Pilot Study Assessing the Impact of Intrathecal Administration of Variants AAV-PHP.B and AAV-PHP.eB on Brain Transduction in Adult Rhesus Macaques

Pilot Study Assessing the Impact of Intrathecal Administration of Variants AAV-PHP.B and AAV-PHP.eB on Brain Transduction in Adult Rhesus Macaques

Adeno-associated virus (AAV) vectors are increasingly used as an effective and safe approach to deliver genetic material to the central nervous system (CNS). The AAV9-derived variants, AAV-PHP. B and AAV-PHP.eB, reportedly broadly transduce cells throughout the CNS compared to the original serotype...

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Bibliographic Details
Main Authors: Marie-Laure Arotcarena, Sandra Dovero, Nathalie Biendon, Nathalie Dutheil, Vincent Planche, Erwan Bezard, Benjamin Dehay
Format: article
Language:EN
Published: Frontiers Media S.A. 2021
Subjects:
adeno-associated virus
intrathecal injection
CNS
non-human primate
animal model
Biotechnology
TP248.13-248.65
Online Access:https://doaj.org/article/e4615ce038d8497193f847e32f41368c
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https://doaj.org/article/e4615ce038d8497193f847e32f41368c

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