Thioesterase superfamily member 1 undergoes stimulus-coupled conformational reorganization to regulate metabolism in mice

Cold exposure activates thermogenesis and fatty acid oxidation in brown fat, a process suppressed by Them1. Here, the authors show that cold induces Them1 phosphorylation and loss of puncta that suppress fatty acid use, leading to a diffuse localization and increased energy expenditure in mice.

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Autores principales:	Yue Li, Norihiro Imai, Hayley T. Nicholls, Blaine R. Roberts, Samaksh Goyal, Tibor I. Krisko, Lay-Hong Ang, Matthew C. Tillman, Anne M. Roberts, Mahnoor Baqai, Eric A. Ortlund, David E. Cohen, Susan J. Hagen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e474110267a740bcbae71a2b1885f9cd
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spelling	oai:doaj.org-article:e474110267a740bcbae71a2b1885f9cd2021-12-02T17:52:09ZThioesterase superfamily member 1 undergoes stimulus-coupled conformational reorganization to regulate metabolism in mice10.1038/s41467-021-23595-x2041-1723https://doaj.org/article/e474110267a740bcbae71a2b1885f9cd2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23595-xhttps://doaj.org/toc/2041-1723Cold exposure activates thermogenesis and fatty acid oxidation in brown fat, a process suppressed by Them1. Here, the authors show that cold induces Them1 phosphorylation and loss of puncta that suppress fatty acid use, leading to a diffuse localization and increased energy expenditure in mice.Yue LiNorihiro ImaiHayley T. NichollsBlaine R. RobertsSamaksh GoyalTibor I. KriskoLay-Hong AngMatthew C. TillmanAnne M. RobertsMahnoor BaqaiEric A. OrtlundDavid E. CohenSusan J. HagenNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yue Li Norihiro Imai Hayley T. Nicholls Blaine R. Roberts Samaksh Goyal Tibor I. Krisko Lay-Hong Ang Matthew C. Tillman Anne M. Roberts Mahnoor Baqai Eric A. Ortlund David E. Cohen Susan J. Hagen Thioesterase superfamily member 1 undergoes stimulus-coupled conformational reorganization to regulate metabolism in mice
description	Cold exposure activates thermogenesis and fatty acid oxidation in brown fat, a process suppressed by Them1. Here, the authors show that cold induces Them1 phosphorylation and loss of puncta that suppress fatty acid use, leading to a diffuse localization and increased energy expenditure in mice.
format	article
author	Yue Li Norihiro Imai Hayley T. Nicholls Blaine R. Roberts Samaksh Goyal Tibor I. Krisko Lay-Hong Ang Matthew C. Tillman Anne M. Roberts Mahnoor Baqai Eric A. Ortlund David E. Cohen Susan J. Hagen
author_facet	Yue Li Norihiro Imai Hayley T. Nicholls Blaine R. Roberts Samaksh Goyal Tibor I. Krisko Lay-Hong Ang Matthew C. Tillman Anne M. Roberts Mahnoor Baqai Eric A. Ortlund David E. Cohen Susan J. Hagen
author_sort	Yue Li
title	Thioesterase superfamily member 1 undergoes stimulus-coupled conformational reorganization to regulate metabolism in mice
title_short	Thioesterase superfamily member 1 undergoes stimulus-coupled conformational reorganization to regulate metabolism in mice
title_full	Thioesterase superfamily member 1 undergoes stimulus-coupled conformational reorganization to regulate metabolism in mice
title_fullStr	Thioesterase superfamily member 1 undergoes stimulus-coupled conformational reorganization to regulate metabolism in mice
title_full_unstemmed	Thioesterase superfamily member 1 undergoes stimulus-coupled conformational reorganization to regulate metabolism in mice
title_sort	thioesterase superfamily member 1 undergoes stimulus-coupled conformational reorganization to regulate metabolism in mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e474110267a740bcbae71a2b1885f9cd
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Thioesterase superfamily member 1 undergoes stimulus-coupled conformational reorganization to regulate metabolism in mice

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