Leptin expression is substantially correlated with prognosis of urinary bladder carcinoma

This study examined leptin expression in cases of bladder cancer and its diagnostic and prognostic usefulness in bladder malignancies. A set of 128 urinary bladder cancer cases and 24 normal specimens of bladders were employed for an immunohistochemical investigation of leptin expression in tissue m...

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Autores principales:	Mohamad Nidal Khabaz, Imtiaz Ahmad Qureshi, Jaudah Ahmad Al-Maghrabi
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	leptin urinary bladder cancer immunohistochemistry Medicine R
Acceso en línea:	https://doaj.org/article/e421b30cac084b74989a94db5e1da8b7
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spelling	oai:doaj.org-article:e421b30cac084b74989a94db5e1da8b72021-11-26T11:19:48ZLeptin expression is substantially correlated with prognosis of urinary bladder carcinoma1993-28201819-635710.1080/19932820.2021.1949798https://doaj.org/article/e421b30cac084b74989a94db5e1da8b72021-01-01T00:00:00Zhttp://dx.doi.org/10.1080/19932820.2021.1949798https://doaj.org/toc/1993-2820https://doaj.org/toc/1819-6357This study examined leptin expression in cases of bladder cancer and its diagnostic and prognostic usefulness in bladder malignancies. A set of 128 urinary bladder cancer cases and 24 normal specimens of bladders were employed for an immunohistochemical investigation of leptin expression in tissue microarrays. Leptin was up-regulated during transformation and was identified as brown cytoplasmic granules in the malignant urothelium of 123 (96%) bladder neoplasms, of which 68 (53.1%) cases showed high levels (moderate to strong) of staining. Strong staining was found to be associated with high stages (P = 0.001), muscularis propria infiltration (P < 0.001), vascular invasion (P < 0.03), lymph node involvement (P < 0.02), metastases (P < 0.05), and mortality (P < 0.03). Furthermore, various important survival distributions were detected with leptin expression in the malignant urothelium (P < 0.03). These pilot results suggest that leptin might be a valid marker for predicting the stage and bad prognoses in bladder carcinoma.Mohamad Nidal KhabazImtiaz Ahmad QureshiJaudah Ahmad Al-MaghrabiTaylor & Francis Grouparticleleptinurinary bladder cancerimmunohistochemistryMedicineRENLibyan Journal of Medicine, Vol 16, Iss 1 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	leptin urinary bladder cancer immunohistochemistry Medicine R
spellingShingle	leptin urinary bladder cancer immunohistochemistry Medicine R Mohamad Nidal Khabaz Imtiaz Ahmad Qureshi Jaudah Ahmad Al-Maghrabi Leptin expression is substantially correlated with prognosis of urinary bladder carcinoma
description	This study examined leptin expression in cases of bladder cancer and its diagnostic and prognostic usefulness in bladder malignancies. A set of 128 urinary bladder cancer cases and 24 normal specimens of bladders were employed for an immunohistochemical investigation of leptin expression in tissue microarrays. Leptin was up-regulated during transformation and was identified as brown cytoplasmic granules in the malignant urothelium of 123 (96%) bladder neoplasms, of which 68 (53.1%) cases showed high levels (moderate to strong) of staining. Strong staining was found to be associated with high stages (P = 0.001), muscularis propria infiltration (P < 0.001), vascular invasion (P < 0.03), lymph node involvement (P < 0.02), metastases (P < 0.05), and mortality (P < 0.03). Furthermore, various important survival distributions were detected with leptin expression in the malignant urothelium (P < 0.03). These pilot results suggest that leptin might be a valid marker for predicting the stage and bad prognoses in bladder carcinoma.
format	article
author	Mohamad Nidal Khabaz Imtiaz Ahmad Qureshi Jaudah Ahmad Al-Maghrabi
author_facet	Mohamad Nidal Khabaz Imtiaz Ahmad Qureshi Jaudah Ahmad Al-Maghrabi
author_sort	Mohamad Nidal Khabaz
title	Leptin expression is substantially correlated with prognosis of urinary bladder carcinoma
title_short	Leptin expression is substantially correlated with prognosis of urinary bladder carcinoma
title_full	Leptin expression is substantially correlated with prognosis of urinary bladder carcinoma
title_fullStr	Leptin expression is substantially correlated with prognosis of urinary bladder carcinoma
title_full_unstemmed	Leptin expression is substantially correlated with prognosis of urinary bladder carcinoma
title_sort	leptin expression is substantially correlated with prognosis of urinary bladder carcinoma
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/e421b30cac084b74989a94db5e1da8b7
work_keys_str_mv	AT mohamadnidalkhabaz leptinexpressionissubstantiallycorrelatedwithprognosisofurinarybladdercarcinoma AT imtiazahmadqureshi leptinexpressionissubstantiallycorrelatedwithprognosisofurinarybladdercarcinoma AT jaudahahmadalmaghrabi leptinexpressionissubstantiallycorrelatedwithprognosisofurinarybladdercarcinoma
_version_	1718409504110936064

Leptin expression is substantially correlated with prognosis of urinary bladder carcinoma

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