Mito-priming as a method to engineer Bcl-2 addiction

Apoptosis often requires mitochondrial outer membrane permeabilization, a process targeted by Bcl-2-binding BH3 mimetics. Here the authors describe and apply 'mito-priming', a method that allows triggering mitochondrial apoptosis in a synchronous manner, facilitating the investigation of m...

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Autores principales:	Jonathan Lopez, Margaux Bessou, Joel S. Riley, Evangelos Giampazolias, Franziska Todt, Tony Rochegüe, Andrew Oberst, Douglas R. Green, Frank Edlich, Gabriel Ichim, Stephen W. G. Tait
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e472b3d9d4ce4cfebfc95bc127784369
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spelling	oai:doaj.org-article:e472b3d9d4ce4cfebfc95bc1277843692021-12-02T16:58:23ZMito-priming as a method to engineer Bcl-2 addiction10.1038/ncomms105382041-1723https://doaj.org/article/e472b3d9d4ce4cfebfc95bc1277843692016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10538https://doaj.org/toc/2041-1723Apoptosis often requires mitochondrial outer membrane permeabilization, a process targeted by Bcl-2-binding BH3 mimetics. Here the authors describe and apply 'mito-priming', a method that allows triggering mitochondrial apoptosis in a synchronous manner, facilitating the investigation of mitochondrial apoptosis and its regulation by Bcl-2 proteins.Jonathan LopezMargaux BessouJoel S. RileyEvangelos GiampazoliasFranziska TodtTony RochegüeAndrew OberstDouglas R. GreenFrank EdlichGabriel IchimStephen W. G. TaitNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jonathan Lopez Margaux Bessou Joel S. Riley Evangelos Giampazolias Franziska Todt Tony Rochegüe Andrew Oberst Douglas R. Green Frank Edlich Gabriel Ichim Stephen W. G. Tait Mito-priming as a method to engineer Bcl-2 addiction
description	Apoptosis often requires mitochondrial outer membrane permeabilization, a process targeted by Bcl-2-binding BH3 mimetics. Here the authors describe and apply 'mito-priming', a method that allows triggering mitochondrial apoptosis in a synchronous manner, facilitating the investigation of mitochondrial apoptosis and its regulation by Bcl-2 proteins.
format	article
author	Jonathan Lopez Margaux Bessou Joel S. Riley Evangelos Giampazolias Franziska Todt Tony Rochegüe Andrew Oberst Douglas R. Green Frank Edlich Gabriel Ichim Stephen W. G. Tait
author_facet	Jonathan Lopez Margaux Bessou Joel S. Riley Evangelos Giampazolias Franziska Todt Tony Rochegüe Andrew Oberst Douglas R. Green Frank Edlich Gabriel Ichim Stephen W. G. Tait
author_sort	Jonathan Lopez
title	Mito-priming as a method to engineer Bcl-2 addiction
title_short	Mito-priming as a method to engineer Bcl-2 addiction
title_full	Mito-priming as a method to engineer Bcl-2 addiction
title_fullStr	Mito-priming as a method to engineer Bcl-2 addiction
title_full_unstemmed	Mito-priming as a method to engineer Bcl-2 addiction
title_sort	mito-priming as a method to engineer bcl-2 addiction
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/e472b3d9d4ce4cfebfc95bc127784369
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Mito-priming as a method to engineer Bcl-2 addiction

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