An epitranscriptomic mechanism underlies selective mRNA translation remodelling in melanoma persister cells

An epitranscriptomic mechanism underlies selective mRNA translation remodelling in melanoma persister cells

Melanoma persister cells are tolerant to anti-BRAF and anti-MEK inhibition and can trigger cancer relapse. Here the authors show that a subset of N6-methyladenosine modified mRNAs is translationally activated in persister cells. This preferential translation can be abrogated via eIF4A inhibition.

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Auteurs principaux: Shensi Shen, Sara Faouzi, Amandine Bastide, Sylvain Martineau, Hélène Malka-Mahieu, Yu Fu, Xiaoxiao Sun, Christine Mateus, Emilie Routier, Severine Roy, Laurent Desaubry, Fabrice André, Alexander Eggermont, Alexandre David, Jean-Yves Scoazec, Stéphan Vagner, Caroline Robert
Format: article
Langue:EN
Publié: Nature Portfolio 2019
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Science
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Accès en ligne:https://doaj.org/article/e47491eb7c3744b2a9a1e54104826b8f
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Internet

https://doaj.org/article/e47491eb7c3744b2a9a1e54104826b8f

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