Engineered mRNA-expressed antibodies prevent respiratory syncytial virus infection

Engineered neutralizing antibodies are potential therapeutics for numerous viruses, such as respiratory syncytial virus (RSV). Here, the authors develop an mRNA-based approach to express membrane-anchored neutralizing antibodies in the lung and demonstrate that it inhibits RSV infections in mice.

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Autores principales:	Pooja Munnilal Tiwari, Daryll Vanover, Kevin E. Lindsay, Swapnil Subhash Bawage, Jonathan L. Kirschman, Sushma Bhosle, Aaron W. Lifland, Chiara Zurla, Philip J. Santangelo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e44ff193a36e4e31a23f1b866111b3ad
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spelling	oai:doaj.org-article:e44ff193a36e4e31a23f1b866111b3ad2021-12-02T15:34:39ZEngineered mRNA-expressed antibodies prevent respiratory syncytial virus infection10.1038/s41467-018-06508-32041-1723https://doaj.org/article/e44ff193a36e4e31a23f1b866111b3ad2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06508-3https://doaj.org/toc/2041-1723Engineered neutralizing antibodies are potential therapeutics for numerous viruses, such as respiratory syncytial virus (RSV). Here, the authors develop an mRNA-based approach to express membrane-anchored neutralizing antibodies in the lung and demonstrate that it inhibits RSV infections in mice.Pooja Munnilal TiwariDaryll VanoverKevin E. LindsaySwapnil Subhash BawageJonathan L. KirschmanSushma BhosleAaron W. LiflandChiara ZurlaPhilip J. SantangeloNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Pooja Munnilal Tiwari Daryll Vanover Kevin E. Lindsay Swapnil Subhash Bawage Jonathan L. Kirschman Sushma Bhosle Aaron W. Lifland Chiara Zurla Philip J. Santangelo Engineered mRNA-expressed antibodies prevent respiratory syncytial virus infection
description	Engineered neutralizing antibodies are potential therapeutics for numerous viruses, such as respiratory syncytial virus (RSV). Here, the authors develop an mRNA-based approach to express membrane-anchored neutralizing antibodies in the lung and demonstrate that it inhibits RSV infections in mice.
format	article
author	Pooja Munnilal Tiwari Daryll Vanover Kevin E. Lindsay Swapnil Subhash Bawage Jonathan L. Kirschman Sushma Bhosle Aaron W. Lifland Chiara Zurla Philip J. Santangelo
author_facet	Pooja Munnilal Tiwari Daryll Vanover Kevin E. Lindsay Swapnil Subhash Bawage Jonathan L. Kirschman Sushma Bhosle Aaron W. Lifland Chiara Zurla Philip J. Santangelo
author_sort	Pooja Munnilal Tiwari
title	Engineered mRNA-expressed antibodies prevent respiratory syncytial virus infection
title_short	Engineered mRNA-expressed antibodies prevent respiratory syncytial virus infection
title_full	Engineered mRNA-expressed antibodies prevent respiratory syncytial virus infection
title_fullStr	Engineered mRNA-expressed antibodies prevent respiratory syncytial virus infection
title_full_unstemmed	Engineered mRNA-expressed antibodies prevent respiratory syncytial virus infection
title_sort	engineered mrna-expressed antibodies prevent respiratory syncytial virus infection
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/e44ff193a36e4e31a23f1b866111b3ad
work_keys_str_mv	AT poojamunnilaltiwari engineeredmrnaexpressedantibodiespreventrespiratorysyncytialvirusinfection AT daryllvanover engineeredmrnaexpressedantibodiespreventrespiratorysyncytialvirusinfection AT kevinelindsay engineeredmrnaexpressedantibodiespreventrespiratorysyncytialvirusinfection AT swapnilsubhashbawage engineeredmrnaexpressedantibodiespreventrespiratorysyncytialvirusinfection AT jonathanlkirschman engineeredmrnaexpressedantibodiespreventrespiratorysyncytialvirusinfection AT sushmabhosle engineeredmrnaexpressedantibodiespreventrespiratorysyncytialvirusinfection AT aaronwlifland engineeredmrnaexpressedantibodiespreventrespiratorysyncytialvirusinfection AT chiarazurla engineeredmrnaexpressedantibodiespreventrespiratorysyncytialvirusinfection AT philipjsantangelo engineeredmrnaexpressedantibodiespreventrespiratorysyncytialvirusinfection
_version_	1718386812015083520

Engineered mRNA-expressed antibodies prevent respiratory syncytial virus infection

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