In vivo proximity proteomics of nascent synapses reveals a novel regulator of cytoskeleton-mediated synaptic maturation

The internal molecular mechanisms that underlie excitatory synaptogenesis remain poorly characterized. This study utilizes a chemogenetic approach, in vivo biotin identification (iBioID), to discover previously uncharacterized proteins at nascent synapses. CARMIL3 is identified as a cytoskeletal pro...

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Autores principales:	Erin F. Spence, Shataakshi Dube, Akiyoshi Uezu, Margaret Locke, Erik J. Soderblom, Scott H. Soderling
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e43c74abbac949eab8b79559b2c2b33a
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spelling	oai:doaj.org-article:e43c74abbac949eab8b79559b2c2b33a2021-12-02T15:35:47ZIn vivo proximity proteomics of nascent synapses reveals a novel regulator of cytoskeleton-mediated synaptic maturation10.1038/s41467-019-08288-w2041-1723https://doaj.org/article/e43c74abbac949eab8b79559b2c2b33a2019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08288-whttps://doaj.org/toc/2041-1723The internal molecular mechanisms that underlie excitatory synaptogenesis remain poorly characterized. This study utilizes a chemogenetic approach, in vivo biotin identification (iBioID), to discover previously uncharacterized proteins at nascent synapses. CARMIL3 is identified as a cytoskeletal protein that facilitates spine maturation and AMPAR recruitment.Erin F. SpenceShataakshi DubeAkiyoshi UezuMargaret LockeErik J. SoderblomScott H. SoderlingNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Erin F. Spence Shataakshi Dube Akiyoshi Uezu Margaret Locke Erik J. Soderblom Scott H. Soderling In vivo proximity proteomics of nascent synapses reveals a novel regulator of cytoskeleton-mediated synaptic maturation
description	The internal molecular mechanisms that underlie excitatory synaptogenesis remain poorly characterized. This study utilizes a chemogenetic approach, in vivo biotin identification (iBioID), to discover previously uncharacterized proteins at nascent synapses. CARMIL3 is identified as a cytoskeletal protein that facilitates spine maturation and AMPAR recruitment.
format	article
author	Erin F. Spence Shataakshi Dube Akiyoshi Uezu Margaret Locke Erik J. Soderblom Scott H. Soderling
author_facet	Erin F. Spence Shataakshi Dube Akiyoshi Uezu Margaret Locke Erik J. Soderblom Scott H. Soderling
author_sort	Erin F. Spence
title	In vivo proximity proteomics of nascent synapses reveals a novel regulator of cytoskeleton-mediated synaptic maturation
title_short	In vivo proximity proteomics of nascent synapses reveals a novel regulator of cytoskeleton-mediated synaptic maturation
title_full	In vivo proximity proteomics of nascent synapses reveals a novel regulator of cytoskeleton-mediated synaptic maturation
title_fullStr	In vivo proximity proteomics of nascent synapses reveals a novel regulator of cytoskeleton-mediated synaptic maturation
title_full_unstemmed	In vivo proximity proteomics of nascent synapses reveals a novel regulator of cytoskeleton-mediated synaptic maturation
title_sort	in vivo proximity proteomics of nascent synapses reveals a novel regulator of cytoskeleton-mediated synaptic maturation
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/e43c74abbac949eab8b79559b2c2b33a
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In vivo proximity proteomics of nascent synapses reveals a novel regulator of cytoskeleton-mediated synaptic maturation

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