Human pre-valvular endocardial cells derived from pluripotent stem cells recapitulate cardiac pathophysiological valvulogenesis

There are few human models that can recapitulate valve development in vitro. Here, the authors derive human pre-valvular endocardial cells (HPVCs) from iPSCs and show they can recapitulate early valvulogenesis, and patient derived HPVCs have features of mitral valve prolapse and identified SHH dysre...

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Autores principales:	Tui Neri, Emilye Hiriart, Patrick P. van Vliet, Emilie Faure, Russell A. Norris, Batoul Farhat, Bernd Jagla, Julie Lefrancois, Yukiko Sugi, Thomas Moore-Morris, Stéphane Zaffran, Randolph S. Faustino, Alexander C. Zambon, Jean-Pierre Desvignes, David Salgado, Robert A. Levine, Jose Luis de la Pompa, André Terzic, Sylvia M. Evans, Roger Markwald, Michel Pucéat
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e45f606ce5c6400ca0225b4e0d2ad5be
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spelling	oai:doaj.org-article:e45f606ce5c6400ca0225b4e0d2ad5be2021-12-02T14:35:37ZHuman pre-valvular endocardial cells derived from pluripotent stem cells recapitulate cardiac pathophysiological valvulogenesis10.1038/s41467-019-09459-52041-1723https://doaj.org/article/e45f606ce5c6400ca0225b4e0d2ad5be2019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09459-5https://doaj.org/toc/2041-1723There are few human models that can recapitulate valve development in vitro. Here, the authors derive human pre-valvular endocardial cells (HPVCs) from iPSCs and show they can recapitulate early valvulogenesis, and patient derived HPVCs have features of mitral valve prolapse and identified SHH dysregulation.Tui NeriEmilye HiriartPatrick P. van VlietEmilie FaureRussell A. NorrisBatoul FarhatBernd JaglaJulie LefrancoisYukiko SugiThomas Moore-MorrisStéphane ZaffranRandolph S. FaustinoAlexander C. ZambonJean-Pierre DesvignesDavid SalgadoRobert A. LevineJose Luis de la PompaAndré TerzicSylvia M. EvansRoger MarkwaldMichel PucéatNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tui Neri Emilye Hiriart Patrick P. van Vliet Emilie Faure Russell A. Norris Batoul Farhat Bernd Jagla Julie Lefrancois Yukiko Sugi Thomas Moore-Morris Stéphane Zaffran Randolph S. Faustino Alexander C. Zambon Jean-Pierre Desvignes David Salgado Robert A. Levine Jose Luis de la Pompa André Terzic Sylvia M. Evans Roger Markwald Michel Pucéat Human pre-valvular endocardial cells derived from pluripotent stem cells recapitulate cardiac pathophysiological valvulogenesis
description	There are few human models that can recapitulate valve development in vitro. Here, the authors derive human pre-valvular endocardial cells (HPVCs) from iPSCs and show they can recapitulate early valvulogenesis, and patient derived HPVCs have features of mitral valve prolapse and identified SHH dysregulation.
format	article
author	Tui Neri Emilye Hiriart Patrick P. van Vliet Emilie Faure Russell A. Norris Batoul Farhat Bernd Jagla Julie Lefrancois Yukiko Sugi Thomas Moore-Morris Stéphane Zaffran Randolph S. Faustino Alexander C. Zambon Jean-Pierre Desvignes David Salgado Robert A. Levine Jose Luis de la Pompa André Terzic Sylvia M. Evans Roger Markwald Michel Pucéat
author_facet	Tui Neri Emilye Hiriart Patrick P. van Vliet Emilie Faure Russell A. Norris Batoul Farhat Bernd Jagla Julie Lefrancois Yukiko Sugi Thomas Moore-Morris Stéphane Zaffran Randolph S. Faustino Alexander C. Zambon Jean-Pierre Desvignes David Salgado Robert A. Levine Jose Luis de la Pompa André Terzic Sylvia M. Evans Roger Markwald Michel Pucéat
author_sort	Tui Neri
title	Human pre-valvular endocardial cells derived from pluripotent stem cells recapitulate cardiac pathophysiological valvulogenesis
title_short	Human pre-valvular endocardial cells derived from pluripotent stem cells recapitulate cardiac pathophysiological valvulogenesis
title_full	Human pre-valvular endocardial cells derived from pluripotent stem cells recapitulate cardiac pathophysiological valvulogenesis
title_fullStr	Human pre-valvular endocardial cells derived from pluripotent stem cells recapitulate cardiac pathophysiological valvulogenesis
title_full_unstemmed	Human pre-valvular endocardial cells derived from pluripotent stem cells recapitulate cardiac pathophysiological valvulogenesis
title_sort	human pre-valvular endocardial cells derived from pluripotent stem cells recapitulate cardiac pathophysiological valvulogenesis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/e45f606ce5c6400ca0225b4e0d2ad5be
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Human pre-valvular endocardial cells derived from pluripotent stem cells recapitulate cardiac pathophysiological valvulogenesis

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