Synthesis, and characterization of some Cu(I) complexes having propionitrile and pyridine moieties: An investigation on their antibacterial properties

The aim of producing new biologically active compounds lead to the synthesis of some Cu(I) complexes of general formula [Cu(C2H5CN)4][A] and [Cu(C5H5N)4][A] (1–4) {where A: counter anion = B(C6F5)4− and B{C6H3(m-CF3)2}4−} from the reaction of CuCl and silver salt of the corresponding counter anion....

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Autores principales:	Ahmed K. Hijazi, Ziyad A. Taha, Nisreen J. Abuhamad, Waleed M. Al-Momani
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	MIC Antibacterial Cu(I) complexes Pyridine Propionitrile Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/e458b3d79ab64c50b126f904b5b0327c
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spelling	oai:doaj.org-article:e458b3d79ab64c50b126f904b5b0327c2021-11-22T04:19:47ZSynthesis, and characterization of some Cu(I) complexes having propionitrile and pyridine moieties: An investigation on their antibacterial properties1319-610310.1016/j.jscs.2021.101387https://doaj.org/article/e458b3d79ab64c50b126f904b5b0327c2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1319610321001927https://doaj.org/toc/1319-6103The aim of producing new biologically active compounds lead to the synthesis of some Cu(I) complexes of general formula [Cu(C2H5CN)4][A] and [Cu(C5H5N)4][A] (1–4) {where A: counter anion = B(C6F5)4− and B{C6H3(m-CF3)2}4−} from the reaction of CuCl and silver salt of the corresponding counter anion. The complexes were characterized using elemental analysis, 1H NMR, 11B NMR, FT-IR Spectroscopy, UV–visible spectroscopy and thermo-gravimetric analysis (TGA). The antibacterial activities of all complexes are evaluated by the minimal inhibitory concentration (MIC), using the micro-broth dilution method, against eight bacteria (Gram-negative and Gram-positive), each with fresh clinical isolates. The MIC results were compared with those of Oxytetracycline agent as a positive control. In most cases, the compounds show broad-spectrum activities that were either, more active, or equipotent to, the antibiotic agent in the comparison tests. Complex 4 showed the greatest activity against Proteus mirabilis (Gram- negative) with a minimum inhibitory concentration (MIC) of 8 µg/mL, while complexes 2 and 3 showed the lowest activity against Pseudomonas aeruginosa (Gram-negative) and against Staphylococcus aureus (Gram-positive) with a concentration of 512 µg/mL.Ahmed K. HijaziZiyad A. TahaNisreen J. AbuhamadWaleed M. Al-MomaniElsevierarticleMICAntibacterialCu(I) complexesPyridinePropionitrileChemistryQD1-999ENJournal of Saudi Chemical Society, Vol 25, Iss 12, Pp 101387- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	MIC Antibacterial Cu(I) complexes Pyridine Propionitrile Chemistry QD1-999
spellingShingle	MIC Antibacterial Cu(I) complexes Pyridine Propionitrile Chemistry QD1-999 Ahmed K. Hijazi Ziyad A. Taha Nisreen J. Abuhamad Waleed M. Al-Momani Synthesis, and characterization of some Cu(I) complexes having propionitrile and pyridine moieties: An investigation on their antibacterial properties
description	The aim of producing new biologically active compounds lead to the synthesis of some Cu(I) complexes of general formula [Cu(C2H5CN)4][A] and [Cu(C5H5N)4][A] (1–4) {where A: counter anion = B(C6F5)4− and B{C6H3(m-CF3)2}4−} from the reaction of CuCl and silver salt of the corresponding counter anion. The complexes were characterized using elemental analysis, 1H NMR, 11B NMR, FT-IR Spectroscopy, UV–visible spectroscopy and thermo-gravimetric analysis (TGA). The antibacterial activities of all complexes are evaluated by the minimal inhibitory concentration (MIC), using the micro-broth dilution method, against eight bacteria (Gram-negative and Gram-positive), each with fresh clinical isolates. The MIC results were compared with those of Oxytetracycline agent as a positive control. In most cases, the compounds show broad-spectrum activities that were either, more active, or equipotent to, the antibiotic agent in the comparison tests. Complex 4 showed the greatest activity against Proteus mirabilis (Gram- negative) with a minimum inhibitory concentration (MIC) of 8 µg/mL, while complexes 2 and 3 showed the lowest activity against Pseudomonas aeruginosa (Gram-negative) and against Staphylococcus aureus (Gram-positive) with a concentration of 512 µg/mL.
format	article
author	Ahmed K. Hijazi Ziyad A. Taha Nisreen J. Abuhamad Waleed M. Al-Momani
author_facet	Ahmed K. Hijazi Ziyad A. Taha Nisreen J. Abuhamad Waleed M. Al-Momani
author_sort	Ahmed K. Hijazi
title	Synthesis, and characterization of some Cu(I) complexes having propionitrile and pyridine moieties: An investigation on their antibacterial properties
title_short	Synthesis, and characterization of some Cu(I) complexes having propionitrile and pyridine moieties: An investigation on their antibacterial properties
title_full	Synthesis, and characterization of some Cu(I) complexes having propionitrile and pyridine moieties: An investigation on their antibacterial properties
title_fullStr	Synthesis, and characterization of some Cu(I) complexes having propionitrile and pyridine moieties: An investigation on their antibacterial properties
title_full_unstemmed	Synthesis, and characterization of some Cu(I) complexes having propionitrile and pyridine moieties: An investigation on their antibacterial properties
title_sort	synthesis, and characterization of some cu(i) complexes having propionitrile and pyridine moieties: an investigation on their antibacterial properties
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/e458b3d79ab64c50b126f904b5b0327c
work_keys_str_mv	AT ahmedkhijazi synthesisandcharacterizationofsomecuicomplexeshavingpropionitrileandpyridinemoietiesaninvestigationontheirantibacterialproperties AT ziyadataha synthesisandcharacterizationofsomecuicomplexeshavingpropionitrileandpyridinemoietiesaninvestigationontheirantibacterialproperties AT nisreenjabuhamad synthesisandcharacterizationofsomecuicomplexeshavingpropionitrileandpyridinemoietiesaninvestigationontheirantibacterialproperties AT waleedmalmomani synthesisandcharacterizationofsomecuicomplexeshavingpropionitrileandpyridinemoietiesaninvestigationontheirantibacterialproperties
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Synthesis, and characterization of some Cu(I) complexes having propionitrile and pyridine moieties: An investigation on their antibacterial properties

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