The promise of microRNA-based therapies in Alzheimer’s disease: challenges and perspectives

Abstract Multi-pathway approaches for the treatment of complex polygenic disorders are emerging as alternatives to classical monotarget therapies and microRNAs are of particular interest in that regard. MicroRNA research has come a long way from their initial discovery to the cumulative appreciation...

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Autores principales:	Hannah Walgrave, Lujia Zhou, Bart De Strooper, Evgenia Salta
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	microRNA Alzheimer’s disease therapeutics neurodegenerative diseases Neurology. Diseases of the nervous system RC346-429 Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/e43a11d9d7444dbc9f5e8a4b95efafba
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spelling	oai:doaj.org-article:e43a11d9d7444dbc9f5e8a4b95efafba2021-11-08T10:45:22ZThe promise of microRNA-based therapies in Alzheimer’s disease: challenges and perspectives10.1186/s13024-021-00496-71750-1326https://doaj.org/article/e43a11d9d7444dbc9f5e8a4b95efafba2021-11-01T00:00:00Zhttps://doi.org/10.1186/s13024-021-00496-7https://doaj.org/toc/1750-1326Abstract Multi-pathway approaches for the treatment of complex polygenic disorders are emerging as alternatives to classical monotarget therapies and microRNAs are of particular interest in that regard. MicroRNA research has come a long way from their initial discovery to the cumulative appreciation of their regulatory potential in healthy and diseased brain. However, systematic interrogation of putative therapeutic or toxic effects of microRNAs in (models of) Alzheimer’s disease is currently missing and fundamental research findings are yet to be translated into clinical applications. Here, we review the literature to summarize the knowledge on microRNA regulation in Alzheimer’s pathophysiology and to critically discuss whether and to what extent these increasing insights can be exploited for the development of microRNA-based therapeutics in the clinic.Hannah WalgraveLujia ZhouBart De StrooperEvgenia SaltaBMCarticlemicroRNAAlzheimer’s diseasetherapeuticsneurodegenerative diseasesNeurology. Diseases of the nervous systemRC346-429GeriatricsRC952-954.6ENMolecular Neurodegeneration, Vol 16, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	microRNA Alzheimer’s disease therapeutics neurodegenerative diseases Neurology. Diseases of the nervous system RC346-429 Geriatrics RC952-954.6
spellingShingle	microRNA Alzheimer’s disease therapeutics neurodegenerative diseases Neurology. Diseases of the nervous system RC346-429 Geriatrics RC952-954.6 Hannah Walgrave Lujia Zhou Bart De Strooper Evgenia Salta The promise of microRNA-based therapies in Alzheimer’s disease: challenges and perspectives
description	Abstract Multi-pathway approaches for the treatment of complex polygenic disorders are emerging as alternatives to classical monotarget therapies and microRNAs are of particular interest in that regard. MicroRNA research has come a long way from their initial discovery to the cumulative appreciation of their regulatory potential in healthy and diseased brain. However, systematic interrogation of putative therapeutic or toxic effects of microRNAs in (models of) Alzheimer’s disease is currently missing and fundamental research findings are yet to be translated into clinical applications. Here, we review the literature to summarize the knowledge on microRNA regulation in Alzheimer’s pathophysiology and to critically discuss whether and to what extent these increasing insights can be exploited for the development of microRNA-based therapeutics in the clinic.
format	article
author	Hannah Walgrave Lujia Zhou Bart De Strooper Evgenia Salta
author_facet	Hannah Walgrave Lujia Zhou Bart De Strooper Evgenia Salta
author_sort	Hannah Walgrave
title	The promise of microRNA-based therapies in Alzheimer’s disease: challenges and perspectives
title_short	The promise of microRNA-based therapies in Alzheimer’s disease: challenges and perspectives
title_full	The promise of microRNA-based therapies in Alzheimer’s disease: challenges and perspectives
title_fullStr	The promise of microRNA-based therapies in Alzheimer’s disease: challenges and perspectives
title_full_unstemmed	The promise of microRNA-based therapies in Alzheimer’s disease: challenges and perspectives
title_sort	promise of microrna-based therapies in alzheimer’s disease: challenges and perspectives
publisher	BMC
publishDate	2021
url	https://doaj.org/article/e43a11d9d7444dbc9f5e8a4b95efafba
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The promise of microRNA-based therapies in Alzheimer’s disease: challenges and perspectives

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