Increased adipose tissue heme levels and exportation are associated with altered systemic glucose metabolism

Abstract Iron status is known to be associated with the physiology of adipose tissue (AT). We aimed to investigate AT heme and expression of heme exporter (FLVCR1) in association with obesity and type 2 diabetes (T2D). Substantial amounts of FLVCR1 mRNA and protein levels were detected in AT, being...

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Autores principales:	José María Moreno-Navarrete, Amaia Rodríguez, Francisco Ortega, Sara Becerril, Mònica Sabater-Masdeu, Jessica Latorre, Wifredo Ricart, Gema Frühbeck, José Manuel Fernández-Real
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e46d89855e2748d69d10d87f6683d7c9
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spelling	oai:doaj.org-article:e46d89855e2748d69d10d87f6683d7c92021-12-02T15:06:21ZIncreased adipose tissue heme levels and exportation are associated with altered systemic glucose metabolism10.1038/s41598-017-05597-22045-2322https://doaj.org/article/e46d89855e2748d69d10d87f6683d7c92017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05597-2https://doaj.org/toc/2045-2322Abstract Iron status is known to be associated with the physiology of adipose tissue (AT). We aimed to investigate AT heme and expression of heme exporter (FLVCR1) in association with obesity and type 2 diabetes (T2D). Substantial amounts of FLVCR1 mRNA and protein levels were detected in AT, being significantly increased in subjects with T2D, and positively correlated with fasting glucose, fasting triglycerides and with circulating markers of iron stores (serum ferritin, blood hemoglobin and hematocrit). In both visceral (VAT) and subcutaneous AT (SAT), increased heme levels were found in subjects with T2D. Reinforcing these associations, FLVCR1 mRNA levels were positively linked to fasting glucose in an independent cohort. Longitudianlly, the percent change of FLVCR1 positively correlated with the percent change in fasting glucose (r = 0.52, p = 0.03) after bariatric surgery-induced weight loss. High-fat diet-induced weight gain in rats did not result in significant changes in AT Flvcr1 mRNA but, remarkably, the expression of this gene positively correlated with fasting glucose and negatively with insulin sensitivity (QUICKI). Altogether, these findings showed a direct association between FLVCR1 mRNA levels and hyperglycemia, suggesting that increased adipose tissue heme exportation might disrupt, or is the consequence of, impaired systemic glucose metabolism during the progression to T2D.José María Moreno-NavarreteAmaia RodríguezFrancisco OrtegaSara BecerrilMònica Sabater-MasdeuJessica LatorreWifredo RicartGema FrühbeckJosé Manuel Fernández-RealNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q José María Moreno-Navarrete Amaia Rodríguez Francisco Ortega Sara Becerril Mònica Sabater-Masdeu Jessica Latorre Wifredo Ricart Gema Frühbeck José Manuel Fernández-Real Increased adipose tissue heme levels and exportation are associated with altered systemic glucose metabolism
description	Abstract Iron status is known to be associated with the physiology of adipose tissue (AT). We aimed to investigate AT heme and expression of heme exporter (FLVCR1) in association with obesity and type 2 diabetes (T2D). Substantial amounts of FLVCR1 mRNA and protein levels were detected in AT, being significantly increased in subjects with T2D, and positively correlated with fasting glucose, fasting triglycerides and with circulating markers of iron stores (serum ferritin, blood hemoglobin and hematocrit). In both visceral (VAT) and subcutaneous AT (SAT), increased heme levels were found in subjects with T2D. Reinforcing these associations, FLVCR1 mRNA levels were positively linked to fasting glucose in an independent cohort. Longitudianlly, the percent change of FLVCR1 positively correlated with the percent change in fasting glucose (r = 0.52, p = 0.03) after bariatric surgery-induced weight loss. High-fat diet-induced weight gain in rats did not result in significant changes in AT Flvcr1 mRNA but, remarkably, the expression of this gene positively correlated with fasting glucose and negatively with insulin sensitivity (QUICKI). Altogether, these findings showed a direct association between FLVCR1 mRNA levels and hyperglycemia, suggesting that increased adipose tissue heme exportation might disrupt, or is the consequence of, impaired systemic glucose metabolism during the progression to T2D.
format	article
author	José María Moreno-Navarrete Amaia Rodríguez Francisco Ortega Sara Becerril Mònica Sabater-Masdeu Jessica Latorre Wifredo Ricart Gema Frühbeck José Manuel Fernández-Real
author_facet	José María Moreno-Navarrete Amaia Rodríguez Francisco Ortega Sara Becerril Mònica Sabater-Masdeu Jessica Latorre Wifredo Ricart Gema Frühbeck José Manuel Fernández-Real
author_sort	José María Moreno-Navarrete
title	Increased adipose tissue heme levels and exportation are associated with altered systemic glucose metabolism
title_short	Increased adipose tissue heme levels and exportation are associated with altered systemic glucose metabolism
title_full	Increased adipose tissue heme levels and exportation are associated with altered systemic glucose metabolism
title_fullStr	Increased adipose tissue heme levels and exportation are associated with altered systemic glucose metabolism
title_full_unstemmed	Increased adipose tissue heme levels and exportation are associated with altered systemic glucose metabolism
title_sort	increased adipose tissue heme levels and exportation are associated with altered systemic glucose metabolism
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e46d89855e2748d69d10d87f6683d7c9
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Increased adipose tissue heme levels and exportation are associated with altered systemic glucose metabolism

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