Paracrine cyclooxygenase-2 activity by macrophages drives colorectal adenoma progression in the Apc Min/+ mouse model of intestinal tumorigenesis

Abstract Genetic deletion or pharmacological inhibition of cyclooxygenase (COX)-2 abrogates intestinal adenoma development at early stages of colorectal carcinogenesis. COX-2 is localised to stromal cells (predominantly macrophages) in human and mouse intestinal adenomas. Therefore, we tested the hy...

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Autores principales: Mark A. Hull, Richard J. Cuthbert, C. W. Stanley Ko, Daniel J. Scott, Elizabeth J. Cartwright, Gillian Hawcroft, Sarah L. Perry, Nicola Ingram, Ian M. Carr, Alexander F. Markham, Constanze Bonifer, P. Louise Coletta
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/e481426f4bf8467fae7994ac44635d17
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