT takayoshiokabe norgestimateinhibitsstaphylococcalbiofilmformationandresensitizesmethicillinresistantstaphylococcusaureustoblactamantibiotics AT hirotatsukojima norgestimateinhibitsstaphylococcalbiofilmformationandresensitizesmethicillinresistantstaphylococcusaureustoblactamantibiotics AT takeoiwamoto norgestimateinhibitsstaphylococcalbiofilmformationandresensitizesmethicillinresistantstaphylococcusaureustoblactamantibiotics AT kazuyoshikuwano norgestimateinhibitsstaphylococcalbiofilmformationandresensitizesmethicillinresistantstaphylococcusaureustoblactamantibiotics AT yoshimitsumizunoe norgestimateinhibitsstaphylococcalbiofilmformationandresensitizesmethicillinresistantstaphylococcusaureustoblactamantibiotics
_version_	1718387725543931904

Norgestimate inhibits staphylococcal biofilm formation and resensitizes methicillin-resistant Staphylococcus aureus to β-lactam antibiotics

Ejemplares similares