CT air trapping is independently associated with lung function reduction over time.

<h4>Purpose</h4>We aimed to study the association between lung function decline and quantitative computed tomography (CT) air trapping.<h4>Materials and methods</h4>Current and former heavy smokers in a lung cancer screening trial underwent volumetric low-dose CT in inspirati...

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Autores principales:	Onno M Mets, Pim A de Jong, Bram van Ginneken, Cas L J J Kruitwagen, Mathias Prokop, Matthijs Oudkerk, Jan-Willem J Lammers, Pieter Zanen
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e47d21896f474e38a3e3b186878ea66e
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spelling	oai:doaj.org-article:e47d21896f474e38a3e3b186878ea66e2021-11-18T07:49:16ZCT air trapping is independently associated with lung function reduction over time.1932-620310.1371/journal.pone.0061783https://doaj.org/article/e47d21896f474e38a3e3b186878ea66e2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23613934/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Purpose</h4>We aimed to study the association between lung function decline and quantitative computed tomography (CT) air trapping.<h4>Materials and methods</h4>Current and former heavy smokers in a lung cancer screening trial underwent volumetric low-dose CT in inspiration and expiration. Spirometry was obtained at baseline and after 3 years. The expiratory to inspiratory ratio of mean lung density (E/I-ratioMLD) was used to quantify air trapping. CT emphysema was defined as voxels in inspiratory CT below -950 Hounsfield Unit. Linear mixed modeling was used to determine the association between CT air trapping and lung function.<h4>Results</h4>We included 985 subjects with a mean age of 61.3 years. Independent of CT emphysema, CT air trapping was significantly associated with a reduction in forced expiratory volume in one second (FEV1) and the ratio of FEV1 over the forced vital capacity (FEV1/FVC); FEV1 declines with 33 mL per percent increase in CT air trapping, while FEV1/FVC declines 0.58% per percent increase (both p<0.001). CT air trapping further elicits accelerated loss of FEV1/FVC (additional 0.24% reduction per percent increase; p = 0.014).<h4>Conclusion</h4>In a lung cancer screening cohort, quantitatively assessed air trapping on low-dose CT is independently associated with reduced lung function and accelerated decline of FEV1/FVC.Onno M MetsPim A de JongBram van GinnekenCas L J J KruitwagenMathias ProkopMatthijs OudkerkJan-Willem J LammersPieter ZanenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 4, p e61783 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Onno M Mets Pim A de Jong Bram van Ginneken Cas L J J Kruitwagen Mathias Prokop Matthijs Oudkerk Jan-Willem J Lammers Pieter Zanen CT air trapping is independently associated with lung function reduction over time.
description	<h4>Purpose</h4>We aimed to study the association between lung function decline and quantitative computed tomography (CT) air trapping.<h4>Materials and methods</h4>Current and former heavy smokers in a lung cancer screening trial underwent volumetric low-dose CT in inspiration and expiration. Spirometry was obtained at baseline and after 3 years. The expiratory to inspiratory ratio of mean lung density (E/I-ratioMLD) was used to quantify air trapping. CT emphysema was defined as voxels in inspiratory CT below -950 Hounsfield Unit. Linear mixed modeling was used to determine the association between CT air trapping and lung function.<h4>Results</h4>We included 985 subjects with a mean age of 61.3 years. Independent of CT emphysema, CT air trapping was significantly associated with a reduction in forced expiratory volume in one second (FEV1) and the ratio of FEV1 over the forced vital capacity (FEV1/FVC); FEV1 declines with 33 mL per percent increase in CT air trapping, while FEV1/FVC declines 0.58% per percent increase (both p<0.001). CT air trapping further elicits accelerated loss of FEV1/FVC (additional 0.24% reduction per percent increase; p = 0.014).<h4>Conclusion</h4>In a lung cancer screening cohort, quantitatively assessed air trapping on low-dose CT is independently associated with reduced lung function and accelerated decline of FEV1/FVC.
format	article
author	Onno M Mets Pim A de Jong Bram van Ginneken Cas L J J Kruitwagen Mathias Prokop Matthijs Oudkerk Jan-Willem J Lammers Pieter Zanen
author_facet	Onno M Mets Pim A de Jong Bram van Ginneken Cas L J J Kruitwagen Mathias Prokop Matthijs Oudkerk Jan-Willem J Lammers Pieter Zanen
author_sort	Onno M Mets
title	CT air trapping is independently associated with lung function reduction over time.
title_short	CT air trapping is independently associated with lung function reduction over time.
title_full	CT air trapping is independently associated with lung function reduction over time.
title_fullStr	CT air trapping is independently associated with lung function reduction over time.
title_full_unstemmed	CT air trapping is independently associated with lung function reduction over time.
title_sort	ct air trapping is independently associated with lung function reduction over time.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/e47d21896f474e38a3e3b186878ea66e
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CT air trapping is independently associated with lung function reduction over time.

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