Pharmacologic modulation of 5-fluorouracil by folinic acid and high-dose pyridoxine for treatment of patients with digestive tract carcinomas

Abstract Supplementation of cancer cells exposed to 5-fluorouracil (FUra) and folinic acid (FA) with high concentration pyridoxal 5′-phosphate, the cofactor of vitamin B6, potentiates the cytotoxicity of FUra in a synergistic interaction mode. We report a pilot study in 13 patients with previously u...

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Auteurs principaux: David Machover, Wathek Almohamad, Vincent Castagné, Christophe Desterke, Léa Gomez, Yann Gaston-Mathé, Claude Boucheix, Emma Goldschmidt
Format: article
Langue:EN
Publié: Nature Portfolio 2021
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Accès en ligne:https://doaj.org/article/e48a6dffbe93495e979f8eb33857f074
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