Targeting photodynamic and photothermal therapy to the endoplasmic reticulum enhances immunogenic cancer cell death

Reactive oxygen species induced by endoplasmic reitculum stress can be exploited for cancer therapy. Here, nanoparticles are targetted to the endoplasmic reticulum and, when accompanied by PDT, produce stress resulting in calreticulin exposure on the cell surface, which activates dendritic cells.

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Auteurs principaux:	Wei Li, Jie Yang, Lihua Luo, Mengshi Jiang, Bing Qin, Hang Yin, Chunqi Zhu, Xiaoling Yuan, Junlei Zhang, Zhenyu Luo, Yongzhong Du, Qingpo Li, Yan Lou, Yunqing Qiu, Jian You
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2019
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/e46aba4516854b02945a88bde7ff8b77
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spelling	oai:doaj.org-article:e46aba4516854b02945a88bde7ff8b772021-12-02T14:38:37ZTargeting photodynamic and photothermal therapy to the endoplasmic reticulum enhances immunogenic cancer cell death10.1038/s41467-019-11269-82041-1723https://doaj.org/article/e46aba4516854b02945a88bde7ff8b772019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11269-8https://doaj.org/toc/2041-1723Reactive oxygen species induced by endoplasmic reitculum stress can be exploited for cancer therapy. Here, nanoparticles are targetted to the endoplasmic reticulum and, when accompanied by PDT, produce stress resulting in calreticulin exposure on the cell surface, which activates dendritic cells.Wei LiJie YangLihua LuoMengshi JiangBing QinHang YinChunqi ZhuXiaoling YuanJunlei ZhangZhenyu LuoYongzhong DuQingpo LiYan LouYunqing QiuJian YouNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wei Li Jie Yang Lihua Luo Mengshi Jiang Bing Qin Hang Yin Chunqi Zhu Xiaoling Yuan Junlei Zhang Zhenyu Luo Yongzhong Du Qingpo Li Yan Lou Yunqing Qiu Jian You Targeting photodynamic and photothermal therapy to the endoplasmic reticulum enhances immunogenic cancer cell death
description	Reactive oxygen species induced by endoplasmic reitculum stress can be exploited for cancer therapy. Here, nanoparticles are targetted to the endoplasmic reticulum and, when accompanied by PDT, produce stress resulting in calreticulin exposure on the cell surface, which activates dendritic cells.
format	article
author	Wei Li Jie Yang Lihua Luo Mengshi Jiang Bing Qin Hang Yin Chunqi Zhu Xiaoling Yuan Junlei Zhang Zhenyu Luo Yongzhong Du Qingpo Li Yan Lou Yunqing Qiu Jian You
author_facet	Wei Li Jie Yang Lihua Luo Mengshi Jiang Bing Qin Hang Yin Chunqi Zhu Xiaoling Yuan Junlei Zhang Zhenyu Luo Yongzhong Du Qingpo Li Yan Lou Yunqing Qiu Jian You
author_sort	Wei Li
title	Targeting photodynamic and photothermal therapy to the endoplasmic reticulum enhances immunogenic cancer cell death
title_short	Targeting photodynamic and photothermal therapy to the endoplasmic reticulum enhances immunogenic cancer cell death
title_full	Targeting photodynamic and photothermal therapy to the endoplasmic reticulum enhances immunogenic cancer cell death
title_fullStr	Targeting photodynamic and photothermal therapy to the endoplasmic reticulum enhances immunogenic cancer cell death
title_full_unstemmed	Targeting photodynamic and photothermal therapy to the endoplasmic reticulum enhances immunogenic cancer cell death
title_sort	targeting photodynamic and photothermal therapy to the endoplasmic reticulum enhances immunogenic cancer cell death
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/e46aba4516854b02945a88bde7ff8b77
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Targeting photodynamic and photothermal therapy to the endoplasmic reticulum enhances immunogenic cancer cell death

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