Genomic profiling reveals heterogeneous populations of ductal carcinoma in situ of the breast

Satoi Nagasawa and Yuta Kuze et al. report a multi-omic analysis of ductal carcinoma in situ (DCIS) of the breast, including whole-exome, single-cell, and spatial transcriptome sequencing. They find that for patients under 45 years of age, HER2 amplification and GATA3 mutation are associated with hi...

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Autores principales:	Satoi Nagasawa, Yuta Kuze, Ichiro Maeda, Yasuyuki Kojima, Ai Motoyoshi, Tatsuya Onishi, Tsuguo Iwatani, Takamichi Yokoe, Junki Koike, Motohiro Chosokabe, Manabu Kubota, Hibiki Seino, Ayako Suzuki, Masahide Seki, Katsuya Tsuchihara, Eisuke Inoue, Koichiro Tsugawa, Tomohiko Ohta, Yutaka Suzuki
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/e426aed0800f44f79e31480b616c2d54
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spelling	oai:doaj.org-article:e426aed0800f44f79e31480b616c2d542021-12-02T14:23:13ZGenomic profiling reveals heterogeneous populations of ductal carcinoma in situ of the breast10.1038/s42003-021-01959-92399-3642https://doaj.org/article/e426aed0800f44f79e31480b616c2d542021-04-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01959-9https://doaj.org/toc/2399-3642Satoi Nagasawa and Yuta Kuze et al. report a multi-omic analysis of ductal carcinoma in situ (DCIS) of the breast, including whole-exome, single-cell, and spatial transcriptome sequencing. They find that for patients under 45 years of age, HER2 amplification and GATA3 mutation are associated with higher risk of relapse, suggesting they could be used as predictive markers when deciding on a treatment course.Satoi NagasawaYuta KuzeIchiro MaedaYasuyuki KojimaAi MotoyoshiTatsuya OnishiTsuguo IwataniTakamichi YokoeJunki KoikeMotohiro ChosokabeManabu KubotaHibiki SeinoAyako SuzukiMasahide SekiKatsuya TsuchiharaEisuke InoueKoichiro TsugawaTomohiko OhtaYutaka SuzukiNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Satoi Nagasawa Yuta Kuze Ichiro Maeda Yasuyuki Kojima Ai Motoyoshi Tatsuya Onishi Tsuguo Iwatani Takamichi Yokoe Junki Koike Motohiro Chosokabe Manabu Kubota Hibiki Seino Ayako Suzuki Masahide Seki Katsuya Tsuchihara Eisuke Inoue Koichiro Tsugawa Tomohiko Ohta Yutaka Suzuki Genomic profiling reveals heterogeneous populations of ductal carcinoma in situ of the breast
description	Satoi Nagasawa and Yuta Kuze et al. report a multi-omic analysis of ductal carcinoma in situ (DCIS) of the breast, including whole-exome, single-cell, and spatial transcriptome sequencing. They find that for patients under 45 years of age, HER2 amplification and GATA3 mutation are associated with higher risk of relapse, suggesting they could be used as predictive markers when deciding on a treatment course.
format	article
author	Satoi Nagasawa Yuta Kuze Ichiro Maeda Yasuyuki Kojima Ai Motoyoshi Tatsuya Onishi Tsuguo Iwatani Takamichi Yokoe Junki Koike Motohiro Chosokabe Manabu Kubota Hibiki Seino Ayako Suzuki Masahide Seki Katsuya Tsuchihara Eisuke Inoue Koichiro Tsugawa Tomohiko Ohta Yutaka Suzuki
author_facet	Satoi Nagasawa Yuta Kuze Ichiro Maeda Yasuyuki Kojima Ai Motoyoshi Tatsuya Onishi Tsuguo Iwatani Takamichi Yokoe Junki Koike Motohiro Chosokabe Manabu Kubota Hibiki Seino Ayako Suzuki Masahide Seki Katsuya Tsuchihara Eisuke Inoue Koichiro Tsugawa Tomohiko Ohta Yutaka Suzuki
author_sort	Satoi Nagasawa
title	Genomic profiling reveals heterogeneous populations of ductal carcinoma in situ of the breast
title_short	Genomic profiling reveals heterogeneous populations of ductal carcinoma in situ of the breast
title_full	Genomic profiling reveals heterogeneous populations of ductal carcinoma in situ of the breast
title_fullStr	Genomic profiling reveals heterogeneous populations of ductal carcinoma in situ of the breast
title_full_unstemmed	Genomic profiling reveals heterogeneous populations of ductal carcinoma in situ of the breast
title_sort	genomic profiling reveals heterogeneous populations of ductal carcinoma in situ of the breast
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e426aed0800f44f79e31480b616c2d54
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Genomic profiling reveals heterogeneous populations of ductal carcinoma in situ of the breast

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