Apolipoprotein A5-1131T>C Polymorphism Associated with Lipid Profile in Babol Population

BACKGROUND AND OBJECTIVE: Apolipoprotein A5 gene plays an important role in plasma lipid regulation. Protein deficiency of apolipoprotein A5 gene causes an increase in plasma triglyceride. The aim of this study was to assay the effect of apolipoprotein A5-1131T>C polymorphism associated with lipi...

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Autores principales:	SH Shojaee, S Halalkhor, SF Jalali, K Hajian, R Ataie, H Nadimi, MR Zahedpasha
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2010
Materias:	apolipoprotein a5 polymorphism triglyceride Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/e48c72a3e346469c94e81bf994eaec6a
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spelling	oai:doaj.org-article:e48c72a3e346469c94e81bf994eaec6a2021-11-10T09:00:14ZApolipoprotein A5-1131T>C Polymorphism Associated with Lipid Profile in Babol Population1561-41072251-7170https://doaj.org/article/e48c72a3e346469c94e81bf994eaec6a2010-04-01T00:00:00Zhttp://jbums.org/article-1-3409-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: Apolipoprotein A5 gene plays an important role in plasma lipid regulation. Protein deficiency of apolipoprotein A5 gene causes an increase in plasma triglyceride. The aim of this study was to assay the effect of apolipoprotein A5-1131T>C polymorphism associated with lipid profile in Babol population.METHODS: This case-control study was performed on 199 people in Babol. They were divided into two groups under supervision of the specialist and with regard to their medical history and files: low triglyceride group (99 persons with triglyceride< 103 mg/dl) and high triglyceride group (100 persons with triglyceride> 150 mg/dl) and their biochemistry and anthropometric parameter were measured. The apolipoprotein A5 gene was amplified by PCR method and polymorphism was revealed by the use of MseI enzyme with RFLP method and then compared.FINDINDS: Allele C frequency in people with high triglyceride was 0.21 and in people with low triglyceride was 0.11 that these differences were statistically significant (p=0.02). Also, significant association was found between serum triglyceride (p=0.016) and C allele in low and high triglyceride groups. Being carrier allele C versus TT genotype increased the chance of high triglyceride OR=1.97 times (95% CI=1.35-3.68).CONCLUSION: Our study confirms the association of the APOA5 -1131T>C polymorphism with triglyceride levels in humans. Therefore, genetically evaluation of subjects with high triglyceride recommends to determine allele and diagnosis of cardiovascular patient.SH ShojaeeS HalalkhorSF JalaliK HajianR Ataie,H Nadimi,MR ZahedpashaBabol University of Medical Sciencesarticleapolipoprotein a5polymorphismtriglycerideMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 12, Iss 1, Pp 29-35 (2010)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	apolipoprotein a5 polymorphism triglyceride Medicine R Medicine (General) R5-920
spellingShingle	apolipoprotein a5 polymorphism triglyceride Medicine R Medicine (General) R5-920 SH Shojaee S Halalkhor SF Jalali K Hajian R Ataie, H Nadimi, MR Zahedpasha Apolipoprotein A5-1131T>C Polymorphism Associated with Lipid Profile in Babol Population
description	BACKGROUND AND OBJECTIVE: Apolipoprotein A5 gene plays an important role in plasma lipid regulation. Protein deficiency of apolipoprotein A5 gene causes an increase in plasma triglyceride. The aim of this study was to assay the effect of apolipoprotein A5-1131T>C polymorphism associated with lipid profile in Babol population.METHODS: This case-control study was performed on 199 people in Babol. They were divided into two groups under supervision of the specialist and with regard to their medical history and files: low triglyceride group (99 persons with triglyceride< 103 mg/dl) and high triglyceride group (100 persons with triglyceride> 150 mg/dl) and their biochemistry and anthropometric parameter were measured. The apolipoprotein A5 gene was amplified by PCR method and polymorphism was revealed by the use of MseI enzyme with RFLP method and then compared.FINDINDS: Allele C frequency in people with high triglyceride was 0.21 and in people with low triglyceride was 0.11 that these differences were statistically significant (p=0.02). Also, significant association was found between serum triglyceride (p=0.016) and C allele in low and high triglyceride groups. Being carrier allele C versus TT genotype increased the chance of high triglyceride OR=1.97 times (95% CI=1.35-3.68).CONCLUSION: Our study confirms the association of the APOA5 -1131T>C polymorphism with triglyceride levels in humans. Therefore, genetically evaluation of subjects with high triglyceride recommends to determine allele and diagnosis of cardiovascular patient.
format	article
author	SH Shojaee S Halalkhor SF Jalali K Hajian R Ataie, H Nadimi, MR Zahedpasha
author_facet	SH Shojaee S Halalkhor SF Jalali K Hajian R Ataie, H Nadimi, MR Zahedpasha
author_sort	SH Shojaee
title	Apolipoprotein A5-1131T>C Polymorphism Associated with Lipid Profile in Babol Population
title_short	Apolipoprotein A5-1131T>C Polymorphism Associated with Lipid Profile in Babol Population
title_full	Apolipoprotein A5-1131T>C Polymorphism Associated with Lipid Profile in Babol Population
title_fullStr	Apolipoprotein A5-1131T>C Polymorphism Associated with Lipid Profile in Babol Population
title_full_unstemmed	Apolipoprotein A5-1131T>C Polymorphism Associated with Lipid Profile in Babol Population
title_sort	apolipoprotein a5-1131t>c polymorphism associated with lipid profile in babol population
publisher	Babol University of Medical Sciences
publishDate	2010
url	https://doaj.org/article/e48c72a3e346469c94e81bf994eaec6a
work_keys_str_mv	AT shshojaee apolipoproteina51131tcpolymorphismassociatedwithlipidprofileinbabolpopulation AT shalalkhor apolipoproteina51131tcpolymorphismassociatedwithlipidprofileinbabolpopulation AT sfjalali apolipoproteina51131tcpolymorphismassociatedwithlipidprofileinbabolpopulation AT khajian apolipoproteina51131tcpolymorphismassociatedwithlipidprofileinbabolpopulation AT rataie apolipoproteina51131tcpolymorphismassociatedwithlipidprofileinbabolpopulation AT hnadimi apolipoproteina51131tcpolymorphismassociatedwithlipidprofileinbabolpopulation AT mrzahedpasha apolipoproteina51131tcpolymorphismassociatedwithlipidprofileinbabolpopulation
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Apolipoprotein A5-1131T>C Polymorphism Associated with Lipid Profile in Babol Population

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