Scaffold-free cell-based tissue engineering therapies: advances, shortfalls and forecast

Abstract Cell-based scaffold-free therapies seek to develop in vitro organotypic three-dimensional (3D) tissue-like surrogates, capitalising upon the inherent capacity of cells to create tissues with efficiency and sophistication that is still unparalleled by human-made devices. Although automation...

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Autores principales:	Andrea De Pieri, Yury Rochev, Dimitrios I. Zeugolis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R
Acceso en línea:	https://doaj.org/article/e46f1ce01c0b41439ae9e3cc22956c3e
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spelling	oai:doaj.org-article:e46f1ce01c0b41439ae9e3cc22956c3e2021-12-02T14:23:17ZScaffold-free cell-based tissue engineering therapies: advances, shortfalls and forecast10.1038/s41536-021-00133-32057-3995https://doaj.org/article/e46f1ce01c0b41439ae9e3cc22956c3e2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41536-021-00133-3https://doaj.org/toc/2057-3995Abstract Cell-based scaffold-free therapies seek to develop in vitro organotypic three-dimensional (3D) tissue-like surrogates, capitalising upon the inherent capacity of cells to create tissues with efficiency and sophistication that is still unparalleled by human-made devices. Although automation systems have been realised and (some) success stories have been witnessed over the years in clinical and commercial arenas, in vitro organogenesis is far from becoming a standard way of care. This limited technology transfer is largely attributed to scalability-associated costs, considering that the development of a borderline 3D implantable device requires very high number of functional cells and prolonged ex vivo culture periods. Herein, we critically discuss advancements and shortfalls of scaffold-free cell-based tissue engineering strategies, along with pioneering concepts that have the potential to transform regenerative and reparative medicine.Andrea De PieriYury RochevDimitrios I. ZeugolisNature PortfolioarticleMedicineRENnpj Regenerative Medicine, Vol 6, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R
spellingShingle	Medicine R Andrea De Pieri Yury Rochev Dimitrios I. Zeugolis Scaffold-free cell-based tissue engineering therapies: advances, shortfalls and forecast
description	Abstract Cell-based scaffold-free therapies seek to develop in vitro organotypic three-dimensional (3D) tissue-like surrogates, capitalising upon the inherent capacity of cells to create tissues with efficiency and sophistication that is still unparalleled by human-made devices. Although automation systems have been realised and (some) success stories have been witnessed over the years in clinical and commercial arenas, in vitro organogenesis is far from becoming a standard way of care. This limited technology transfer is largely attributed to scalability-associated costs, considering that the development of a borderline 3D implantable device requires very high number of functional cells and prolonged ex vivo culture periods. Herein, we critically discuss advancements and shortfalls of scaffold-free cell-based tissue engineering strategies, along with pioneering concepts that have the potential to transform regenerative and reparative medicine.
format	article
author	Andrea De Pieri Yury Rochev Dimitrios I. Zeugolis
author_facet	Andrea De Pieri Yury Rochev Dimitrios I. Zeugolis
author_sort	Andrea De Pieri
title	Scaffold-free cell-based tissue engineering therapies: advances, shortfalls and forecast
title_short	Scaffold-free cell-based tissue engineering therapies: advances, shortfalls and forecast
title_full	Scaffold-free cell-based tissue engineering therapies: advances, shortfalls and forecast
title_fullStr	Scaffold-free cell-based tissue engineering therapies: advances, shortfalls and forecast
title_full_unstemmed	Scaffold-free cell-based tissue engineering therapies: advances, shortfalls and forecast
title_sort	scaffold-free cell-based tissue engineering therapies: advances, shortfalls and forecast
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e46f1ce01c0b41439ae9e3cc22956c3e
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Scaffold-free cell-based tissue engineering therapies: advances, shortfalls and forecast

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