Kanglaite sensitizes colorectal cancer cells to Taxol via NF-κΒ inhibition and connexin 43 upregulation

Abstract Taxol, a first-line anti-tumour drug, has low effectiveness against colorectal cancer. Combination with other agents is an effective strategy to enhance Taxol cytotoxicity. Kanglaite injection is an extract from Coix lacryma-jobi seed and is usually combined with other agents to treat cance...

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Autores principales:	Yijia Wang, Chunze Zhang, Shiwu Zhang, Zhenying Zhao, Jiawen Wang, Jiali Song, Yue Wang, Jun Liu, Shaobin Hou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e4228a4b2cbd474da6ffe723bba5ab65
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spelling	oai:doaj.org-article:e4228a4b2cbd474da6ffe723bba5ab652021-12-02T16:07:45ZKanglaite sensitizes colorectal cancer cells to Taxol via NF-κΒ inhibition and connexin 43 upregulation10.1038/s41598-017-01480-22045-2322https://doaj.org/article/e4228a4b2cbd474da6ffe723bba5ab652017-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01480-2https://doaj.org/toc/2045-2322Abstract Taxol, a first-line anti-tumour drug, has low effectiveness against colorectal cancer. Combination with other agents is an effective strategy to enhance Taxol cytotoxicity. Kanglaite injection is an extract from Coix lacryma-jobi seed and is usually combined with other agents to treat cancer. The aim of this study was to investigate the treatment effect of Taxol combined with Kanglaite on colorectal cancer cell lines. Kanglaite pretreatment followed by Taxol treatment was found to show the best synergism among all combination strategies. This combination also resulted in the smallest tumour volume in a Balb/c mice model. Kanglaite inhibited the expression of nuclear factor (NF)-κΒ and upregulated that of connexin 43, both of which sensitized cancer cells to Taxol. Moreover, Kanglaite increased many cellular variations caused by Taxol, including tubulin polymerization, caspase-3 cleavage, and upregulated expression of survivin and cyclin B1. These results suggest that Kanglaite pretreatment may increase the effect of Taxol on colorectal cancer.Yijia WangChunze ZhangShiwu ZhangZhenying ZhaoJiawen WangJiali SongYue WangJun LiuShaobin HouNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yijia Wang Chunze Zhang Shiwu Zhang Zhenying Zhao Jiawen Wang Jiali Song Yue Wang Jun Liu Shaobin Hou Kanglaite sensitizes colorectal cancer cells to Taxol via NF-κΒ inhibition and connexin 43 upregulation
description	Abstract Taxol, a first-line anti-tumour drug, has low effectiveness against colorectal cancer. Combination with other agents is an effective strategy to enhance Taxol cytotoxicity. Kanglaite injection is an extract from Coix lacryma-jobi seed and is usually combined with other agents to treat cancer. The aim of this study was to investigate the treatment effect of Taxol combined with Kanglaite on colorectal cancer cell lines. Kanglaite pretreatment followed by Taxol treatment was found to show the best synergism among all combination strategies. This combination also resulted in the smallest tumour volume in a Balb/c mice model. Kanglaite inhibited the expression of nuclear factor (NF)-κΒ and upregulated that of connexin 43, both of which sensitized cancer cells to Taxol. Moreover, Kanglaite increased many cellular variations caused by Taxol, including tubulin polymerization, caspase-3 cleavage, and upregulated expression of survivin and cyclin B1. These results suggest that Kanglaite pretreatment may increase the effect of Taxol on colorectal cancer.
format	article
author	Yijia Wang Chunze Zhang Shiwu Zhang Zhenying Zhao Jiawen Wang Jiali Song Yue Wang Jun Liu Shaobin Hou
author_facet	Yijia Wang Chunze Zhang Shiwu Zhang Zhenying Zhao Jiawen Wang Jiali Song Yue Wang Jun Liu Shaobin Hou
author_sort	Yijia Wang
title	Kanglaite sensitizes colorectal cancer cells to Taxol via NF-κΒ inhibition and connexin 43 upregulation
title_short	Kanglaite sensitizes colorectal cancer cells to Taxol via NF-κΒ inhibition and connexin 43 upregulation
title_full	Kanglaite sensitizes colorectal cancer cells to Taxol via NF-κΒ inhibition and connexin 43 upregulation
title_fullStr	Kanglaite sensitizes colorectal cancer cells to Taxol via NF-κΒ inhibition and connexin 43 upregulation
title_full_unstemmed	Kanglaite sensitizes colorectal cancer cells to Taxol via NF-κΒ inhibition and connexin 43 upregulation
title_sort	kanglaite sensitizes colorectal cancer cells to taxol via nf-κβ inhibition and connexin 43 upregulation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e4228a4b2cbd474da6ffe723bba5ab65
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_version_	1718384751326265344

Kanglaite sensitizes colorectal cancer cells to Taxol via NF-κΒ inhibition and connexin 43 upregulation

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