Association between medication adherence and health-related quality of life in patients with chronic obstructive pulmonary disease

Abstract Background Chronic Obstructive Pulmonary Disease (COPD) is one of the prominent cause of mortality worldwide. Nowadays, the level of medication adherence in COPD patients is very low, which reduces the clinical therapeutic effects. The purpose of the present study is to investigate the rela...

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Autores principales:	Boyuk Moradkhani, Samaneh Mollazadeh, Parastoo Niloofar, Afsaneh Bashiri, Mohammad Bagher Oghazian
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Chronic obstructive pulmonary disease Disease severity Health status Quality of life Medication adherence Therapeutics. Pharmacology RM1-950 Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/e44ff76df76a4889aa08c3e54608398b
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spelling	oai:doaj.org-article:e44ff76df76a4889aa08c3e54608398b2021-11-21T12:02:13ZAssociation between medication adherence and health-related quality of life in patients with chronic obstructive pulmonary disease10.1186/s40780-021-00222-x2055-0294https://doaj.org/article/e44ff76df76a4889aa08c3e54608398b2021-11-01T00:00:00Zhttps://doi.org/10.1186/s40780-021-00222-xhttps://doaj.org/toc/2055-0294Abstract Background Chronic Obstructive Pulmonary Disease (COPD) is one of the prominent cause of mortality worldwide. Nowadays, the level of medication adherence in COPD patients is very low, which reduces the clinical therapeutic effects. The purpose of the present study is to investigate the relationship between medication adherence and Health-Related Quality of Life (HRQoL) in COPD patients referred to the pulmonologist’s office. Methods This observational study was performed on 100 COPD outpatient cases. Each patient was interviewed to answer questionnaires regarding demographic and clinical information. To assess quality of life, health status, and severity of dyspnea, the St George’s Respiratory Questionnaire - COPD-Specific Version (SGRQ-C), COPD Assessment Test (CAT), and Modified British Medical Research Council (mMRC) questionnaires were used, respectively. Persian version of the Morisky Medication Adherence Scale (MMAS-8-Item) was used to measure medication adherence. To determine the adherence predictors, an ordinal logistic regression analysis was performed. Results Out of 100 patients with mean (±SD) age of 61.35 (±10.79) years, 74% had medium and high medication adherence. In the final ordinal logistic model, quality of life, health status, and education level found to have positive effect on medication adherence while polypharmacy had negative effect. We did not find any significant association between age, gender, Body Mass Index (BMI), and other variables with medication adherence. Conclusions Patients with high quality of life are more adherent to their medications. Furthermore, patients who have polypharmacy, tend to have less adherence to their medications.Boyuk MoradkhaniSamaneh MollazadehParastoo NiloofarAfsaneh BashiriMohammad Bagher OghazianBMCarticleChronic obstructive pulmonary diseaseDisease severityHealth statusQuality of lifeMedication adherenceTherapeutics. PharmacologyRM1-950Pharmacy and materia medicaRS1-441ENJournal of Pharmaceutical Health Care and Sciences, Vol 7, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Chronic obstructive pulmonary disease Disease severity Health status Quality of life Medication adherence Therapeutics. Pharmacology RM1-950 Pharmacy and materia medica RS1-441
spellingShingle	Chronic obstructive pulmonary disease Disease severity Health status Quality of life Medication adherence Therapeutics. Pharmacology RM1-950 Pharmacy and materia medica RS1-441 Boyuk Moradkhani Samaneh Mollazadeh Parastoo Niloofar Afsaneh Bashiri Mohammad Bagher Oghazian Association between medication adherence and health-related quality of life in patients with chronic obstructive pulmonary disease
description	Abstract Background Chronic Obstructive Pulmonary Disease (COPD) is one of the prominent cause of mortality worldwide. Nowadays, the level of medication adherence in COPD patients is very low, which reduces the clinical therapeutic effects. The purpose of the present study is to investigate the relationship between medication adherence and Health-Related Quality of Life (HRQoL) in COPD patients referred to the pulmonologist’s office. Methods This observational study was performed on 100 COPD outpatient cases. Each patient was interviewed to answer questionnaires regarding demographic and clinical information. To assess quality of life, health status, and severity of dyspnea, the St George’s Respiratory Questionnaire - COPD-Specific Version (SGRQ-C), COPD Assessment Test (CAT), and Modified British Medical Research Council (mMRC) questionnaires were used, respectively. Persian version of the Morisky Medication Adherence Scale (MMAS-8-Item) was used to measure medication adherence. To determine the adherence predictors, an ordinal logistic regression analysis was performed. Results Out of 100 patients with mean (±SD) age of 61.35 (±10.79) years, 74% had medium and high medication adherence. In the final ordinal logistic model, quality of life, health status, and education level found to have positive effect on medication adherence while polypharmacy had negative effect. We did not find any significant association between age, gender, Body Mass Index (BMI), and other variables with medication adherence. Conclusions Patients with high quality of life are more adherent to their medications. Furthermore, patients who have polypharmacy, tend to have less adherence to their medications.
format	article
author	Boyuk Moradkhani Samaneh Mollazadeh Parastoo Niloofar Afsaneh Bashiri Mohammad Bagher Oghazian
author_facet	Boyuk Moradkhani Samaneh Mollazadeh Parastoo Niloofar Afsaneh Bashiri Mohammad Bagher Oghazian
author_sort	Boyuk Moradkhani
title	Association between medication adherence and health-related quality of life in patients with chronic obstructive pulmonary disease
title_short	Association between medication adherence and health-related quality of life in patients with chronic obstructive pulmonary disease
title_full	Association between medication adherence and health-related quality of life in patients with chronic obstructive pulmonary disease
title_fullStr	Association between medication adherence and health-related quality of life in patients with chronic obstructive pulmonary disease
title_full_unstemmed	Association between medication adherence and health-related quality of life in patients with chronic obstructive pulmonary disease
title_sort	association between medication adherence and health-related quality of life in patients with chronic obstructive pulmonary disease
publisher	BMC
publishDate	2021
url	https://doaj.org/article/e44ff76df76a4889aa08c3e54608398b
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Association between medication adherence and health-related quality of life in patients with chronic obstructive pulmonary disease

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