Structure-based design of native-like HIV-1 envelope trimers to silence non-neutralizing epitopes and eliminate CD4 binding
Eliciting broadly neutralizing antibodies (bnAbs) is a primary HIV vaccine goal, but available immunogens expose epitopes for development of non-nAbs. Here, the authors use computational and structure-guided design to develop improved native-like envelope trimers and analyze Ab response in animal mo...
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Nature Portfolio
2017
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oai:doaj.org-article:e45b30de0325403bb21de6e2ce224daa2021-12-02T15:38:32ZStructure-based design of native-like HIV-1 envelope trimers to silence non-neutralizing epitopes and eliminate CD4 binding10.1038/s41467-017-01549-62041-1723https://doaj.org/article/e45b30de0325403bb21de6e2ce224daa2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01549-6https://doaj.org/toc/2041-1723Eliciting broadly neutralizing antibodies (bnAbs) is a primary HIV vaccine goal, but available immunogens expose epitopes for development of non-nAbs. Here, the authors use computational and structure-guided design to develop improved native-like envelope trimers and analyze Ab response in animal models.Daniel W. KulpJon M. SteichenMatthias PauthnerXiaozhen HuTorben SchiffnerAlessia LiguoriChristopher A. CottrellColin Havenar-DaughtonGabriel OzorowskiErik GeorgesonOleksandr KalyuzhniyJordan R. WillisMichael KubitzYumiko AdachiSamantha M. ReissMia ShinNatalia de ValAndrew B. WardShane CrottyDennis R. BurtonWilliam R. SchiefNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017) |
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| topic |
Science Q |
| spellingShingle |
Science Q Daniel W. Kulp Jon M. Steichen Matthias Pauthner Xiaozhen Hu Torben Schiffner Alessia Liguori Christopher A. Cottrell Colin Havenar-Daughton Gabriel Ozorowski Erik Georgeson Oleksandr Kalyuzhniy Jordan R. Willis Michael Kubitz Yumiko Adachi Samantha M. Reiss Mia Shin Natalia de Val Andrew B. Ward Shane Crotty Dennis R. Burton William R. Schief Structure-based design of native-like HIV-1 envelope trimers to silence non-neutralizing epitopes and eliminate CD4 binding |
| description |
Eliciting broadly neutralizing antibodies (bnAbs) is a primary HIV vaccine goal, but available immunogens expose epitopes for development of non-nAbs. Here, the authors use computational and structure-guided design to develop improved native-like envelope trimers and analyze Ab response in animal models. |
| format |
article |
| author |
Daniel W. Kulp Jon M. Steichen Matthias Pauthner Xiaozhen Hu Torben Schiffner Alessia Liguori Christopher A. Cottrell Colin Havenar-Daughton Gabriel Ozorowski Erik Georgeson Oleksandr Kalyuzhniy Jordan R. Willis Michael Kubitz Yumiko Adachi Samantha M. Reiss Mia Shin Natalia de Val Andrew B. Ward Shane Crotty Dennis R. Burton William R. Schief |
| author_facet |
Daniel W. Kulp Jon M. Steichen Matthias Pauthner Xiaozhen Hu Torben Schiffner Alessia Liguori Christopher A. Cottrell Colin Havenar-Daughton Gabriel Ozorowski Erik Georgeson Oleksandr Kalyuzhniy Jordan R. Willis Michael Kubitz Yumiko Adachi Samantha M. Reiss Mia Shin Natalia de Val Andrew B. Ward Shane Crotty Dennis R. Burton William R. Schief |
| author_sort |
Daniel W. Kulp |
| title |
Structure-based design of native-like HIV-1 envelope trimers to silence non-neutralizing epitopes and eliminate CD4 binding |
| title_short |
Structure-based design of native-like HIV-1 envelope trimers to silence non-neutralizing epitopes and eliminate CD4 binding |
| title_full |
Structure-based design of native-like HIV-1 envelope trimers to silence non-neutralizing epitopes and eliminate CD4 binding |
| title_fullStr |
Structure-based design of native-like HIV-1 envelope trimers to silence non-neutralizing epitopes and eliminate CD4 binding |
| title_full_unstemmed |
Structure-based design of native-like HIV-1 envelope trimers to silence non-neutralizing epitopes and eliminate CD4 binding |
| title_sort |
structure-based design of native-like hiv-1 envelope trimers to silence non-neutralizing epitopes and eliminate cd4 binding |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/e45b30de0325403bb21de6e2ce224daa |
| work_keys_str_mv |
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