Update On Cenegermin Eye Drops In The Treatment Of Neurotrophic Keratitis

Hosam Sheha,1–3 Sean Tighe,2 Omar Hashem,3 Yasutaka Hayashida4 1Department of Ophthalmology, Manhattan Eye, Ear & Throat Hospital, Northwell Health, New York, NY, USA; 2Department of Ophthalmology, Florida International University Herbert Wertheim College of Medicine, Miami, FL, US...

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Autores principales:	Sheha H, Tighe S, Hashem O, Hayashida Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Cenegermin Corneal nerves Neurotrophic keratitis Nerve growth factors Persistent epithelial defect. Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/e42452cb1e32412c85c8660eaff963e9
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spelling	oai:doaj.org-article:e42452cb1e32412c85c8660eaff963e92021-12-02T08:02:27ZUpdate On Cenegermin Eye Drops In The Treatment Of Neurotrophic Keratitis1177-5483https://doaj.org/article/e42452cb1e32412c85c8660eaff963e92019-10-01T00:00:00Zhttps://www.dovepress.com/update-on-cenegermin-eye-drops-in-the-treatment-of-neurotrophic-kerati-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Hosam Sheha,1–3 Sean Tighe,2 Omar Hashem,3 Yasutaka Hayashida4 1Department of Ophthalmology, Manhattan Eye, Ear & Throat Hospital, Northwell Health, New York, NY, USA; 2Department of Ophthalmology, Florida International University Herbert Wertheim College of Medicine, Miami, FL, USA; 3Department of Ophthalmology, Research Institute of Ophthalmology, Cairo, Egypt; 4Department of Ophthalmology, Osaka University Graduate School of Medicine, Suita, JapanCorrespondence: Hosam ShehaDepartment of Ophthalmology, Manhattan Eye, Ear & Throat Hospital, 210 E 64th Street, New York, NY 10065, USATel +1 305-710-4709Email hoss88@gmail.comAbstract: Neurotrophic keratitis is an underdiagnosed degenerative condition induced by impairment to the corneal nerves which may lead to persistent epithelial defects and corneal blindness. Current medical and surgical treatments are only supportive and poorly tackle the underlying problem of corneal anesthesia; hence, fail to provide a permanent cure. Cenegermin is a newly introduced recombinant human nerve growth factor (rhNGF) that may address this issue. Preliminary clinical trials have demonstrated the safety and efficacy of topical cenegermin in patients with moderate to severe neurotrophic keratitis; however, the clinical experience with this drug is still limited. This review summarizes the pathogenesis and management of neurotrophic keratitis as well as the mechanism of action, uses, and limitations of cenegermin eye drops in the treatment of neurotrophic keratitis.Keywords: cenegermin, corneal nerves, neurotrophic keratitis, nerve growth factors, persistent epithelial defectSheha HTighe SHashem OHayashida YDove Medical PressarticleCenegerminCorneal nervesNeurotrophic keratitisNerve growth factorsPersistent epithelial defect.OphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 13, Pp 1973-1980 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cenegermin Corneal nerves Neurotrophic keratitis Nerve growth factors Persistent epithelial defect. Ophthalmology RE1-994
spellingShingle	Cenegermin Corneal nerves Neurotrophic keratitis Nerve growth factors Persistent epithelial defect. Ophthalmology RE1-994 Sheha H Tighe S Hashem O Hayashida Y Update On Cenegermin Eye Drops In The Treatment Of Neurotrophic Keratitis
description	Hosam Sheha,1–3 Sean Tighe,2 Omar Hashem,3 Yasutaka Hayashida4 1Department of Ophthalmology, Manhattan Eye, Ear & Throat Hospital, Northwell Health, New York, NY, USA; 2Department of Ophthalmology, Florida International University Herbert Wertheim College of Medicine, Miami, FL, USA; 3Department of Ophthalmology, Research Institute of Ophthalmology, Cairo, Egypt; 4Department of Ophthalmology, Osaka University Graduate School of Medicine, Suita, JapanCorrespondence: Hosam ShehaDepartment of Ophthalmology, Manhattan Eye, Ear & Throat Hospital, 210 E 64th Street, New York, NY 10065, USATel +1 305-710-4709Email hoss88@gmail.comAbstract: Neurotrophic keratitis is an underdiagnosed degenerative condition induced by impairment to the corneal nerves which may lead to persistent epithelial defects and corneal blindness. Current medical and surgical treatments are only supportive and poorly tackle the underlying problem of corneal anesthesia; hence, fail to provide a permanent cure. Cenegermin is a newly introduced recombinant human nerve growth factor (rhNGF) that may address this issue. Preliminary clinical trials have demonstrated the safety and efficacy of topical cenegermin in patients with moderate to severe neurotrophic keratitis; however, the clinical experience with this drug is still limited. This review summarizes the pathogenesis and management of neurotrophic keratitis as well as the mechanism of action, uses, and limitations of cenegermin eye drops in the treatment of neurotrophic keratitis.Keywords: cenegermin, corneal nerves, neurotrophic keratitis, nerve growth factors, persistent epithelial defect
format	article
author	Sheha H Tighe S Hashem O Hayashida Y
author_facet	Sheha H Tighe S Hashem O Hayashida Y
author_sort	Sheha H
title	Update On Cenegermin Eye Drops In The Treatment Of Neurotrophic Keratitis
title_short	Update On Cenegermin Eye Drops In The Treatment Of Neurotrophic Keratitis
title_full	Update On Cenegermin Eye Drops In The Treatment Of Neurotrophic Keratitis
title_fullStr	Update On Cenegermin Eye Drops In The Treatment Of Neurotrophic Keratitis
title_full_unstemmed	Update On Cenegermin Eye Drops In The Treatment Of Neurotrophic Keratitis
title_sort	update on cenegermin eye drops in the treatment of neurotrophic keratitis
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/e42452cb1e32412c85c8660eaff963e9
work_keys_str_mv	AT shehah updateoncenegermineyedropsinthetreatmentofneurotrophickeratitis AT tighes updateoncenegermineyedropsinthetreatmentofneurotrophickeratitis AT hashemo updateoncenegermineyedropsinthetreatmentofneurotrophickeratitis AT hayashiday updateoncenegermineyedropsinthetreatmentofneurotrophickeratitis
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Update On Cenegermin Eye Drops In The Treatment Of Neurotrophic Keratitis

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