Thioesterase superfamily member 1 undergoes stimulus-coupled conformational reorganization to regulate metabolism in mice

Thioesterase superfamily member 1 undergoes stimulus-coupled conformational reorganization to regulate metabolism in mice

Cold exposure activates thermogenesis and fatty acid oxidation in brown fat, a process suppressed by Them1. Here, the authors show that cold induces Them1 phosphorylation and loss of puncta that suppress fatty acid use, leading to a diffuse localization and increased energy expenditure in mice.

Saved in:
Bibliographic Details
Main Authors: Yue Li, Norihiro Imai, Hayley T. Nicholls, Blaine R. Roberts, Samaksh Goyal, Tibor I. Krisko, Lay-Hong Ang, Matthew C. Tillman, Anne M. Roberts, Mahnoor Baqai, Eric A. Ortlund, David E. Cohen, Susan J. Hagen
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Science
Q
Online Access:https://doaj.org/article/e474110267a740bcbae71a2b1885f9cd
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doaj.org/article/e474110267a740bcbae71a2b1885f9cd

Similar Items