Dissecting super-enhancer hierarchy based on chromatin interactions

Super-enhancers (SEs) are important regulatory elements for gene expression, but their intrinsic properties remain poorly understood. Here the authors analyse Hi-C and ChIP-seq data and find that a significant fraction of SEs are hierarchically organized, containing both hub and non-hub enhancers.

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Autores principales:	Jialiang Huang, Kailong Li, Wenqing Cai, Xin Liu, Yuannyu Zhang, Stuart H. Orkin, Jian Xu, Guo-Cheng Yuan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e48a2e2514b243a3815468a7ab792ce6
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spelling	oai:doaj.org-article:e48a2e2514b243a3815468a7ab792ce62021-12-02T16:49:18ZDissecting super-enhancer hierarchy based on chromatin interactions10.1038/s41467-018-03279-92041-1723https://doaj.org/article/e48a2e2514b243a3815468a7ab792ce62018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03279-9https://doaj.org/toc/2041-1723Super-enhancers (SEs) are important regulatory elements for gene expression, but their intrinsic properties remain poorly understood. Here the authors analyse Hi-C and ChIP-seq data and find that a significant fraction of SEs are hierarchically organized, containing both hub and non-hub enhancers.Jialiang HuangKailong LiWenqing CaiXin LiuYuannyu ZhangStuart H. OrkinJian XuGuo-Cheng YuanNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jialiang Huang Kailong Li Wenqing Cai Xin Liu Yuannyu Zhang Stuart H. Orkin Jian Xu Guo-Cheng Yuan Dissecting super-enhancer hierarchy based on chromatin interactions
description	Super-enhancers (SEs) are important regulatory elements for gene expression, but their intrinsic properties remain poorly understood. Here the authors analyse Hi-C and ChIP-seq data and find that a significant fraction of SEs are hierarchically organized, containing both hub and non-hub enhancers.
format	article
author	Jialiang Huang Kailong Li Wenqing Cai Xin Liu Yuannyu Zhang Stuart H. Orkin Jian Xu Guo-Cheng Yuan
author_facet	Jialiang Huang Kailong Li Wenqing Cai Xin Liu Yuannyu Zhang Stuart H. Orkin Jian Xu Guo-Cheng Yuan
author_sort	Jialiang Huang
title	Dissecting super-enhancer hierarchy based on chromatin interactions
title_short	Dissecting super-enhancer hierarchy based on chromatin interactions
title_full	Dissecting super-enhancer hierarchy based on chromatin interactions
title_fullStr	Dissecting super-enhancer hierarchy based on chromatin interactions
title_full_unstemmed	Dissecting super-enhancer hierarchy based on chromatin interactions
title_sort	dissecting super-enhancer hierarchy based on chromatin interactions
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/e48a2e2514b243a3815468a7ab792ce6
work_keys_str_mv	AT jialianghuang dissectingsuperenhancerhierarchybasedonchromatininteractions AT kailongli dissectingsuperenhancerhierarchybasedonchromatininteractions AT wenqingcai dissectingsuperenhancerhierarchybasedonchromatininteractions AT xinliu dissectingsuperenhancerhierarchybasedonchromatininteractions AT yuannyuzhang dissectingsuperenhancerhierarchybasedonchromatininteractions AT stuarthorkin dissectingsuperenhancerhierarchybasedonchromatininteractions AT jianxu dissectingsuperenhancerhierarchybasedonchromatininteractions AT guochengyuan dissectingsuperenhancerhierarchybasedonchromatininteractions
_version_	1718383368691777536

Dissecting super-enhancer hierarchy based on chromatin interactions

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