An epitranscriptomic mechanism underlies selective mRNA translation remodelling in melanoma persister cells

Melanoma persister cells are tolerant to anti-BRAF and anti-MEK inhibition and can trigger cancer relapse. Here the authors show that a subset of N6-methyladenosine modified mRNAs is translationally activated in persister cells. This preferential translation can be abrogated via eIF4A inhibition.

Guardado en:

Detalles Bibliográficos
Autores principales:	Shensi Shen, Sara Faouzi, Amandine Bastide, Sylvain Martineau, Hélène Malka-Mahieu, Yu Fu, Xiaoxiao Sun, Christine Mateus, Emilie Routier, Severine Roy, Laurent Desaubry, Fabrice André, Alexander Eggermont, Alexandre David, Jean-Yves Scoazec, Stéphan Vagner, Caroline Robert
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e47491eb7c3744b2a9a1e54104826b8f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e47491eb7c3744b2a9a1e54104826b8f
record_format	dspace
spelling	oai:doaj.org-article:e47491eb7c3744b2a9a1e54104826b8f2021-12-02T17:33:10ZAn epitranscriptomic mechanism underlies selective mRNA translation remodelling in melanoma persister cells10.1038/s41467-019-13360-62041-1723https://doaj.org/article/e47491eb7c3744b2a9a1e54104826b8f2019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13360-6https://doaj.org/toc/2041-1723Melanoma persister cells are tolerant to anti-BRAF and anti-MEK inhibition and can trigger cancer relapse. Here the authors show that a subset of N6-methyladenosine modified mRNAs is translationally activated in persister cells. This preferential translation can be abrogated via eIF4A inhibition.Shensi ShenSara FaouziAmandine BastideSylvain MartineauHélène Malka-MahieuYu FuXiaoxiao SunChristine MateusEmilie RoutierSeverine RoyLaurent DesaubryFabrice AndréAlexander EggermontAlexandre DavidJean-Yves ScoazecStéphan VagnerCaroline RobertNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shensi Shen Sara Faouzi Amandine Bastide Sylvain Martineau Hélène Malka-Mahieu Yu Fu Xiaoxiao Sun Christine Mateus Emilie Routier Severine Roy Laurent Desaubry Fabrice André Alexander Eggermont Alexandre David Jean-Yves Scoazec Stéphan Vagner Caroline Robert An epitranscriptomic mechanism underlies selective mRNA translation remodelling in melanoma persister cells
description	Melanoma persister cells are tolerant to anti-BRAF and anti-MEK inhibition and can trigger cancer relapse. Here the authors show that a subset of N6-methyladenosine modified mRNAs is translationally activated in persister cells. This preferential translation can be abrogated via eIF4A inhibition.
format	article
author	Shensi Shen Sara Faouzi Amandine Bastide Sylvain Martineau Hélène Malka-Mahieu Yu Fu Xiaoxiao Sun Christine Mateus Emilie Routier Severine Roy Laurent Desaubry Fabrice André Alexander Eggermont Alexandre David Jean-Yves Scoazec Stéphan Vagner Caroline Robert
author_facet	Shensi Shen Sara Faouzi Amandine Bastide Sylvain Martineau Hélène Malka-Mahieu Yu Fu Xiaoxiao Sun Christine Mateus Emilie Routier Severine Roy Laurent Desaubry Fabrice André Alexander Eggermont Alexandre David Jean-Yves Scoazec Stéphan Vagner Caroline Robert
author_sort	Shensi Shen
title	An epitranscriptomic mechanism underlies selective mRNA translation remodelling in melanoma persister cells
title_short	An epitranscriptomic mechanism underlies selective mRNA translation remodelling in melanoma persister cells
title_full	An epitranscriptomic mechanism underlies selective mRNA translation remodelling in melanoma persister cells
title_fullStr	An epitranscriptomic mechanism underlies selective mRNA translation remodelling in melanoma persister cells
title_full_unstemmed	An epitranscriptomic mechanism underlies selective mRNA translation remodelling in melanoma persister cells
title_sort	epitranscriptomic mechanism underlies selective mrna translation remodelling in melanoma persister cells
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/e47491eb7c3744b2a9a1e54104826b8f
work_keys_str_mv	AT shensishen anepitranscriptomicmechanismunderliesselectivemrnatranslationremodellinginmelanomapersistercells AT sarafaouzi anepitranscriptomicmechanismunderliesselectivemrnatranslationremodellinginmelanomapersistercells AT amandinebastide anepitranscriptomicmechanismunderliesselectivemrnatranslationremodellinginmelanomapersistercells AT sylvainmartineau anepitranscriptomicmechanismunderliesselectivemrnatranslationremodellinginmelanomapersistercells AT helenemalkamahieu anepitranscriptomicmechanismunderliesselectivemrnatranslationremodellinginmelanomapersistercells AT yufu anepitranscriptomicmechanismunderliesselectivemrnatranslationremodellinginmelanomapersistercells AT xiaoxiaosun anepitranscriptomicmechanismunderliesselectivemrnatranslationremodellinginmelanomapersistercells AT christinemateus anepitranscriptomicmechanismunderliesselectivemrnatranslationremodellinginmelanomapersistercells AT emilieroutier anepitranscriptomicmechanismunderliesselectivemrnatranslationremodellinginmelanomapersistercells AT severineroy anepitranscriptomicmechanismunderliesselectivemrnatranslationremodellinginmelanomapersistercells AT laurentdesaubry anepitranscriptomicmechanismunderliesselectivemrnatranslationremodellinginmelanomapersistercells AT fabriceandre anepitranscriptomicmechanismunderliesselectivemrnatranslationremodellinginmelanomapersistercells AT alexandereggermont anepitranscriptomicmechanismunderliesselectivemrnatranslationremodellinginmelanomapersistercells AT alexandredavid anepitranscriptomicmechanismunderliesselectivemrnatranslationremodellinginmelanomapersistercells AT jeanyvesscoazec anepitranscriptomicmechanismunderliesselectivemrnatranslationremodellinginmelanomapersistercells AT stephanvagner anepitranscriptomicmechanismunderliesselectivemrnatranslationremodellinginmelanomapersistercells AT carolinerobert anepitranscriptomicmechanismunderliesselectivemrnatranslationremodellinginmelanomapersistercells AT shensishen epitranscriptomicmechanismunderliesselectivemrnatranslationremodellinginmelanomapersistercells AT sarafaouzi epitranscriptomicmechanismunderliesselectivemrnatranslationremodellinginmelanomapersistercells AT amandinebastide epitranscriptomicmechanismunderliesselectivemrnatranslationremodellinginmelanomapersistercells AT sylvainmartineau epitranscriptomicmechanismunderliesselectivemrnatranslationremodellinginmelanomapersistercells AT helenemalkamahieu epitranscriptomicmechanismunderliesselectivemrnatranslationremodellinginmelanomapersistercells AT yufu epitranscriptomicmechanismunderliesselectivemrnatranslationremodellinginmelanomapersistercells AT xiaoxiaosun epitranscriptomicmechanismunderliesselectivemrnatranslationremodellinginmelanomapersistercells AT christinemateus epitranscriptomicmechanismunderliesselectivemrnatranslationremodellinginmelanomapersistercells AT emilieroutier epitranscriptomicmechanismunderliesselectivemrnatranslationremodellinginmelanomapersistercells AT severineroy epitranscriptomicmechanismunderliesselectivemrnatranslationremodellinginmelanomapersistercells AT laurentdesaubry epitranscriptomicmechanismunderliesselectivemrnatranslationremodellinginmelanomapersistercells AT fabriceandre epitranscriptomicmechanismunderliesselectivemrnatranslationremodellinginmelanomapersistercells AT alexandereggermont epitranscriptomicmechanismunderliesselectivemrnatranslationremodellinginmelanomapersistercells AT alexandredavid epitranscriptomicmechanismunderliesselectivemrnatranslationremodellinginmelanomapersistercells AT jeanyvesscoazec epitranscriptomicmechanismunderliesselectivemrnatranslationremodellinginmelanomapersistercells AT stephanvagner epitranscriptomicmechanismunderliesselectivemrnatranslationremodellinginmelanomapersistercells AT carolinerobert epitranscriptomicmechanismunderliesselectivemrnatranslationremodellinginmelanomapersistercells
_version_	1718380094393679872

An epitranscriptomic mechanism underlies selective mRNA translation remodelling in melanoma persister cells

Ejemplares similares