Antiviral activity of ethanol extract of Geranii Herba and its components against influenza viruses via neuraminidase inhibition

Abstract Influenza viruses are a serious threat to human health, causing numerous deaths and pandemics worldwide. To date, neuraminidase (NA) inhibitors have primarily been used to treat influenza. However, there is a growing need for novel NA inhibitors owing to the emergence of resistant viruses....

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Autores principales:	Jang-Gi Choi, Young Soo Kim, Ji Hye Kim, Hwan-Suck Chung
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e470483ac082453fb2772cfc872135db
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spelling	oai:doaj.org-article:e470483ac082453fb2772cfc872135db2021-12-02T15:08:47ZAntiviral activity of ethanol extract of Geranii Herba and its components against influenza viruses via neuraminidase inhibition10.1038/s41598-019-48430-82045-2322https://doaj.org/article/e470483ac082453fb2772cfc872135db2019-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-48430-8https://doaj.org/toc/2045-2322Abstract Influenza viruses are a serious threat to human health, causing numerous deaths and pandemics worldwide. To date, neuraminidase (NA) inhibitors have primarily been used to treat influenza. However, there is a growing need for novel NA inhibitors owing to the emergence of resistant viruses. Geranii Herba (Geranium thunbergii Siebold et Zuccarini), which is edible, has long been used in a variety of disease treatments in Asia. Although recent studies have reported its various pharmacological activities, the effect of Geranii Herba and its components on influenza viruses has not yet been reported. In this study, Geranii Herba ethanol extract (GHE) and its component geraniin showed high antiviral activity against influenza A strain as well as influenza B strain, against which oseltamivir has less efficacy than influenza A strain, by inhibiting NA activity following viral infection in Madin–Darby canine kidney cells. Thus, GHE and its components may be useful for the development of anti-influenza drugs.Jang-Gi ChoiYoung Soo KimJi Hye KimHwan-Suck ChungNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jang-Gi Choi Young Soo Kim Ji Hye Kim Hwan-Suck Chung Antiviral activity of ethanol extract of Geranii Herba and its components against influenza viruses via neuraminidase inhibition
description	Abstract Influenza viruses are a serious threat to human health, causing numerous deaths and pandemics worldwide. To date, neuraminidase (NA) inhibitors have primarily been used to treat influenza. However, there is a growing need for novel NA inhibitors owing to the emergence of resistant viruses. Geranii Herba (Geranium thunbergii Siebold et Zuccarini), which is edible, has long been used in a variety of disease treatments in Asia. Although recent studies have reported its various pharmacological activities, the effect of Geranii Herba and its components on influenza viruses has not yet been reported. In this study, Geranii Herba ethanol extract (GHE) and its component geraniin showed high antiviral activity against influenza A strain as well as influenza B strain, against which oseltamivir has less efficacy than influenza A strain, by inhibiting NA activity following viral infection in Madin–Darby canine kidney cells. Thus, GHE and its components may be useful for the development of anti-influenza drugs.
format	article
author	Jang-Gi Choi Young Soo Kim Ji Hye Kim Hwan-Suck Chung
author_facet	Jang-Gi Choi Young Soo Kim Ji Hye Kim Hwan-Suck Chung
author_sort	Jang-Gi Choi
title	Antiviral activity of ethanol extract of Geranii Herba and its components against influenza viruses via neuraminidase inhibition
title_short	Antiviral activity of ethanol extract of Geranii Herba and its components against influenza viruses via neuraminidase inhibition
title_full	Antiviral activity of ethanol extract of Geranii Herba and its components against influenza viruses via neuraminidase inhibition
title_fullStr	Antiviral activity of ethanol extract of Geranii Herba and its components against influenza viruses via neuraminidase inhibition
title_full_unstemmed	Antiviral activity of ethanol extract of Geranii Herba and its components against influenza viruses via neuraminidase inhibition
title_sort	antiviral activity of ethanol extract of geranii herba and its components against influenza viruses via neuraminidase inhibition
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/e470483ac082453fb2772cfc872135db
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Antiviral activity of ethanol extract of Geranii Herba and its components against influenza viruses via neuraminidase inhibition

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