Novel animal model defines genetic contributions for neuron-to-neuron transfer of α-synuclein

Abstract Cell-to-cell spreading of misfolded α-synuclein (α-syn) is suggested to contribute to the progression of neuropathology in Parkinson’s disease (PD). Compelling evidence supports the hypothesis that misfolded α-syn transmits from neuron-to-neuron and seeds aggregation of the protein in the r...

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Autores principales: Trevor Tyson, Megan Senchuk, Jason F. Cooper, Sonia George, Jeremy M. Van Raamsdonk, Patrik Brundin
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/e44c58a75bc5424cab532651a38f2161
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