<italic toggle="yes">Lactobacillus</italic> Mucosal Vaccine Vectors: Immune Responses against Bacterial and Viral Antigens

ABSTRACT Lactic acid bacteria (LAB) have been utilized since the 1990s for therapeutic heterologous gene expression. The ability of LAB to elicit an immune response against expressed foreign antigens has led to their exploration as potential mucosal vaccine candidates. LAB vaccine vectors offer many...

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Autores principales:	Jonathan S. LeCureux, Gregg A. Dean
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2018
Materias:	Lactobacillus mucosal immunity mucosal vaccines Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/e43fffd460714771b64807f0e017b13e
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spelling	oai:doaj.org-article:e43fffd460714771b64807f0e017b13e2021-11-15T15:24:23Z<italic toggle="yes">Lactobacillus</italic> Mucosal Vaccine Vectors: Immune Responses against Bacterial and Viral Antigens10.1128/mSphere.00061-182379-5042https://doaj.org/article/e43fffd460714771b64807f0e017b13e2018-06-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSphere.00061-18https://doaj.org/toc/2379-5042ABSTRACT Lactic acid bacteria (LAB) have been utilized since the 1990s for therapeutic heterologous gene expression. The ability of LAB to elicit an immune response against expressed foreign antigens has led to their exploration as potential mucosal vaccine candidates. LAB vaccine vectors offer many attractive advantages: simple, noninvasive administration (usually oral or intranasal), the acceptance and stability of genetic modifications, relatively low cost, and the highest level of safety possible. Experimentation using LAB of the genus Lactobacillus has become popular in recent years due to their ability to elicit strong systemic and mucosal immune responses. This article reviews Lactobacillus vaccine constructs, including Lactobacillus species, antigen expression, model organisms, and in vivo immune responses, with a primary focus on viral and bacterial antigens.Jonathan S. LeCureuxGregg A. DeanAmerican Society for MicrobiologyarticleLactobacillusmucosal immunitymucosal vaccinesMicrobiologyQR1-502ENmSphere, Vol 3, Iss 3 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Lactobacillus mucosal immunity mucosal vaccines Microbiology QR1-502
spellingShingle	Lactobacillus mucosal immunity mucosal vaccines Microbiology QR1-502 Jonathan S. LeCureux Gregg A. Dean <italic toggle="yes">Lactobacillus</italic> Mucosal Vaccine Vectors: Immune Responses against Bacterial and Viral Antigens
description	ABSTRACT Lactic acid bacteria (LAB) have been utilized since the 1990s for therapeutic heterologous gene expression. The ability of LAB to elicit an immune response against expressed foreign antigens has led to their exploration as potential mucosal vaccine candidates. LAB vaccine vectors offer many attractive advantages: simple, noninvasive administration (usually oral or intranasal), the acceptance and stability of genetic modifications, relatively low cost, and the highest level of safety possible. Experimentation using LAB of the genus Lactobacillus has become popular in recent years due to their ability to elicit strong systemic and mucosal immune responses. This article reviews Lactobacillus vaccine constructs, including Lactobacillus species, antigen expression, model organisms, and in vivo immune responses, with a primary focus on viral and bacterial antigens.
format	article
author	Jonathan S. LeCureux Gregg A. Dean
author_facet	Jonathan S. LeCureux Gregg A. Dean
author_sort	Jonathan S. LeCureux
title	<italic toggle="yes">Lactobacillus</italic> Mucosal Vaccine Vectors: Immune Responses against Bacterial and Viral Antigens
title_short	<italic toggle="yes">Lactobacillus</italic> Mucosal Vaccine Vectors: Immune Responses against Bacterial and Viral Antigens
title_full	<italic toggle="yes">Lactobacillus</italic> Mucosal Vaccine Vectors: Immune Responses against Bacterial and Viral Antigens
title_fullStr	<italic toggle="yes">Lactobacillus</italic> Mucosal Vaccine Vectors: Immune Responses against Bacterial and Viral Antigens
title_full_unstemmed	<italic toggle="yes">Lactobacillus</italic> Mucosal Vaccine Vectors: Immune Responses against Bacterial and Viral Antigens
title_sort	<italic toggle="yes">lactobacillus</italic> mucosal vaccine vectors: immune responses against bacterial and viral antigens
publisher	American Society for Microbiology
publishDate	2018
url	https://doaj.org/article/e43fffd460714771b64807f0e017b13e
work_keys_str_mv	AT jonathanslecureux italictoggleyeslactobacillusitalicmucosalvaccinevectorsimmuneresponsesagainstbacterialandviralantigens AT greggadean italictoggleyeslactobacillusitalicmucosalvaccinevectorsimmuneresponsesagainstbacterialandviralantigens
_version_	1718427981938950144

<italic toggle="yes">Lactobacillus</italic> Mucosal Vaccine Vectors: Immune Responses against Bacterial and Viral Antigens

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