A Four-Step Cascade Drug-Release Management Strategy for Transcatheter Arterial Chemoembolization (TACE) Therapeutic Applications

The purpose of this study was to develop a four-step cascade drug-release system for transcatheter arterial chemoembolization (TACE) therapeutic applications according to disease-driven and patient-focused design theories. The four steps underlying these strategies involve the blockage of nutrient s...

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Autores principales:	Ying-Jiun Hsieh, Hung-Wei Cheng, Hung-Yu Chen, Ming-Wei Lee
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cascade antitumor drug delivery gellan gum polysaccharide graphene nanoparticles transcatheter arterial chemoembolization Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/e474d34fa1884ed19c8a7a997a4641c6
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spelling	oai:doaj.org-article:e474d34fa1884ed19c8a7a997a4641c62021-11-11T18:44:16ZA Four-Step Cascade Drug-Release Management Strategy for Transcatheter Arterial Chemoembolization (TACE) Therapeutic Applications10.3390/polym132137012073-4360https://doaj.org/article/e474d34fa1884ed19c8a7a997a4641c62021-10-01T00:00:00Zhttps://www.mdpi.com/2073-4360/13/21/3701https://doaj.org/toc/2073-4360The purpose of this study was to develop a four-step cascade drug-release system for transcatheter arterial chemoembolization (TACE) therapeutic applications according to disease-driven and patient-focused design theories. The four steps underlying these strategies involve the blockage of nutrient supply, nanoparticles, codelivery and the cell cytotoxic effect. Calibrated spherical gellan gum (GG) and nanoparticle-containing gellan gum microspheres were prepared using a water-in-oil emulsification method. Self-assembled nanoparticles featuring amine-functionalized graphene oxide (AFGO) as the doxorubicin (Dox) carrier were prepared. The results confirm that, as a drug carrier, AFGO–Dox nanoparticles can facilitate the transport of doxorubicin into HepG2 liver cancer cells. Subsequently, AFGO–Dox was introduced into gellan gum (GG) microspheres, thus forming GG/AFGO–Dox microspheres with a mean size of 200–700 μm. After a drug release experiment lasting 28 days, the amount of doxorubicin released from 674 and 226 μm GG/AFGO–Dox microspheres was 2.31 and 1.18 μg/mg, respectively. GG/AFGO–Dox microspheres were applied in a rabbit ear embolization model, where ischemic necrosis was visible on the ear after 12 days. Our aim for the future is to provide better embolization agents for transcatheter arterial chemoembolization (TACE) using this device.Ying-Jiun HsiehHung-Wei ChengHung-Yu ChenMing-Wei LeeMDPI AGarticlecascade antitumor drug deliverygellan gum polysaccharidegraphene nanoparticlestranscatheter arterial chemoembolizationOrganic chemistryQD241-441ENPolymers, Vol 13, Iss 3701, p 3701 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cascade antitumor drug delivery gellan gum polysaccharide graphene nanoparticles transcatheter arterial chemoembolization Organic chemistry QD241-441
spellingShingle	cascade antitumor drug delivery gellan gum polysaccharide graphene nanoparticles transcatheter arterial chemoembolization Organic chemistry QD241-441 Ying-Jiun Hsieh Hung-Wei Cheng Hung-Yu Chen Ming-Wei Lee A Four-Step Cascade Drug-Release Management Strategy for Transcatheter Arterial Chemoembolization (TACE) Therapeutic Applications
description	The purpose of this study was to develop a four-step cascade drug-release system for transcatheter arterial chemoembolization (TACE) therapeutic applications according to disease-driven and patient-focused design theories. The four steps underlying these strategies involve the blockage of nutrient supply, nanoparticles, codelivery and the cell cytotoxic effect. Calibrated spherical gellan gum (GG) and nanoparticle-containing gellan gum microspheres were prepared using a water-in-oil emulsification method. Self-assembled nanoparticles featuring amine-functionalized graphene oxide (AFGO) as the doxorubicin (Dox) carrier were prepared. The results confirm that, as a drug carrier, AFGO–Dox nanoparticles can facilitate the transport of doxorubicin into HepG2 liver cancer cells. Subsequently, AFGO–Dox was introduced into gellan gum (GG) microspheres, thus forming GG/AFGO–Dox microspheres with a mean size of 200–700 μm. After a drug release experiment lasting 28 days, the amount of doxorubicin released from 674 and 226 μm GG/AFGO–Dox microspheres was 2.31 and 1.18 μg/mg, respectively. GG/AFGO–Dox microspheres were applied in a rabbit ear embolization model, where ischemic necrosis was visible on the ear after 12 days. Our aim for the future is to provide better embolization agents for transcatheter arterial chemoembolization (TACE) using this device.
format	article
author	Ying-Jiun Hsieh Hung-Wei Cheng Hung-Yu Chen Ming-Wei Lee
author_facet	Ying-Jiun Hsieh Hung-Wei Cheng Hung-Yu Chen Ming-Wei Lee
author_sort	Ying-Jiun Hsieh
title	A Four-Step Cascade Drug-Release Management Strategy for Transcatheter Arterial Chemoembolization (TACE) Therapeutic Applications
title_short	A Four-Step Cascade Drug-Release Management Strategy for Transcatheter Arterial Chemoembolization (TACE) Therapeutic Applications
title_full	A Four-Step Cascade Drug-Release Management Strategy for Transcatheter Arterial Chemoembolization (TACE) Therapeutic Applications
title_fullStr	A Four-Step Cascade Drug-Release Management Strategy for Transcatheter Arterial Chemoembolization (TACE) Therapeutic Applications
title_full_unstemmed	A Four-Step Cascade Drug-Release Management Strategy for Transcatheter Arterial Chemoembolization (TACE) Therapeutic Applications
title_sort	four-step cascade drug-release management strategy for transcatheter arterial chemoembolization (tace) therapeutic applications
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/e474d34fa1884ed19c8a7a997a4641c6
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A Four-Step Cascade Drug-Release Management Strategy for Transcatheter Arterial Chemoembolization (TACE) Therapeutic Applications

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