Single cell transcriptomics identifies stem cell-derived graft composition in a model of Parkinson’s disease

What happens to cells on engrafting into the brain in animal models to treat Parkinson’s disease is unclear. Here, the authors use scRNA-seq to examine ventral midbrain (VM)-patterned human embryonic stem cells after functional maturation in a pre-clinical rat model for Parkinson’s disease and ident...

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Autores principales:	Katarína Tiklová, Sara Nolbrant, Alessandro Fiorenzano, Åsa K. Björklund, Yogita Sharma, Andreas Heuer, Linda Gillberg, Deirdre B. Hoban, Tiago Cardoso, Andrew F. Adler, Marcella Birtele, Hilda Lundén-Miguel, Nikolaos Volakakis, Agnete Kirkeby, Thomas Perlmann, Malin Parmar
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e42834ed181548b18cc8c7636ddae20d
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spelling	oai:doaj.org-article:e42834ed181548b18cc8c7636ddae20d2021-12-02T15:43:16ZSingle cell transcriptomics identifies stem cell-derived graft composition in a model of Parkinson’s disease10.1038/s41467-020-16225-52041-1723https://doaj.org/article/e42834ed181548b18cc8c7636ddae20d2020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16225-5https://doaj.org/toc/2041-1723What happens to cells on engrafting into the brain in animal models to treat Parkinson’s disease is unclear. Here, the authors use scRNA-seq to examine ventral midbrain (VM)-patterned human embryonic stem cells after functional maturation in a pre-clinical rat model for Parkinson’s disease and identify perivascular-like cells.Katarína TiklováSara NolbrantAlessandro FiorenzanoÅsa K. BjörklundYogita SharmaAndreas HeuerLinda GillbergDeirdre B. HobanTiago CardosoAndrew F. AdlerMarcella BirteleHilda Lundén-MiguelNikolaos VolakakisAgnete KirkebyThomas PerlmannMalin ParmarNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Katarína Tiklová Sara Nolbrant Alessandro Fiorenzano Åsa K. Björklund Yogita Sharma Andreas Heuer Linda Gillberg Deirdre B. Hoban Tiago Cardoso Andrew F. Adler Marcella Birtele Hilda Lundén-Miguel Nikolaos Volakakis Agnete Kirkeby Thomas Perlmann Malin Parmar Single cell transcriptomics identifies stem cell-derived graft composition in a model of Parkinson’s disease
description	What happens to cells on engrafting into the brain in animal models to treat Parkinson’s disease is unclear. Here, the authors use scRNA-seq to examine ventral midbrain (VM)-patterned human embryonic stem cells after functional maturation in a pre-clinical rat model for Parkinson’s disease and identify perivascular-like cells.
format	article
author	Katarína Tiklová Sara Nolbrant Alessandro Fiorenzano Åsa K. Björklund Yogita Sharma Andreas Heuer Linda Gillberg Deirdre B. Hoban Tiago Cardoso Andrew F. Adler Marcella Birtele Hilda Lundén-Miguel Nikolaos Volakakis Agnete Kirkeby Thomas Perlmann Malin Parmar
author_facet	Katarína Tiklová Sara Nolbrant Alessandro Fiorenzano Åsa K. Björklund Yogita Sharma Andreas Heuer Linda Gillberg Deirdre B. Hoban Tiago Cardoso Andrew F. Adler Marcella Birtele Hilda Lundén-Miguel Nikolaos Volakakis Agnete Kirkeby Thomas Perlmann Malin Parmar
author_sort	Katarína Tiklová
title	Single cell transcriptomics identifies stem cell-derived graft composition in a model of Parkinson’s disease
title_short	Single cell transcriptomics identifies stem cell-derived graft composition in a model of Parkinson’s disease
title_full	Single cell transcriptomics identifies stem cell-derived graft composition in a model of Parkinson’s disease
title_fullStr	Single cell transcriptomics identifies stem cell-derived graft composition in a model of Parkinson’s disease
title_full_unstemmed	Single cell transcriptomics identifies stem cell-derived graft composition in a model of Parkinson’s disease
title_sort	single cell transcriptomics identifies stem cell-derived graft composition in a model of parkinson’s disease
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e42834ed181548b18cc8c7636ddae20d
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Single cell transcriptomics identifies stem cell-derived graft composition in a model of Parkinson’s disease

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