Two distinct chronic obstructive pulmonary disease (COPD) phenotypes are associated with high risk of mortality.

<h4>Rationale</h4>In COPD patients, mortality risk is influenced by age, severity of respiratory disease, and comorbidities. With an unbiased statistical approach we sought to identify clusters of COPD patients and to examine their mortality risk.<h4>Methods</h4>Stable COPD s...

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Autores principales:	Pierre-Régis Burgel, Jean-Louis Paillasseur, Bernard Peene, Daniel Dusser, Nicolas Roche, Johan Coolen, Thierry Troosters, Marc Decramer, Wim Janssens
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e46856e48e8240e289f8c602d6f17522
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spelling	oai:doaj.org-article:e46856e48e8240e289f8c602d6f175222021-11-18T08:06:00ZTwo distinct chronic obstructive pulmonary disease (COPD) phenotypes are associated with high risk of mortality.1932-620310.1371/journal.pone.0051048https://doaj.org/article/e46856e48e8240e289f8c602d6f175222012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23236428/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Rationale</h4>In COPD patients, mortality risk is influenced by age, severity of respiratory disease, and comorbidities. With an unbiased statistical approach we sought to identify clusters of COPD patients and to examine their mortality risk.<h4>Methods</h4>Stable COPD subjects (n = 527) were classified using hierarchical cluster analysis of clinical, functional and imaging data. The relevance of this classification was validated using prospective follow-up of mortality.<h4>Results</h4>The most relevant patient classification was that based on three clusters (phenotypes). Phenotype 1 included subjects at very low risk of mortality, who had mild respiratory disease and low rates of comorbidities. Phenotype 2 and 3 were at high risk of mortality. Phenotype 2 included younger subjects with severe airflow limitation, emphysema and hyperinflation, low body mass index, and low rates of cardiovascular comorbidities. Phenotype 3 included older subjects with less severe respiratory disease, but higher rates of obesity and cardiovascular comorbidities. Mortality was associated with the severity of airflow limitation in Phenotype 2 but not in Phenotype 3 subjects, and subjects in Phenotype 2 died at younger age.<h4>Conclusions</h4>We identified three COPD phenotypes, including two phenotypes with high risk of mortality. Subjects within these phenotypes may require different therapeutic interventions to improve their outcome.Pierre-Régis BurgelJean-Louis PaillasseurBernard PeeneDaniel DusserNicolas RocheJohan CoolenThierry TroostersMarc DecramerWim JanssensPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 12, p e51048 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Pierre-Régis Burgel Jean-Louis Paillasseur Bernard Peene Daniel Dusser Nicolas Roche Johan Coolen Thierry Troosters Marc Decramer Wim Janssens Two distinct chronic obstructive pulmonary disease (COPD) phenotypes are associated with high risk of mortality.
description	<h4>Rationale</h4>In COPD patients, mortality risk is influenced by age, severity of respiratory disease, and comorbidities. With an unbiased statistical approach we sought to identify clusters of COPD patients and to examine their mortality risk.<h4>Methods</h4>Stable COPD subjects (n = 527) were classified using hierarchical cluster analysis of clinical, functional and imaging data. The relevance of this classification was validated using prospective follow-up of mortality.<h4>Results</h4>The most relevant patient classification was that based on three clusters (phenotypes). Phenotype 1 included subjects at very low risk of mortality, who had mild respiratory disease and low rates of comorbidities. Phenotype 2 and 3 were at high risk of mortality. Phenotype 2 included younger subjects with severe airflow limitation, emphysema and hyperinflation, low body mass index, and low rates of cardiovascular comorbidities. Phenotype 3 included older subjects with less severe respiratory disease, but higher rates of obesity and cardiovascular comorbidities. Mortality was associated with the severity of airflow limitation in Phenotype 2 but not in Phenotype 3 subjects, and subjects in Phenotype 2 died at younger age.<h4>Conclusions</h4>We identified three COPD phenotypes, including two phenotypes with high risk of mortality. Subjects within these phenotypes may require different therapeutic interventions to improve their outcome.
format	article
author	Pierre-Régis Burgel Jean-Louis Paillasseur Bernard Peene Daniel Dusser Nicolas Roche Johan Coolen Thierry Troosters Marc Decramer Wim Janssens
author_facet	Pierre-Régis Burgel Jean-Louis Paillasseur Bernard Peene Daniel Dusser Nicolas Roche Johan Coolen Thierry Troosters Marc Decramer Wim Janssens
author_sort	Pierre-Régis Burgel
title	Two distinct chronic obstructive pulmonary disease (COPD) phenotypes are associated with high risk of mortality.
title_short	Two distinct chronic obstructive pulmonary disease (COPD) phenotypes are associated with high risk of mortality.
title_full	Two distinct chronic obstructive pulmonary disease (COPD) phenotypes are associated with high risk of mortality.
title_fullStr	Two distinct chronic obstructive pulmonary disease (COPD) phenotypes are associated with high risk of mortality.
title_full_unstemmed	Two distinct chronic obstructive pulmonary disease (COPD) phenotypes are associated with high risk of mortality.
title_sort	two distinct chronic obstructive pulmonary disease (copd) phenotypes are associated with high risk of mortality.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/e46856e48e8240e289f8c602d6f17522
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Two distinct chronic obstructive pulmonary disease (COPD) phenotypes are associated with high risk of mortality.

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