Medicinal properties of Morus alba for the control of type 2 diabetes mellitus: a systematic review [version 1; peer review: 2 approved]

Background: The objective of this review was to evaluate the medicinal potential of Morus alba leaves on the control of type 2 diabetes mellitus (DM2). The research question was: what is the therapeutic potential of Morus alba leaves for the control of DM2? Methods: This systematic review was based...

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Autores principales:	Jorge Guillermo Morales Ramos, Ambrocio Teodoro Esteves Pairazamán, María Ema Soledad Mocarro Willis, Samuel Collantes Santisteban, Emma Caldas Herrera
Formato:	article
Lenguaje:	EN
Publicado:	F1000 Research Ltd 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e47c8ee4fadb4d8c8573130c5125a51e
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spelling	oai:doaj.org-article:e47c8ee4fadb4d8c8573130c5125a51e2021-11-22T12:41:06ZMedicinal properties of Morus alba for the control of type 2 diabetes mellitus: a systematic review [version 1; peer review: 2 approved]2046-140210.12688/f1000research.55573.1https://doaj.org/article/e47c8ee4fadb4d8c8573130c5125a51e2021-10-01T00:00:00Zhttps://f1000research.com/articles/10-1022/v1https://doaj.org/toc/2046-1402Background: The objective of this review was to evaluate the medicinal potential of Morus alba leaves on the control of type 2 diabetes mellitus (DM2). The research question was: what is the therapeutic potential of Morus alba leaves for the control of DM2? Methods: This systematic review was based on the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. The included studies were extracted from Scopus, Pubmed, ScienceDirect, Scielo, and Google Scholar; January 2015 to July 2021. Key search terms were MeSH and DeCS: Morus alba, mulberry, hypoglycemic agent. The inclusion criteria were: studies in rats administered Morus alba leaf extracts; studies that included the dimensions of lipidemia and glycemia; studies that included indicators such as fasting glucose, postprandial glucose, glycosylated hemoglobin, triglycerides, low-density lipoproteins, total cholesterol, and insulin resistance. Exclusion criteria: studies in which Morus alba leaves were administered with other plants; studies with other parts of the Morus alba plant; proteomic studies, cancer, duplicate studies, in vitro studies, and evaluation of included studies. All included investigations were evaluated for biases. Results: Of 253 studies found, 29 were included. The extracts of Morus alba leaves at the phytochemical level improve glucose uptake. Chlorogenic acid, isoquercitrin, and quercitrin, present in the leaves of Morus alba, have hypoglycemic properties and an ameliorating effect on diabetic nephropathy. This leaf has pharmacological effects such as glucose absorption, insulin secretion production, antioxidant and anti-inflammatory agent, antihyperglycemic and antihyperlipidemic activities, and obesity management. Conclusions: Morus alba leaves have pharmacological effects on DM2 that include glucose absorption, production of insulin secretion, antioxidant agent, antihyperglycemic and antihyperlipidemic activities, and obesity control. Beyond these results, there is a lack of studies on the potential and synergistic effects of Morus alba leaves' components, limiting the possibility of a more effective therapy using the plant's leaves.Jorge Guillermo Morales RamosAmbrocio Teodoro Esteves PairazamánMaría Ema Soledad Mocarro WillisSamuel Collantes SantistebanEmma Caldas HerreraF1000 Research LtdarticleMedicineRScienceQENF1000Research, Vol 10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jorge Guillermo Morales Ramos Ambrocio Teodoro Esteves Pairazamán María Ema Soledad Mocarro Willis Samuel Collantes Santisteban Emma Caldas Herrera Medicinal properties of Morus alba for the control of type 2 diabetes mellitus: a systematic review [version 1; peer review: 2 approved]
description	Background: The objective of this review was to evaluate the medicinal potential of Morus alba leaves on the control of type 2 diabetes mellitus (DM2). The research question was: what is the therapeutic potential of Morus alba leaves for the control of DM2? Methods: This systematic review was based on the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. The included studies were extracted from Scopus, Pubmed, ScienceDirect, Scielo, and Google Scholar; January 2015 to July 2021. Key search terms were MeSH and DeCS: Morus alba, mulberry, hypoglycemic agent. The inclusion criteria were: studies in rats administered Morus alba leaf extracts; studies that included the dimensions of lipidemia and glycemia; studies that included indicators such as fasting glucose, postprandial glucose, glycosylated hemoglobin, triglycerides, low-density lipoproteins, total cholesterol, and insulin resistance. Exclusion criteria: studies in which Morus alba leaves were administered with other plants; studies with other parts of the Morus alba plant; proteomic studies, cancer, duplicate studies, in vitro studies, and evaluation of included studies. All included investigations were evaluated for biases. Results: Of 253 studies found, 29 were included. The extracts of Morus alba leaves at the phytochemical level improve glucose uptake. Chlorogenic acid, isoquercitrin, and quercitrin, present in the leaves of Morus alba, have hypoglycemic properties and an ameliorating effect on diabetic nephropathy. This leaf has pharmacological effects such as glucose absorption, insulin secretion production, antioxidant and anti-inflammatory agent, antihyperglycemic and antihyperlipidemic activities, and obesity management. Conclusions: Morus alba leaves have pharmacological effects on DM2 that include glucose absorption, production of insulin secretion, antioxidant agent, antihyperglycemic and antihyperlipidemic activities, and obesity control. Beyond these results, there is a lack of studies on the potential and synergistic effects of Morus alba leaves' components, limiting the possibility of a more effective therapy using the plant's leaves.
format	article
author	Jorge Guillermo Morales Ramos Ambrocio Teodoro Esteves Pairazamán María Ema Soledad Mocarro Willis Samuel Collantes Santisteban Emma Caldas Herrera
author_facet	Jorge Guillermo Morales Ramos Ambrocio Teodoro Esteves Pairazamán María Ema Soledad Mocarro Willis Samuel Collantes Santisteban Emma Caldas Herrera
author_sort	Jorge Guillermo Morales Ramos
title	Medicinal properties of Morus alba for the control of type 2 diabetes mellitus: a systematic review [version 1; peer review: 2 approved]
title_short	Medicinal properties of Morus alba for the control of type 2 diabetes mellitus: a systematic review [version 1; peer review: 2 approved]
title_full	Medicinal properties of Morus alba for the control of type 2 diabetes mellitus: a systematic review [version 1; peer review: 2 approved]
title_fullStr	Medicinal properties of Morus alba for the control of type 2 diabetes mellitus: a systematic review [version 1; peer review: 2 approved]
title_full_unstemmed	Medicinal properties of Morus alba for the control of type 2 diabetes mellitus: a systematic review [version 1; peer review: 2 approved]
title_sort	medicinal properties of morus alba for the control of type 2 diabetes mellitus: a systematic review [version 1; peer review: 2 approved]
publisher	F1000 Research Ltd
publishDate	2021
url	https://doaj.org/article/e47c8ee4fadb4d8c8573130c5125a51e
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Medicinal properties of Morus alba for the control of type 2 diabetes mellitus: a systematic review [version 1; peer review: 2 approved]

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