DIAGNOSTIC ACCURACY OF TYPHIDOT IN PATIENTS OF TYPHOID FEVER

Objective: To assess the diagnostic accuracy of Typhidot test in patients with acute febrile illness taking blood culture as gold standard. Study Design: Cross-sectional validation study. Place and Duration of Study: The study was conducted at Combined Military Hospital Kohat, from Mar 2016 to O...

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Autores principales:	Hammad Javed, Karamat Hussain, Tariq Bashir, Sana ullah, Umair Ijaz, Ismail Khoso
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2018
Materias:	blood culture diagnostic accuracy typhidot Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/e463dc7c13c44bfd8019409812a8ff50
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spelling	oai:doaj.org-article:e463dc7c13c44bfd8019409812a8ff502021-12-02T03:52:40ZDIAGNOSTIC ACCURACY OF TYPHIDOT IN PATIENTS OF TYPHOID FEVER0030-96482411-8842https://doaj.org/article/e463dc7c13c44bfd8019409812a8ff502018-10-01T00:00:00Zhttps://www.pafmj.org/index.php/PAFMJ/article/view/2295/1990https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To assess the diagnostic accuracy of Typhidot test in patients with acute febrile illness taking blood culture as gold standard. Study Design: Cross-sectional validation study. Place and Duration of Study: The study was conducted at Combined Military Hospital Kohat, from Mar 2016 to Oct 2016. Material and Methods: In this study 211 patients with acute febrile illness were included. All patients had Typhidot IgM test done along with blood cultures, blood counts, chemistries and relevant diagnostic tests. Patients were divided into two groups based on blood culture results and both groups were compared in terms of positivity for Typhidot. Sensitivity, specificity, positive predictive value and negative predictive value were calculated using SPSS v 20. Chi square was applied to assess the association between Typhidot and blood culture results. Results: Out of total 211patients, 49 patients had typhoid fever (culture positive) and 162 had non-typhoidal illnesses (culture negative). Typhidot IgM was positive in 47 (95.9%) cases of typhoid fever and in 155 (73.5%) cases of non-typhoidal fevers. The sensitivity of Typhidot for diagnosis of typhoid fever was 95.9% and specificity was 26.5%. Conclusion: Our study reveals that Typhidot IgM has high sensitivity for typhoid fever but specificity and diagnostic accuracy are very low. Nevertheless, a high negative predictive value means it can help rule out the disease in suspected cases.Hammad JavedKaramat HussainTariq BashirSana ullahUmair IjazIsmail KhosoArmy Medical College Rawalpindiarticleblood culturediagnostic accuracytyphidotMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 68, Iss 5, Pp 1215-1218 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	blood culture diagnostic accuracy typhidot Medicine R Medicine (General) R5-920
spellingShingle	blood culture diagnostic accuracy typhidot Medicine R Medicine (General) R5-920 Hammad Javed Karamat Hussain Tariq Bashir Sana ullah Umair Ijaz Ismail Khoso DIAGNOSTIC ACCURACY OF TYPHIDOT IN PATIENTS OF TYPHOID FEVER
description	Objective: To assess the diagnostic accuracy of Typhidot test in patients with acute febrile illness taking blood culture as gold standard. Study Design: Cross-sectional validation study. Place and Duration of Study: The study was conducted at Combined Military Hospital Kohat, from Mar 2016 to Oct 2016. Material and Methods: In this study 211 patients with acute febrile illness were included. All patients had Typhidot IgM test done along with blood cultures, blood counts, chemistries and relevant diagnostic tests. Patients were divided into two groups based on blood culture results and both groups were compared in terms of positivity for Typhidot. Sensitivity, specificity, positive predictive value and negative predictive value were calculated using SPSS v 20. Chi square was applied to assess the association between Typhidot and blood culture results. Results: Out of total 211patients, 49 patients had typhoid fever (culture positive) and 162 had non-typhoidal illnesses (culture negative). Typhidot IgM was positive in 47 (95.9%) cases of typhoid fever and in 155 (73.5%) cases of non-typhoidal fevers. The sensitivity of Typhidot for diagnosis of typhoid fever was 95.9% and specificity was 26.5%. Conclusion: Our study reveals that Typhidot IgM has high sensitivity for typhoid fever but specificity and diagnostic accuracy are very low. Nevertheless, a high negative predictive value means it can help rule out the disease in suspected cases.
format	article
author	Hammad Javed Karamat Hussain Tariq Bashir Sana ullah Umair Ijaz Ismail Khoso
author_facet	Hammad Javed Karamat Hussain Tariq Bashir Sana ullah Umair Ijaz Ismail Khoso
author_sort	Hammad Javed
title	DIAGNOSTIC ACCURACY OF TYPHIDOT IN PATIENTS OF TYPHOID FEVER
title_short	DIAGNOSTIC ACCURACY OF TYPHIDOT IN PATIENTS OF TYPHOID FEVER
title_full	DIAGNOSTIC ACCURACY OF TYPHIDOT IN PATIENTS OF TYPHOID FEVER
title_fullStr	DIAGNOSTIC ACCURACY OF TYPHIDOT IN PATIENTS OF TYPHOID FEVER
title_full_unstemmed	DIAGNOSTIC ACCURACY OF TYPHIDOT IN PATIENTS OF TYPHOID FEVER
title_sort	diagnostic accuracy of typhidot in patients of typhoid fever
publisher	Army Medical College Rawalpindi
publishDate	2018
url	https://doaj.org/article/e463dc7c13c44bfd8019409812a8ff50
work_keys_str_mv	AT hammadjaved diagnosticaccuracyoftyphidotinpatientsoftyphoidfever AT karamathussain diagnosticaccuracyoftyphidotinpatientsoftyphoidfever AT tariqbashir diagnosticaccuracyoftyphidotinpatientsoftyphoidfever AT sanaullah diagnosticaccuracyoftyphidotinpatientsoftyphoidfever AT umairijaz diagnosticaccuracyoftyphidotinpatientsoftyphoidfever AT ismailkhoso diagnosticaccuracyoftyphidotinpatientsoftyphoidfever
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DIAGNOSTIC ACCURACY OF TYPHIDOT IN PATIENTS OF TYPHOID FEVER

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