Insc:LGN tetramers promote asymmetric divisions of mammary stem cells

Insc:LGN tetramers promote asymmetric divisions of mammary stem cells

During asymmetric divisions fate determinants and niche contacts segregate unequally between daughter cells, but the mechanism is unclear. Here the authors show that Insc:LGN tetramers promote assembly of Par3-Insc-LGN-GαiGDP complexes and asymmetric fate specification independently of microtubule m...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Simone Culurgioni, Sara Mari, Paola Bonetti, Sara Gallini, Greta Bonetto, Martha Brennich, Adam Round, Francesco Nicassio, Marina Mapelli
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/e44593885a164953a1d0c6b9547809f9
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:e44593885a164953a1d0c6b9547809f9
record_format dspace
spelling oai:doaj.org-article:e44593885a164953a1d0c6b9547809f92021-12-02T15:33:36ZInsc:LGN tetramers promote asymmetric divisions of mammary stem cells10.1038/s41467-018-03343-42041-1723https://doaj.org/article/e44593885a164953a1d0c6b9547809f92018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03343-4https://doaj.org/toc/2041-1723During asymmetric divisions fate determinants and niche contacts segregate unequally between daughter cells, but the mechanism is unclear. Here the authors show that Insc:LGN tetramers promote assembly of Par3-Insc-LGN-GαiGDP complexes and asymmetric fate specification independently of microtubule motors.Simone CulurgioniSara MariPaola BonettiSara GalliniGreta BonettoMartha BrennichAdam RoundFrancesco NicassioMarina MapelliNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Simone Culurgioni
Sara Mari
Paola Bonetti
Sara Gallini
Greta Bonetto
Martha Brennich
Adam Round
Francesco Nicassio
Marina Mapelli
Insc:LGN tetramers promote asymmetric divisions of mammary stem cells
description During asymmetric divisions fate determinants and niche contacts segregate unequally between daughter cells, but the mechanism is unclear. Here the authors show that Insc:LGN tetramers promote assembly of Par3-Insc-LGN-GαiGDP complexes and asymmetric fate specification independently of microtubule motors.
format article
author Simone Culurgioni
Sara Mari
Paola Bonetti
Sara Gallini
Greta Bonetto
Martha Brennich
Adam Round
Francesco Nicassio
Marina Mapelli
author_facet Simone Culurgioni
Sara Mari
Paola Bonetti
Sara Gallini
Greta Bonetto
Martha Brennich
Adam Round
Francesco Nicassio
Marina Mapelli
author_sort Simone Culurgioni
title Insc:LGN tetramers promote asymmetric divisions of mammary stem cells
title_short Insc:LGN tetramers promote asymmetric divisions of mammary stem cells
title_full Insc:LGN tetramers promote asymmetric divisions of mammary stem cells
title_fullStr Insc:LGN tetramers promote asymmetric divisions of mammary stem cells
title_full_unstemmed Insc:LGN tetramers promote asymmetric divisions of mammary stem cells
title_sort insc:lgn tetramers promote asymmetric divisions of mammary stem cells
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/e44593885a164953a1d0c6b9547809f9
work_keys_str_mv AT simoneculurgioni insclgntetramerspromoteasymmetricdivisionsofmammarystemcells
AT saramari insclgntetramerspromoteasymmetricdivisionsofmammarystemcells
AT paolabonetti insclgntetramerspromoteasymmetricdivisionsofmammarystemcells
AT saragallini insclgntetramerspromoteasymmetricdivisionsofmammarystemcells
AT gretabonetto insclgntetramerspromoteasymmetricdivisionsofmammarystemcells
AT marthabrennich insclgntetramerspromoteasymmetricdivisionsofmammarystemcells
AT adamround insclgntetramerspromoteasymmetricdivisionsofmammarystemcells
AT francesconicassio insclgntetramerspromoteasymmetricdivisionsofmammarystemcells
AT marinamapelli insclgntetramerspromoteasymmetricdivisionsofmammarystemcells
_version_ 1718387115704713216

Ejemplares similares