Aspirin Alleviates Particulate Matter Induced Asymptomatic Orchitis of Mice via Suppression of cGAS-STING Signaling
As an important source of air pollutant, airborne particulate matter (PM) has become a major threat to public health. Orchitis is characterized by acute or chronic testicular inflammation and is a primary cause of male infertility. Although accumulating evidence indicates that PM exposure is associa...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:e45f5ba762d847fd925f760e9f8e78a32021-12-01T22:14:46ZAspirin Alleviates Particulate Matter Induced Asymptomatic Orchitis of Mice via Suppression of cGAS-STING Signaling1664-322410.3389/fimmu.2021.734546https://doaj.org/article/e45f5ba762d847fd925f760e9f8e78a32021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.734546/fullhttps://doaj.org/toc/1664-3224As an important source of air pollutant, airborne particulate matter (PM) has become a major threat to public health. Orchitis is characterized by acute or chronic testicular inflammation and is a primary cause of male infertility. Although accumulating evidence indicates that PM exposure is associated with increased male infertility rates, the mechanism by which PM is involved is not well understood. Here, we found that short-term PM exposure activated NF-κB signaling in mouse Leydig cells and testes and leading to asymptomatic orchitis. Analyzing the mitochondrial abundance and cGAMP levels in PM exposed mouse Leydig cells, we found that PM exposure induced mitochondrial injury and mtDNA release, leading to inflammation via the cGAS-STING axis. We also found that aspirin-induced acetylation of cGAS inhibited the inflammation in mice after PM exposure, especially in the testes. Moreover, aspirin pretreatment rescued offspring growth in PM-exposed mice. In summary, our study not only provides evidence that PM-induced asymptomatic orchitis in mice may be amenable to aspirin pre-treatment by acetylating cGAS, but also provides a potential explanation for male infertility caused by air pollutants.Tengyu ZhuTengyu ZhuTengyu ZhuXue ChenXue ChenHuan QiuHuan QiuYang LiuYang LiuJames MwangiJames MwangiLing ZhaoWenjun DingRen LaiRen LaiRen LaiLin JinLin JinFrontiers Media S.A.articlemale infertilityparticulate matterorchitisaspirincGAS-STING pathwayImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021) |
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DOAJ |
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| topic |
male infertility particulate matter orchitis aspirin cGAS-STING pathway Immunologic diseases. Allergy RC581-607 |
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male infertility particulate matter orchitis aspirin cGAS-STING pathway Immunologic diseases. Allergy RC581-607 Tengyu Zhu Tengyu Zhu Tengyu Zhu Xue Chen Xue Chen Huan Qiu Huan Qiu Yang Liu Yang Liu James Mwangi James Mwangi Ling Zhao Wenjun Ding Ren Lai Ren Lai Ren Lai Lin Jin Lin Jin Aspirin Alleviates Particulate Matter Induced Asymptomatic Orchitis of Mice via Suppression of cGAS-STING Signaling |
| description |
As an important source of air pollutant, airborne particulate matter (PM) has become a major threat to public health. Orchitis is characterized by acute or chronic testicular inflammation and is a primary cause of male infertility. Although accumulating evidence indicates that PM exposure is associated with increased male infertility rates, the mechanism by which PM is involved is not well understood. Here, we found that short-term PM exposure activated NF-κB signaling in mouse Leydig cells and testes and leading to asymptomatic orchitis. Analyzing the mitochondrial abundance and cGAMP levels in PM exposed mouse Leydig cells, we found that PM exposure induced mitochondrial injury and mtDNA release, leading to inflammation via the cGAS-STING axis. We also found that aspirin-induced acetylation of cGAS inhibited the inflammation in mice after PM exposure, especially in the testes. Moreover, aspirin pretreatment rescued offspring growth in PM-exposed mice. In summary, our study not only provides evidence that PM-induced asymptomatic orchitis in mice may be amenable to aspirin pre-treatment by acetylating cGAS, but also provides a potential explanation for male infertility caused by air pollutants. |
| format |
article |
| author |
Tengyu Zhu Tengyu Zhu Tengyu Zhu Xue Chen Xue Chen Huan Qiu Huan Qiu Yang Liu Yang Liu James Mwangi James Mwangi Ling Zhao Wenjun Ding Ren Lai Ren Lai Ren Lai Lin Jin Lin Jin |
| author_facet |
Tengyu Zhu Tengyu Zhu Tengyu Zhu Xue Chen Xue Chen Huan Qiu Huan Qiu Yang Liu Yang Liu James Mwangi James Mwangi Ling Zhao Wenjun Ding Ren Lai Ren Lai Ren Lai Lin Jin Lin Jin |
| author_sort |
Tengyu Zhu |
| title |
Aspirin Alleviates Particulate Matter Induced Asymptomatic Orchitis of Mice via Suppression of cGAS-STING Signaling |
| title_short |
Aspirin Alleviates Particulate Matter Induced Asymptomatic Orchitis of Mice via Suppression of cGAS-STING Signaling |
| title_full |
Aspirin Alleviates Particulate Matter Induced Asymptomatic Orchitis of Mice via Suppression of cGAS-STING Signaling |
| title_fullStr |
Aspirin Alleviates Particulate Matter Induced Asymptomatic Orchitis of Mice via Suppression of cGAS-STING Signaling |
| title_full_unstemmed |
Aspirin Alleviates Particulate Matter Induced Asymptomatic Orchitis of Mice via Suppression of cGAS-STING Signaling |
| title_sort |
aspirin alleviates particulate matter induced asymptomatic orchitis of mice via suppression of cgas-sting signaling |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/e45f5ba762d847fd925f760e9f8e78a3 |
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