Intratracheal instillation of cerium oxide nanoparticles induces hepatic toxicity in male Sprague-Dawley rats

Siva K Nalabotu1,2, Madhukar B Kolli1,2, William E Triest3,4, Jane Y Ma5, Nandini DPK Manne2,6, Anjaiah Katta1,2, Hari S Addagarla2, Kevin M Rice2,6&ndash;8, Eric R Blough1,2,6,7,91Department of Pharmacology, Physiology and Toxicology, Marshall University, Joan C Edwards School of Medicine;...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Nalabotu SK, Kolli MB, Triest WE, Ma JY, Manne NDPK, Katta A, Addagarla HS, Rice KM, Blough ER
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/e4658ff469e842d0b4ba14cbfa7230c9
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e4658ff469e842d0b4ba14cbfa7230c9
record_format	dspace
spelling	oai:doaj.org-article:e4658ff469e842d0b4ba14cbfa7230c92021-12-02T07:11:23ZIntratracheal instillation of cerium oxide nanoparticles induces hepatic toxicity in male Sprague-Dawley rats1176-91141178-2013https://doaj.org/article/e4658ff469e842d0b4ba14cbfa7230c92011-10-01T00:00:00Zhttp://www.dovepress.com/intratracheal-instillation-of-cerium-oxide-nanoparticles-induces-hepat-a8471https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Siva K Nalabotu1,2, Madhukar B Kolli1,2, William E Triest3,4, Jane Y Ma5, Nandini DPK Manne2,6, Anjaiah Katta1,2, Hari S Addagarla2, Kevin M Rice2,6&ndash;8, Eric R Blough1,2,6,7,91Department of Pharmacology, Physiology and Toxicology, Marshall University, Joan C Edwards School of Medicine; 2Center for Diagnostic Nanosystems, Marshall University; 3Pathology and Laboratory Medicine Service, Veterans Affairs Medical Center; 4Section of Pathology, Department of Anatomy and Pathology, Joan C Edwards School of Medicine, Marshall University, Huntington; 5Health Effects Laboratory Division, NIOSH, Morgantown; 6Department of Biological Sciences; 7School of Kinesiology, College of Health Professions, Marshall University; 8Biotechnology Department, West Virginia State University; 9Department of Cardiology, Joan C Edwards School of Medicine, Marshall University Huntington, WV, USABackground: Cerium oxide (CeO2) nanoparticles have been posited to have both beneficial and toxic effects on biological systems. Herein, we examine if a single intratracheal instillation of CeO2 nanoparticles is associated with systemic toxicity in male Sprague-Dawley rats.Methods and results: Compared with control animals, CeO2 nanoparticle exposure was associated with increased liver ceria levels, elevations in serum alanine transaminase levels, reduced albumin levels, a diminished sodium-potassium ratio, and decreased serum triglyceride levels (P &lt; 0.05). Consistent with these data, rats exposed to CeO2 nanoparticles also exhibited reductions in liver weight (P &lt; 0.05) and dose-dependent hydropic degeneration, hepatocyte enlargement, sinusoidal dilatation, and accumulation of granular material. No histopathological alterations were observed in the kidney, spleen, and heart. Analysis of serum biomarkers suggested an elevation of acute phase reactants and markers of hepatocyte injury in the rats exposed to CeO2 nanoparticles.Conclusion: Taken together, these data suggest that intratracheal instillation of CeO2 nanoparticles can result in liver damage.Keywords: cerium oxide nanoparticles, systemic toxicity, hepatic toxicity, hydropic degenerationNalabotu SKKolli MBTriest WEMa JYManne NDPKKatta AAddagarla HSRice KMBlough ERDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2011, Iss default, Pp 2327-2335 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Nalabotu SK Kolli MB Triest WE Ma JY Manne NDPK Katta A Addagarla HS Rice KM Blough ER Intratracheal instillation of cerium oxide nanoparticles induces hepatic toxicity in male Sprague-Dawley rats
description	Siva K Nalabotu1,2, Madhukar B Kolli1,2, William E Triest3,4, Jane Y Ma5, Nandini DPK Manne2,6, Anjaiah Katta1,2, Hari S Addagarla2, Kevin M Rice2,6&ndash;8, Eric R Blough1,2,6,7,91Department of Pharmacology, Physiology and Toxicology, Marshall University, Joan C Edwards School of Medicine; 2Center for Diagnostic Nanosystems, Marshall University; 3Pathology and Laboratory Medicine Service, Veterans Affairs Medical Center; 4Section of Pathology, Department of Anatomy and Pathology, Joan C Edwards School of Medicine, Marshall University, Huntington; 5Health Effects Laboratory Division, NIOSH, Morgantown; 6Department of Biological Sciences; 7School of Kinesiology, College of Health Professions, Marshall University; 8Biotechnology Department, West Virginia State University; 9Department of Cardiology, Joan C Edwards School of Medicine, Marshall University Huntington, WV, USABackground: Cerium oxide (CeO2) nanoparticles have been posited to have both beneficial and toxic effects on biological systems. Herein, we examine if a single intratracheal instillation of CeO2 nanoparticles is associated with systemic toxicity in male Sprague-Dawley rats.Methods and results: Compared with control animals, CeO2 nanoparticle exposure was associated with increased liver ceria levels, elevations in serum alanine transaminase levels, reduced albumin levels, a diminished sodium-potassium ratio, and decreased serum triglyceride levels (P &lt; 0.05). Consistent with these data, rats exposed to CeO2 nanoparticles also exhibited reductions in liver weight (P &lt; 0.05) and dose-dependent hydropic degeneration, hepatocyte enlargement, sinusoidal dilatation, and accumulation of granular material. No histopathological alterations were observed in the kidney, spleen, and heart. Analysis of serum biomarkers suggested an elevation of acute phase reactants and markers of hepatocyte injury in the rats exposed to CeO2 nanoparticles.Conclusion: Taken together, these data suggest that intratracheal instillation of CeO2 nanoparticles can result in liver damage.Keywords: cerium oxide nanoparticles, systemic toxicity, hepatic toxicity, hydropic degeneration
format	article
author	Nalabotu SK Kolli MB Triest WE Ma JY Manne NDPK Katta A Addagarla HS Rice KM Blough ER
author_facet	Nalabotu SK Kolli MB Triest WE Ma JY Manne NDPK Katta A Addagarla HS Rice KM Blough ER
author_sort	Nalabotu SK
title	Intratracheal instillation of cerium oxide nanoparticles induces hepatic toxicity in male Sprague-Dawley rats
title_short	Intratracheal instillation of cerium oxide nanoparticles induces hepatic toxicity in male Sprague-Dawley rats
title_full	Intratracheal instillation of cerium oxide nanoparticles induces hepatic toxicity in male Sprague-Dawley rats
title_fullStr	Intratracheal instillation of cerium oxide nanoparticles induces hepatic toxicity in male Sprague-Dawley rats
title_full_unstemmed	Intratracheal instillation of cerium oxide nanoparticles induces hepatic toxicity in male Sprague-Dawley rats
title_sort	intratracheal instillation of cerium oxide nanoparticles induces hepatic toxicity in male sprague-dawley rats
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/e4658ff469e842d0b4ba14cbfa7230c9
work_keys_str_mv	AT nalabotusk intratrachealinstillationofceriumoxidenanoparticlesinduceshepatictoxicityinmalespraguedawleyrats AT kollimb intratrachealinstillationofceriumoxidenanoparticlesinduceshepatictoxicityinmalespraguedawleyrats AT triestwe intratrachealinstillationofceriumoxidenanoparticlesinduceshepatictoxicityinmalespraguedawleyrats AT majy intratrachealinstillationofceriumoxidenanoparticlesinduceshepatictoxicityinmalespraguedawleyrats AT mannendpk intratrachealinstillationofceriumoxidenanoparticlesinduceshepatictoxicityinmalespraguedawleyrats AT kattaa intratrachealinstillationofceriumoxidenanoparticlesinduceshepatictoxicityinmalespraguedawleyrats AT addagarlahs intratrachealinstillationofceriumoxidenanoparticlesinduceshepatictoxicityinmalespraguedawleyrats AT ricekm intratrachealinstillationofceriumoxidenanoparticlesinduceshepatictoxicityinmalespraguedawleyrats AT blougher intratrachealinstillationofceriumoxidenanoparticlesinduceshepatictoxicityinmalespraguedawleyrats
_version_	1718399608071127040

Intratracheal instillation of cerium oxide nanoparticles induces hepatic toxicity in male Sprague-Dawley rats

Ejemplares similares