T-cell receptor repertoires as potential diagnostic markers for patients with COVID-19
Objective: Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an ongoing global health emergency. T-cell receptors (TCRs) are crucial mediators of antiviral adaptive immunity. This study sought to comprehensively characterize the TCR reper...
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Elsevier
2021
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oai:doaj.org-article:e4863b545e454bbb99cb8e3dec682e832021-11-16T04:09:13ZT-cell receptor repertoires as potential diagnostic markers for patients with COVID-191201-971210.1016/j.ijid.2021.10.033https://doaj.org/article/e4863b545e454bbb99cb8e3dec682e832021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1201971221008201https://doaj.org/toc/1201-9712Objective: Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an ongoing global health emergency. T-cell receptors (TCRs) are crucial mediators of antiviral adaptive immunity. This study sought to comprehensively characterize the TCR repertoire changes in patients with COVID-19. Methods: A large sample size multi-center randomized controlled trial was implemented to study the features of the TCR repertoire and identify COVID-19 disease-related TCR sequences. Results: It was found that some T-cell receptor beta chain (TCRβ) features differed markedly between COVID-19 patients and healthy controls, including decreased repertoire diversity, longer complementarity-determining region 3 (CDR3) length, skewed utilization of the TCRβ variable gene/joining gene (TRBV/J), and a high degree of TCRβ sharing in COVID-19 patients. Moreover, this analysis showed that TCR repertoire diversity declines with aging, which may be a cause of the higher infection and mortality rates in elderly patients. Importantly, a set of TCRβ clones that can distinguish COVID-19 patients from healthy controls with high accuracy was identified. Notably, this diagnostic model demonstrates 100% specificity and 82.68% sensitivity at 0–3 days post diagnosis. Conclusions: This study lays the foundation for immunodiagnosis and the development of medicines and vaccines for COVID-19 patients.Xianliang HouGuangyu WangWentao FanXiaoyan ChenChune MoYongsi WangWeiwei GongXuyan WenHui ChenDan HeLijun MoShaofeng JiangMinglin OuHaonan GuoHongbo LiuElsevierarticleCoronavirus disease 2019T-cell receptorSARS-CoV-2Adaptive immunityInfectious and parasitic diseasesRC109-216ENInternational Journal of Infectious Diseases, Vol 113, Iss , Pp 308-317 (2021) |
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DOAJ |
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DOAJ |
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EN |
| topic |
Coronavirus disease 2019 T-cell receptor SARS-CoV-2 Adaptive immunity Infectious and parasitic diseases RC109-216 |
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Coronavirus disease 2019 T-cell receptor SARS-CoV-2 Adaptive immunity Infectious and parasitic diseases RC109-216 Xianliang Hou Guangyu Wang Wentao Fan Xiaoyan Chen Chune Mo Yongsi Wang Weiwei Gong Xuyan Wen Hui Chen Dan He Lijun Mo Shaofeng Jiang Minglin Ou Haonan Guo Hongbo Liu T-cell receptor repertoires as potential diagnostic markers for patients with COVID-19 |
| description |
Objective: Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an ongoing global health emergency. T-cell receptors (TCRs) are crucial mediators of antiviral adaptive immunity. This study sought to comprehensively characterize the TCR repertoire changes in patients with COVID-19. Methods: A large sample size multi-center randomized controlled trial was implemented to study the features of the TCR repertoire and identify COVID-19 disease-related TCR sequences. Results: It was found that some T-cell receptor beta chain (TCRβ) features differed markedly between COVID-19 patients and healthy controls, including decreased repertoire diversity, longer complementarity-determining region 3 (CDR3) length, skewed utilization of the TCRβ variable gene/joining gene (TRBV/J), and a high degree of TCRβ sharing in COVID-19 patients. Moreover, this analysis showed that TCR repertoire diversity declines with aging, which may be a cause of the higher infection and mortality rates in elderly patients. Importantly, a set of TCRβ clones that can distinguish COVID-19 patients from healthy controls with high accuracy was identified. Notably, this diagnostic model demonstrates 100% specificity and 82.68% sensitivity at 0–3 days post diagnosis. Conclusions: This study lays the foundation for immunodiagnosis and the development of medicines and vaccines for COVID-19 patients. |
| format |
article |
| author |
Xianliang Hou Guangyu Wang Wentao Fan Xiaoyan Chen Chune Mo Yongsi Wang Weiwei Gong Xuyan Wen Hui Chen Dan He Lijun Mo Shaofeng Jiang Minglin Ou Haonan Guo Hongbo Liu |
| author_facet |
Xianliang Hou Guangyu Wang Wentao Fan Xiaoyan Chen Chune Mo Yongsi Wang Weiwei Gong Xuyan Wen Hui Chen Dan He Lijun Mo Shaofeng Jiang Minglin Ou Haonan Guo Hongbo Liu |
| author_sort |
Xianliang Hou |
| title |
T-cell receptor repertoires as potential diagnostic markers for patients with COVID-19 |
| title_short |
T-cell receptor repertoires as potential diagnostic markers for patients with COVID-19 |
| title_full |
T-cell receptor repertoires as potential diagnostic markers for patients with COVID-19 |
| title_fullStr |
T-cell receptor repertoires as potential diagnostic markers for patients with COVID-19 |
| title_full_unstemmed |
T-cell receptor repertoires as potential diagnostic markers for patients with COVID-19 |
| title_sort |
t-cell receptor repertoires as potential diagnostic markers for patients with covid-19 |
| publisher |
Elsevier |
| publishDate |
2021 |
| url |
https://doaj.org/article/e4863b545e454bbb99cb8e3dec682e83 |
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