CT air trapping is independently associated with lung function reduction over time.
<h4>Purpose</h4>We aimed to study the association between lung function decline and quantitative computed tomography (CT) air trapping.<h4>Materials and methods</h4>Current and former heavy smokers in a lung cancer screening trial underwent volumetric low-dose CT in inspirati...
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| Autores principales: | , , , , , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Public Library of Science (PLoS)
2013
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/e47d21896f474e38a3e3b186878ea66e |
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| Sumario: | <h4>Purpose</h4>We aimed to study the association between lung function decline and quantitative computed tomography (CT) air trapping.<h4>Materials and methods</h4>Current and former heavy smokers in a lung cancer screening trial underwent volumetric low-dose CT in inspiration and expiration. Spirometry was obtained at baseline and after 3 years. The expiratory to inspiratory ratio of mean lung density (E/I-ratioMLD) was used to quantify air trapping. CT emphysema was defined as voxels in inspiratory CT below -950 Hounsfield Unit. Linear mixed modeling was used to determine the association between CT air trapping and lung function.<h4>Results</h4>We included 985 subjects with a mean age of 61.3 years. Independent of CT emphysema, CT air trapping was significantly associated with a reduction in forced expiratory volume in one second (FEV1) and the ratio of FEV1 over the forced vital capacity (FEV1/FVC); FEV1 declines with 33 mL per percent increase in CT air trapping, while FEV1/FVC declines 0.58% per percent increase (both p<0.001). CT air trapping further elicits accelerated loss of FEV1/FVC (additional 0.24% reduction per percent increase; p = 0.014).<h4>Conclusion</h4>In a lung cancer screening cohort, quantitatively assessed air trapping on low-dose CT is independently associated with reduced lung function and accelerated decline of FEV1/FVC. |
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