Point mutations in FimH adhesin of Crohn's disease-associated adherent-invasive Escherichia coli enhance intestinal inflammatory response.

Point mutations in FimH adhesin of Crohn's disease-associated adherent-invasive Escherichia coli enhance intestinal inflammatory response.

Adherent-invasive Escherichia coli (AIEC) are abnormally predominant on Crohn's disease (CD) ileal mucosa. AIEC reference strain LF82 adheres to ileal enterocytes via the common type 1 pili adhesin FimH and recognizes CEACAM6 receptors abnormally expressed on CD ileal epithelial cells. The fimH...

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Auteurs principaux: Nicolas Dreux, Jérémy Denizot, Margarita Martinez-Medina, Alexander Mellmann, Maria Billig, Dagmara Kisiela, Sujay Chattopadhyay, Evgeni Sokurenko, Christel Neut, Corinne Gower-Rousseau, Jean-Frédéric Colombel, Richard Bonnet, Arlette Darfeuille-Michaud, Nicolas Barnich
Format: article
Langue:EN
Publié: Public Library of Science (PLoS) 2013
Sujets:
Immunologic diseases. Allergy
RC581-607
Biology (General)
QH301-705.5
Accès en ligne:https://doaj.org/article/e4669ff6ea7c4a89b4023b6ba16045c3
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Internet

https://doaj.org/article/e4669ff6ea7c4a89b4023b6ba16045c3

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