Structural analyses of a constitutively active mutant of exchange protein directly activated by cAMP.

Structural analyses of a constitutively active mutant of exchange protein directly activated by cAMP.

Exchange proteins directly activated by cAMP (EPACs) are important allosteric regulators of cAMP-mediated signal transduction pathways. To understand the molecular mechanism of EPAC activation, we have combined site-directed mutagenesis, X-ray crystallography, and peptide amide hydrogen/deuterium ex...

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Autores principales: Mark A White, Sheng Li, Tamara Tsalkova, Fang C Mei, Tong Liu, Virgil L Woods, Xiaodong Cheng
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/e4407aa16482427d8aea4f83e9dc9941
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