Neuromodulation and neuroprotective effects of chlorogenic acids in excitatory synapses of mouse hippocampal slices

Abstract The increased healthspan afforded by coffee intake provides novel opportunities to identify new therapeutic strategies. Caffeine has been proposed to afford benefits through adenosine A2A receptors, which can control synaptic dysfunction underlying some brain disease. However, decaffeinated...

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Autores principales:	Mara Yone D. Fernandes, Fernando Dobrachinski, Henrique B. Silva, João Pedro Lopes, Francisco Q. Gonçalves, Felix A. A. Soares, Lisiane O. Porciúncula, Geanne M. Andrade, Rodrigo A. Cunha, Angelo R. Tomé
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e4562b728f2f4c6e95a8ba831eba7f7f
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spelling	oai:doaj.org-article:e4562b728f2f4c6e95a8ba831eba7f7f2021-12-02T15:45:16ZNeuromodulation and neuroprotective effects of chlorogenic acids in excitatory synapses of mouse hippocampal slices10.1038/s41598-021-89964-02045-2322https://doaj.org/article/e4562b728f2f4c6e95a8ba831eba7f7f2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89964-0https://doaj.org/toc/2045-2322Abstract The increased healthspan afforded by coffee intake provides novel opportunities to identify new therapeutic strategies. Caffeine has been proposed to afford benefits through adenosine A2A receptors, which can control synaptic dysfunction underlying some brain disease. However, decaffeinated coffee and other main components of coffee such as chlorogenic acids, also attenuate brain dysfunction, although it is unknown if they control synaptic function. We now used electrophysiological recordings in mouse hippocampal slices to test if realistic concentrations of chlorogenic acids directly affect synaptic transmission and plasticity. 3-(3,4-dihydroxycinnamoyl)quinic acid (CA, 1–10 μM) and 5-O-(trans-3,4-dihydroxycinnamoyl)-D-quinic acid (NCA, 1–10 μM) were devoid of effect on synaptic transmission, paired-pulse facilitation or long-term potentiation (LTP) and long-term depression (LTD) in Schaffer collaterals-CA1 pyramidal synapses. However, CA and NCA increased the recovery of synaptic transmission upon re-oxygenation following 7 min of oxygen/glucose deprivation, an in vitro ischemia model. Also, CA and NCA attenuated the shift of LTD into LTP observed in hippocampal slices from animals with hippocampal-dependent memory deterioration after exposure to β-amyloid 1–42 (2 nmol, icv), in the context of Alzheimer’s disease. These findings show that chlorogenic acids do not directly affect synaptic transmission and plasticity but can indirectly affect other cellular targets to correct synaptic dysfunction. Unraveling the molecular mechanisms of action of chlorogenic acids will allow the design of hitherto unrecognized novel neuroprotective strategies.Mara Yone D. FernandesFernando DobrachinskiHenrique B. SilvaJoão Pedro LopesFrancisco Q. GonçalvesFelix A. A. SoaresLisiane O. PorciúnculaGeanne M. AndradeRodrigo A. CunhaAngelo R. ToméNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mara Yone D. Fernandes Fernando Dobrachinski Henrique B. Silva João Pedro Lopes Francisco Q. Gonçalves Felix A. A. Soares Lisiane O. Porciúncula Geanne M. Andrade Rodrigo A. Cunha Angelo R. Tomé Neuromodulation and neuroprotective effects of chlorogenic acids in excitatory synapses of mouse hippocampal slices
description	Abstract The increased healthspan afforded by coffee intake provides novel opportunities to identify new therapeutic strategies. Caffeine has been proposed to afford benefits through adenosine A2A receptors, which can control synaptic dysfunction underlying some brain disease. However, decaffeinated coffee and other main components of coffee such as chlorogenic acids, also attenuate brain dysfunction, although it is unknown if they control synaptic function. We now used electrophysiological recordings in mouse hippocampal slices to test if realistic concentrations of chlorogenic acids directly affect synaptic transmission and plasticity. 3-(3,4-dihydroxycinnamoyl)quinic acid (CA, 1–10 μM) and 5-O-(trans-3,4-dihydroxycinnamoyl)-D-quinic acid (NCA, 1–10 μM) were devoid of effect on synaptic transmission, paired-pulse facilitation or long-term potentiation (LTP) and long-term depression (LTD) in Schaffer collaterals-CA1 pyramidal synapses. However, CA and NCA increased the recovery of synaptic transmission upon re-oxygenation following 7 min of oxygen/glucose deprivation, an in vitro ischemia model. Also, CA and NCA attenuated the shift of LTD into LTP observed in hippocampal slices from animals with hippocampal-dependent memory deterioration after exposure to β-amyloid 1–42 (2 nmol, icv), in the context of Alzheimer’s disease. These findings show that chlorogenic acids do not directly affect synaptic transmission and plasticity but can indirectly affect other cellular targets to correct synaptic dysfunction. Unraveling the molecular mechanisms of action of chlorogenic acids will allow the design of hitherto unrecognized novel neuroprotective strategies.
format	article
author	Mara Yone D. Fernandes Fernando Dobrachinski Henrique B. Silva João Pedro Lopes Francisco Q. Gonçalves Felix A. A. Soares Lisiane O. Porciúncula Geanne M. Andrade Rodrigo A. Cunha Angelo R. Tomé
author_facet	Mara Yone D. Fernandes Fernando Dobrachinski Henrique B. Silva João Pedro Lopes Francisco Q. Gonçalves Felix A. A. Soares Lisiane O. Porciúncula Geanne M. Andrade Rodrigo A. Cunha Angelo R. Tomé
author_sort	Mara Yone D. Fernandes
title	Neuromodulation and neuroprotective effects of chlorogenic acids in excitatory synapses of mouse hippocampal slices
title_short	Neuromodulation and neuroprotective effects of chlorogenic acids in excitatory synapses of mouse hippocampal slices
title_full	Neuromodulation and neuroprotective effects of chlorogenic acids in excitatory synapses of mouse hippocampal slices
title_fullStr	Neuromodulation and neuroprotective effects of chlorogenic acids in excitatory synapses of mouse hippocampal slices
title_full_unstemmed	Neuromodulation and neuroprotective effects of chlorogenic acids in excitatory synapses of mouse hippocampal slices
title_sort	neuromodulation and neuroprotective effects of chlorogenic acids in excitatory synapses of mouse hippocampal slices
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e4562b728f2f4c6e95a8ba831eba7f7f
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Neuromodulation and neuroprotective effects of chlorogenic acids in excitatory synapses of mouse hippocampal slices

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