Mice lacking the mitochondrial exonuclease MGME1 accumulate mtDNA deletions without developing progeria

It has been debated whether premature ageing in mitochondrial DNA mutator mice is driven by point mutations or deletions of mtDNA. Matic et al generate Mgme1 knockout mice and show here that these mice have tissue-specific replication stalling and accumulate deleted mtDNA, without developing progeri...

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Autores principales:	Stanka Matic, Min Jiang, Thomas J. Nicholls, Jay P. Uhler, Caren Dirksen-Schwanenland, Paola Loguercio Polosa, Marie-Lune Simard, Xinping Li, Ilian Atanassov, Oliver Rackham, Aleksandra Filipovska, James B. Stewart, Maria Falkenberg, Nils-Göran Larsson, Dusanka Milenkovic
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e4875b41d2804c3a99656ff7ae1c7aca
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spelling	oai:doaj.org-article:e4875b41d2804c3a99656ff7ae1c7aca2021-12-02T14:39:45ZMice lacking the mitochondrial exonuclease MGME1 accumulate mtDNA deletions without developing progeria10.1038/s41467-018-03552-x2041-1723https://doaj.org/article/e4875b41d2804c3a99656ff7ae1c7aca2018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03552-xhttps://doaj.org/toc/2041-1723It has been debated whether premature ageing in mitochondrial DNA mutator mice is driven by point mutations or deletions of mtDNA. Matic et al generate Mgme1 knockout mice and show here that these mice have tissue-specific replication stalling and accumulate deleted mtDNA, without developing progeria.Stanka MaticMin JiangThomas J. NichollsJay P. UhlerCaren Dirksen-SchwanenlandPaola Loguercio PolosaMarie-Lune SimardXinping LiIlian AtanassovOliver RackhamAleksandra FilipovskaJames B. StewartMaria FalkenbergNils-Göran LarssonDusanka MilenkovicNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Stanka Matic Min Jiang Thomas J. Nicholls Jay P. Uhler Caren Dirksen-Schwanenland Paola Loguercio Polosa Marie-Lune Simard Xinping Li Ilian Atanassov Oliver Rackham Aleksandra Filipovska James B. Stewart Maria Falkenberg Nils-Göran Larsson Dusanka Milenkovic Mice lacking the mitochondrial exonuclease MGME1 accumulate mtDNA deletions without developing progeria
description	It has been debated whether premature ageing in mitochondrial DNA mutator mice is driven by point mutations or deletions of mtDNA. Matic et al generate Mgme1 knockout mice and show here that these mice have tissue-specific replication stalling and accumulate deleted mtDNA, without developing progeria.
format	article
author	Stanka Matic Min Jiang Thomas J. Nicholls Jay P. Uhler Caren Dirksen-Schwanenland Paola Loguercio Polosa Marie-Lune Simard Xinping Li Ilian Atanassov Oliver Rackham Aleksandra Filipovska James B. Stewart Maria Falkenberg Nils-Göran Larsson Dusanka Milenkovic
author_facet	Stanka Matic Min Jiang Thomas J. Nicholls Jay P. Uhler Caren Dirksen-Schwanenland Paola Loguercio Polosa Marie-Lune Simard Xinping Li Ilian Atanassov Oliver Rackham Aleksandra Filipovska James B. Stewart Maria Falkenberg Nils-Göran Larsson Dusanka Milenkovic
author_sort	Stanka Matic
title	Mice lacking the mitochondrial exonuclease MGME1 accumulate mtDNA deletions without developing progeria
title_short	Mice lacking the mitochondrial exonuclease MGME1 accumulate mtDNA deletions without developing progeria
title_full	Mice lacking the mitochondrial exonuclease MGME1 accumulate mtDNA deletions without developing progeria
title_fullStr	Mice lacking the mitochondrial exonuclease MGME1 accumulate mtDNA deletions without developing progeria
title_full_unstemmed	Mice lacking the mitochondrial exonuclease MGME1 accumulate mtDNA deletions without developing progeria
title_sort	mice lacking the mitochondrial exonuclease mgme1 accumulate mtdna deletions without developing progeria
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/e4875b41d2804c3a99656ff7ae1c7aca
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Mice lacking the mitochondrial exonuclease MGME1 accumulate mtDNA deletions without developing progeria

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