Bacterial communities of the coronal sulcus and distal urethra of adolescent males.

Lactobacillus-dominated vaginal microbiotas are associated with reproductive health and STI resistance in women, whereas altered microbiotas are associated with bacterial vaginosis (BV), STI risk and poor reproductive outcomes. Putative vaginal taxa have been observed in male first-catch urine, uret...

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Autores principales:	David E Nelson, Qunfeng Dong, Barbara Van der Pol, Evelyn Toh, Baochang Fan, Barry P Katz, Deming Mi, Ruichen Rong, George M Weinstock, Erica Sodergren, J Dennis Fortenberry
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e45289261e6141e68c8be1061384fc41
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spelling	oai:doaj.org-article:e45289261e6141e68c8be1061384fc412021-11-18T07:19:02ZBacterial communities of the coronal sulcus and distal urethra of adolescent males.1932-620310.1371/journal.pone.0036298https://doaj.org/article/e45289261e6141e68c8be1061384fc412012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22606251/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Lactobacillus-dominated vaginal microbiotas are associated with reproductive health and STI resistance in women, whereas altered microbiotas are associated with bacterial vaginosis (BV), STI risk and poor reproductive outcomes. Putative vaginal taxa have been observed in male first-catch urine, urethral swab and coronal sulcus (CS) specimens but the significance of these observations is unclear. We used 16 S rRNA sequencing to characterize the microbiota of the CS and urine collected from 18 adolescent men over three consecutive months. CS microbiotas of most participants were more stable than their urine microbiotas and the composition of CS microbiotas were strongly influenced by circumcision. BV-associated taxa, including Atopobium, Megasphaera, Mobiluncus, Prevotella and Gemella, were detected in CS specimens from sexually experienced and inexperienced participants. In contrast, urine primarily contained taxa that were not abundant in CS specimens. Lactobacilllus and Streptococcus were major urine taxa but their abundance was inversely correlated. In contrast, Sneathia, Mycoplasma and Ureaplasma were only found in urine from sexually active participants. Thus, the CS and urine support stable and distinct bacterial communities. Finally, our results suggest that the penis and the urethra can be colonized by a variety of BV-associated taxa and that some of these colonizations result from partnered sexual activity.David E NelsonQunfeng DongBarbara Van der PolEvelyn TohBaochang FanBarry P KatzDeming MiRuichen RongGeorge M WeinstockErica SodergrenJ Dennis FortenberryPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 5, p e36298 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q David E Nelson Qunfeng Dong Barbara Van der Pol Evelyn Toh Baochang Fan Barry P Katz Deming Mi Ruichen Rong George M Weinstock Erica Sodergren J Dennis Fortenberry Bacterial communities of the coronal sulcus and distal urethra of adolescent males.
description	Lactobacillus-dominated vaginal microbiotas are associated with reproductive health and STI resistance in women, whereas altered microbiotas are associated with bacterial vaginosis (BV), STI risk and poor reproductive outcomes. Putative vaginal taxa have been observed in male first-catch urine, urethral swab and coronal sulcus (CS) specimens but the significance of these observations is unclear. We used 16 S rRNA sequencing to characterize the microbiota of the CS and urine collected from 18 adolescent men over three consecutive months. CS microbiotas of most participants were more stable than their urine microbiotas and the composition of CS microbiotas were strongly influenced by circumcision. BV-associated taxa, including Atopobium, Megasphaera, Mobiluncus, Prevotella and Gemella, were detected in CS specimens from sexually experienced and inexperienced participants. In contrast, urine primarily contained taxa that were not abundant in CS specimens. Lactobacilllus and Streptococcus were major urine taxa but their abundance was inversely correlated. In contrast, Sneathia, Mycoplasma and Ureaplasma were only found in urine from sexually active participants. Thus, the CS and urine support stable and distinct bacterial communities. Finally, our results suggest that the penis and the urethra can be colonized by a variety of BV-associated taxa and that some of these colonizations result from partnered sexual activity.
format	article
author	David E Nelson Qunfeng Dong Barbara Van der Pol Evelyn Toh Baochang Fan Barry P Katz Deming Mi Ruichen Rong George M Weinstock Erica Sodergren J Dennis Fortenberry
author_facet	David E Nelson Qunfeng Dong Barbara Van der Pol Evelyn Toh Baochang Fan Barry P Katz Deming Mi Ruichen Rong George M Weinstock Erica Sodergren J Dennis Fortenberry
author_sort	David E Nelson
title	Bacterial communities of the coronal sulcus and distal urethra of adolescent males.
title_short	Bacterial communities of the coronal sulcus and distal urethra of adolescent males.
title_full	Bacterial communities of the coronal sulcus and distal urethra of adolescent males.
title_fullStr	Bacterial communities of the coronal sulcus and distal urethra of adolescent males.
title_full_unstemmed	Bacterial communities of the coronal sulcus and distal urethra of adolescent males.
title_sort	bacterial communities of the coronal sulcus and distal urethra of adolescent males.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/e45289261e6141e68c8be1061384fc41
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Bacterial communities of the coronal sulcus and distal urethra of adolescent males.

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