In vivo proximity proteomics of nascent synapses reveals a novel regulator of cytoskeleton-mediated synaptic maturation
The internal molecular mechanisms that underlie excitatory synaptogenesis remain poorly characterized. This study utilizes a chemogenetic approach, in vivo biotin identification (iBioID), to discover previously uncharacterized proteins at nascent synapses. CARMIL3 is identified as a cytoskeletal pro...
Enregistré dans:
Auteurs principaux: | Erin F. Spence, Shataakshi Dube, Akiyoshi Uezu, Margaret Locke, Erik J. Soderblom, Scott H. Soderling |
---|---|
Format: | article |
Langue: | EN |
Publié: |
Nature Portfolio
2019
|
Sujets: | |
Accès en ligne: | https://doaj.org/article/e43c74abbac949eab8b79559b2c2b33a |
Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|
Documents similaires
-
Evolution of complexity in the zebrafish synapse proteome
par: Àlex Bayés, et autres
Publié: (2017) -
A genetically encoded probe for imaging nascent and mature HA-tagged proteins in vivo
par: Ning Zhao, et autres
Publié: (2019) -
Photoactivatable CaMKII induces synaptic plasticity in single synapses
par: Akihiro C. E. Shibata, et autres
Publié: (2021) -
A new strategy to uncover fragile X proteomic biomarkers using the nascent proteome of peripheral blood mononuclear cells (PBMCs)
par: Olivier Dionne, et autres
Publié: (2021) -
Synuclein Regulates Synaptic Vesicle Clustering and Docking at a Vertebrate Synapse
par: Kaitlyn E. Fouke, et autres
Publié: (2021)