PAX8 and MECOM are interaction partners driving ovarian cancer
Lineage-restricted transcription factor PAX8 is oncogenic in ovarian cancer cells. Here the authors show that PAX8 interacts and recruits a splice variant of the MECOM locus PRDM3 to control the gene expression module involved in adhesion and extracellular matrix, and consequently promotes ovarian t...
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Nature Portfolio
2021
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| Acceso en línea: | https://doaj.org/article/e459f346777c48fab385e6b2235f6c4c |
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oai:doaj.org-article:e459f346777c48fab385e6b2235f6c4c2021-12-02T16:55:53ZPAX8 and MECOM are interaction partners driving ovarian cancer10.1038/s41467-021-22708-w2041-1723https://doaj.org/article/e459f346777c48fab385e6b2235f6c4c2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22708-whttps://doaj.org/toc/2041-1723Lineage-restricted transcription factor PAX8 is oncogenic in ovarian cancer cells. Here the authors show that PAX8 interacts and recruits a splice variant of the MECOM locus PRDM3 to control the gene expression module involved in adhesion and extracellular matrix, and consequently promotes ovarian tumorigenesis.Melusine BleuFanny Mermet-MeillonVerena ApfelLouise BarysLaura HolzerMarianne Bachmann SalvyRui LopesInês Amorim Monteiro BarbosaCecile DelmasAlexandra HinnigerSuzanne ChauMarkus KaufmannSimon HaenniKarolin BerneiserMaria WahleIvana MoravecAlexandra VissièresTania PoetschErik AhrnéNathalie CarteJohannes VosholElisabeth BechterJacques HamonMarco MeyerhoferDirk ErdmannMatteo FischerTherese StachyraFelix FreulerSascha GutmannCésar FernándezTobias SchmelzleUlrike NaumannGuglielmo RomaKate LawrensonCristina Nieto-OberhuberAmanda Cobos-CorreaStephane FerrettiDirk SchübelerGiorgio Giacomo GalliNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
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Science Q Melusine Bleu Fanny Mermet-Meillon Verena Apfel Louise Barys Laura Holzer Marianne Bachmann Salvy Rui Lopes Inês Amorim Monteiro Barbosa Cecile Delmas Alexandra Hinniger Suzanne Chau Markus Kaufmann Simon Haenni Karolin Berneiser Maria Wahle Ivana Moravec Alexandra Vissières Tania Poetsch Erik Ahrné Nathalie Carte Johannes Voshol Elisabeth Bechter Jacques Hamon Marco Meyerhofer Dirk Erdmann Matteo Fischer Therese Stachyra Felix Freuler Sascha Gutmann César Fernández Tobias Schmelzle Ulrike Naumann Guglielmo Roma Kate Lawrenson Cristina Nieto-Oberhuber Amanda Cobos-Correa Stephane Ferretti Dirk Schübeler Giorgio Giacomo Galli PAX8 and MECOM are interaction partners driving ovarian cancer |
| description |
Lineage-restricted transcription factor PAX8 is oncogenic in ovarian cancer cells. Here the authors show that PAX8 interacts and recruits a splice variant of the MECOM locus PRDM3 to control the gene expression module involved in adhesion and extracellular matrix, and consequently promotes ovarian tumorigenesis. |
| format |
article |
| author |
Melusine Bleu Fanny Mermet-Meillon Verena Apfel Louise Barys Laura Holzer Marianne Bachmann Salvy Rui Lopes Inês Amorim Monteiro Barbosa Cecile Delmas Alexandra Hinniger Suzanne Chau Markus Kaufmann Simon Haenni Karolin Berneiser Maria Wahle Ivana Moravec Alexandra Vissières Tania Poetsch Erik Ahrné Nathalie Carte Johannes Voshol Elisabeth Bechter Jacques Hamon Marco Meyerhofer Dirk Erdmann Matteo Fischer Therese Stachyra Felix Freuler Sascha Gutmann César Fernández Tobias Schmelzle Ulrike Naumann Guglielmo Roma Kate Lawrenson Cristina Nieto-Oberhuber Amanda Cobos-Correa Stephane Ferretti Dirk Schübeler Giorgio Giacomo Galli |
| author_facet |
Melusine Bleu Fanny Mermet-Meillon Verena Apfel Louise Barys Laura Holzer Marianne Bachmann Salvy Rui Lopes Inês Amorim Monteiro Barbosa Cecile Delmas Alexandra Hinniger Suzanne Chau Markus Kaufmann Simon Haenni Karolin Berneiser Maria Wahle Ivana Moravec Alexandra Vissières Tania Poetsch Erik Ahrné Nathalie Carte Johannes Voshol Elisabeth Bechter Jacques Hamon Marco Meyerhofer Dirk Erdmann Matteo Fischer Therese Stachyra Felix Freuler Sascha Gutmann César Fernández Tobias Schmelzle Ulrike Naumann Guglielmo Roma Kate Lawrenson Cristina Nieto-Oberhuber Amanda Cobos-Correa Stephane Ferretti Dirk Schübeler Giorgio Giacomo Galli |
| author_sort |
Melusine Bleu |
| title |
PAX8 and MECOM are interaction partners driving ovarian cancer |
| title_short |
PAX8 and MECOM are interaction partners driving ovarian cancer |
| title_full |
PAX8 and MECOM are interaction partners driving ovarian cancer |
| title_fullStr |
PAX8 and MECOM are interaction partners driving ovarian cancer |
| title_full_unstemmed |
PAX8 and MECOM are interaction partners driving ovarian cancer |
| title_sort |
pax8 and mecom are interaction partners driving ovarian cancer |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/e459f346777c48fab385e6b2235f6c4c |
| work_keys_str_mv |
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1718382831921528832 |