Spatiotemporal dynamics of 53BP1 dimer recruitment to a DNA double strand break

Spatiotemporal dynamics of 53BP1 dimer recruitment to a DNA double strand break

53BP1 is a crucial factor involved in double strand break repair which blocks DNA end resection affecting DNA repair pathway choice. Here the authors reveal by live cell nuclear architecture analysis the spatiotemporal dynamics of 53BP1 oligomerization during a DSB DNA damage response.

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Auteurs principaux: Jieqiong Lou, David G. Priest, Ashleigh Solano, Adèle Kerjouan, Elizabeth Hinde
Format: article
Langue:EN
Publié: Nature Portfolio 2020
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Science
Q
Accès en ligne:https://doaj.org/article/e48284b5b37449da83b9cc38e07d02f1
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id oai:doaj.org-article:e48284b5b37449da83b9cc38e07d02f1
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spelling oai:doaj.org-article:e48284b5b37449da83b9cc38e07d02f12021-12-02T15:33:51ZSpatiotemporal dynamics of 53BP1 dimer recruitment to a DNA double strand break10.1038/s41467-020-19504-32041-1723https://doaj.org/article/e48284b5b37449da83b9cc38e07d02f12020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19504-3https://doaj.org/toc/2041-172353BP1 is a crucial factor involved in double strand break repair which blocks DNA end resection affecting DNA repair pathway choice. Here the authors reveal by live cell nuclear architecture analysis the spatiotemporal dynamics of 53BP1 oligomerization during a DSB DNA damage response.Jieqiong LouDavid G. PriestAshleigh SolanoAdèle KerjouanElizabeth HindeNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jieqiong Lou
David G. Priest
Ashleigh Solano
Adèle Kerjouan
Elizabeth Hinde
Spatiotemporal dynamics of 53BP1 dimer recruitment to a DNA double strand break
description 53BP1 is a crucial factor involved in double strand break repair which blocks DNA end resection affecting DNA repair pathway choice. Here the authors reveal by live cell nuclear architecture analysis the spatiotemporal dynamics of 53BP1 oligomerization during a DSB DNA damage response.
format article
author Jieqiong Lou
David G. Priest
Ashleigh Solano
Adèle Kerjouan
Elizabeth Hinde
author_facet Jieqiong Lou
David G. Priest
Ashleigh Solano
Adèle Kerjouan
Elizabeth Hinde
author_sort Jieqiong Lou
title Spatiotemporal dynamics of 53BP1 dimer recruitment to a DNA double strand break
title_short Spatiotemporal dynamics of 53BP1 dimer recruitment to a DNA double strand break
title_full Spatiotemporal dynamics of 53BP1 dimer recruitment to a DNA double strand break
title_fullStr Spatiotemporal dynamics of 53BP1 dimer recruitment to a DNA double strand break
title_full_unstemmed Spatiotemporal dynamics of 53BP1 dimer recruitment to a DNA double strand break
title_sort spatiotemporal dynamics of 53bp1 dimer recruitment to a dna double strand break
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/e48284b5b37449da83b9cc38e07d02f1
work_keys_str_mv AT jieqionglou spatiotemporaldynamicsof53bp1dimerrecruitmenttoadnadoublestrandbreak
AT davidgpriest spatiotemporaldynamicsof53bp1dimerrecruitmenttoadnadoublestrandbreak
AT ashleighsolano spatiotemporaldynamicsof53bp1dimerrecruitmenttoadnadoublestrandbreak
AT adelekerjouan spatiotemporaldynamicsof53bp1dimerrecruitmenttoadnadoublestrandbreak
AT elizabethhinde spatiotemporaldynamicsof53bp1dimerrecruitmenttoadnadoublestrandbreak
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