Description of a Feline Injection-Site Fibrosarcoma with Metastasis in the Cerebellum

Feline injection-site sarcomas were initially described by Hendrick and Goldschmidt (1991). The link between vaccination site and sarcoma occurrence suggested the term of vaccine-associated sarcomas. Our paper describes an unusual feline injection-site fibrosarcoma with cerebellar metastasis. A 7-ye...

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Autores principales:	Cora Roxana, Gal Adrian Florin, Taulescu Marian, Tăbăran Flaviu, Vidrighinescu Raluca, Cătoi Cornel
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2017
Materias:	cerebellum feline injection-site fi brosarcoma metastasis Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/e46293d19c194ea6b48e4ed6c288fd3a
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spelling	oai:doaj.org-article:e46293d19c194ea6b48e4ed6c288fd3a2021-11-17T21:27:52ZDescription of a Feline Injection-Site Fibrosarcoma with Metastasis in the Cerebellum1820-744810.1515/acve-2017-0047https://doaj.org/article/e46293d19c194ea6b48e4ed6c288fd3a2017-12-01T00:00:00Zhttps://doi.org/10.1515/acve-2017-0047https://doaj.org/toc/1820-7448Feline injection-site sarcomas were initially described by Hendrick and Goldschmidt (1991). The link between vaccination site and sarcoma occurrence suggested the term of vaccine-associated sarcomas. Our paper describes an unusual feline injection-site fibrosarcoma with cerebellar metastasis. A 7-year-old female domestic short-hair cat was submitted to the Pathology Department (Faculty of Veterinary Medicine Cluj- Napoca, Romania) for necropsy. A subcutaneous tumor (relapse) in the interscapular region and multiple metastatic masses in the lungs, kidneys, subcutaneous tissue (scapular and thigh regions) and cerebellum were observed. Cytological, histological and immunohistochemical (for vimentin, desmin, multi-cytokeratin, α-smooth muscle actin, S100 and CD45) analyses from all tumors were performed. Cytological examination identifi ed highly pleomorphic spindle-shaped cells admixed with neoplastic multinucleated giant cells. Histologically, all neoplastic masses were composed of numerous spindle cells arranged into interlacing bundles. Extensive intratumoral areas of necrosis along with a neutrophilic infiltrate were also detected. A fibrillary material was present among neoplastic cells (green stained by Masson’s trichrome method), suggesting a collagenous structure. In all tumors assessed, immunohistochemistry showed an intense reaction only for vimentin in numerous neoplastic cells. Based on the history, gross, cytological, histological and immunohistochemical data, the final diagnosis was recurrent feline injection-site fibrosarcoma, with multiple metastases (including in the cerebellum). Overall, an uncommon case of feline injection-site fibrosarcoma has been reported. This is the first consistent record of an injection site sarcoma in a cat with cerebellar metastasis.Cora RoxanaGal Adrian FlorinTaulescu MarianTăbăran FlaviuVidrighinescu RalucaCătoi CornelSciendoarticlecerebellumfeline injection-site fi brosarcomametastasisVeterinary medicineSF600-1100ENActa Veterinaria, Vol 67, Iss 4, Pp 578-586 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	cerebellum feline injection-site fi brosarcoma metastasis Veterinary medicine SF600-1100
spellingShingle	cerebellum feline injection-site fi brosarcoma metastasis Veterinary medicine SF600-1100 Cora Roxana Gal Adrian Florin Taulescu Marian Tăbăran Flaviu Vidrighinescu Raluca Cătoi Cornel Description of a Feline Injection-Site Fibrosarcoma with Metastasis in the Cerebellum
description	Feline injection-site sarcomas were initially described by Hendrick and Goldschmidt (1991). The link between vaccination site and sarcoma occurrence suggested the term of vaccine-associated sarcomas. Our paper describes an unusual feline injection-site fibrosarcoma with cerebellar metastasis. A 7-year-old female domestic short-hair cat was submitted to the Pathology Department (Faculty of Veterinary Medicine Cluj- Napoca, Romania) for necropsy. A subcutaneous tumor (relapse) in the interscapular region and multiple metastatic masses in the lungs, kidneys, subcutaneous tissue (scapular and thigh regions) and cerebellum were observed. Cytological, histological and immunohistochemical (for vimentin, desmin, multi-cytokeratin, α-smooth muscle actin, S100 and CD45) analyses from all tumors were performed. Cytological examination identifi ed highly pleomorphic spindle-shaped cells admixed with neoplastic multinucleated giant cells. Histologically, all neoplastic masses were composed of numerous spindle cells arranged into interlacing bundles. Extensive intratumoral areas of necrosis along with a neutrophilic infiltrate were also detected. A fibrillary material was present among neoplastic cells (green stained by Masson’s trichrome method), suggesting a collagenous structure. In all tumors assessed, immunohistochemistry showed an intense reaction only for vimentin in numerous neoplastic cells. Based on the history, gross, cytological, histological and immunohistochemical data, the final diagnosis was recurrent feline injection-site fibrosarcoma, with multiple metastases (including in the cerebellum). Overall, an uncommon case of feline injection-site fibrosarcoma has been reported. This is the first consistent record of an injection site sarcoma in a cat with cerebellar metastasis.
format	article
author	Cora Roxana Gal Adrian Florin Taulescu Marian Tăbăran Flaviu Vidrighinescu Raluca Cătoi Cornel
author_facet	Cora Roxana Gal Adrian Florin Taulescu Marian Tăbăran Flaviu Vidrighinescu Raluca Cătoi Cornel
author_sort	Cora Roxana
title	Description of a Feline Injection-Site Fibrosarcoma with Metastasis in the Cerebellum
title_short	Description of a Feline Injection-Site Fibrosarcoma with Metastasis in the Cerebellum
title_full	Description of a Feline Injection-Site Fibrosarcoma with Metastasis in the Cerebellum
title_fullStr	Description of a Feline Injection-Site Fibrosarcoma with Metastasis in the Cerebellum
title_full_unstemmed	Description of a Feline Injection-Site Fibrosarcoma with Metastasis in the Cerebellum
title_sort	description of a feline injection-site fibrosarcoma with metastasis in the cerebellum
publisher	Sciendo
publishDate	2017
url	https://doaj.org/article/e46293d19c194ea6b48e4ed6c288fd3a
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Description of a Feline Injection-Site Fibrosarcoma with Metastasis in the Cerebellum

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