Genomic retargeting of p53 and CTCF is associated with transcriptional changes during oncogenic HRas-induced transformation

By integrating transcriptome, regulatory element and chromosome topology profiles, Schwartz et al identify redistribution of p53 and CTCF genomic binding to be associated with transcriptional and phenotypical changes during Ras-induced transformation of mammary epithelial cells.

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Autores principales:	Michal Schwartz, Avital Sarusi Portugez, Bracha Zukerman Attia, Miriam Tannenbaum, Leslie Cohen, Olga Loza, Emily Chase, Yousef Turman, Tommy Kaplan, Zaidoun Salah, Ofir Hakim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/e4807e6b0f784e52bfe2be1bc98671aa
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spelling	oai:doaj.org-article:e4807e6b0f784e52bfe2be1bc98671aa2021-12-02T15:18:51ZGenomic retargeting of p53 and CTCF is associated with transcriptional changes during oncogenic HRas-induced transformation10.1038/s42003-020-01398-y2399-3642https://doaj.org/article/e4807e6b0f784e52bfe2be1bc98671aa2020-11-01T00:00:00Zhttps://doi.org/10.1038/s42003-020-01398-yhttps://doaj.org/toc/2399-3642By integrating transcriptome, regulatory element and chromosome topology profiles, Schwartz et al identify redistribution of p53 and CTCF genomic binding to be associated with transcriptional and phenotypical changes during Ras-induced transformation of mammary epithelial cells.Michal SchwartzAvital Sarusi PortugezBracha Zukerman AttiaMiriam TannenbaumLeslie CohenOlga LozaEmily ChaseYousef TurmanTommy KaplanZaidoun SalahOfir HakimNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 3, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Michal Schwartz Avital Sarusi Portugez Bracha Zukerman Attia Miriam Tannenbaum Leslie Cohen Olga Loza Emily Chase Yousef Turman Tommy Kaplan Zaidoun Salah Ofir Hakim Genomic retargeting of p53 and CTCF is associated with transcriptional changes during oncogenic HRas-induced transformation
description	By integrating transcriptome, regulatory element and chromosome topology profiles, Schwartz et al identify redistribution of p53 and CTCF genomic binding to be associated with transcriptional and phenotypical changes during Ras-induced transformation of mammary epithelial cells.
format	article
author	Michal Schwartz Avital Sarusi Portugez Bracha Zukerman Attia Miriam Tannenbaum Leslie Cohen Olga Loza Emily Chase Yousef Turman Tommy Kaplan Zaidoun Salah Ofir Hakim
author_facet	Michal Schwartz Avital Sarusi Portugez Bracha Zukerman Attia Miriam Tannenbaum Leslie Cohen Olga Loza Emily Chase Yousef Turman Tommy Kaplan Zaidoun Salah Ofir Hakim
author_sort	Michal Schwartz
title	Genomic retargeting of p53 and CTCF is associated with transcriptional changes during oncogenic HRas-induced transformation
title_short	Genomic retargeting of p53 and CTCF is associated with transcriptional changes during oncogenic HRas-induced transformation
title_full	Genomic retargeting of p53 and CTCF is associated with transcriptional changes during oncogenic HRas-induced transformation
title_fullStr	Genomic retargeting of p53 and CTCF is associated with transcriptional changes during oncogenic HRas-induced transformation
title_full_unstemmed	Genomic retargeting of p53 and CTCF is associated with transcriptional changes during oncogenic HRas-induced transformation
title_sort	genomic retargeting of p53 and ctcf is associated with transcriptional changes during oncogenic hras-induced transformation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e4807e6b0f784e52bfe2be1bc98671aa
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Genomic retargeting of p53 and CTCF is associated with transcriptional changes during oncogenic HRas-induced transformation

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